Cuproptosis associated cytoskeletal destruction contributes to podocyte injury in chronic kidney disease
Han Li,
Yingjie Fu,
Yue Xu
et al.
Abstract:The podocyte cytoskeleton determines the stability of podocyte structure and function, and their imbalance plays a pathogenic role in podocyte diseases. However, the underlying mechanism of podocyte cytoskeleton damage is not fully understood. Here, we investigate the specific role of cuproptosis in inducing podocyte cytoskeleton injury. In vitro and in vivo studies, exposure to high levels of copper and adriamycin (ADR) caused significant increases in copper concentration in intracellular and renal tissue. Mo… Show more
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