Cupping regulates local immunomodulation to activate neural-endocrine-immune worknet

Guo, Yang; Chen, Bin; Wang, Dongqiang; Li, Mingyue; Lim, Calista Hui-min; Guo, Yi; Chen, Zelin

doi:10.1016/j.ctcp.2017.04.005

Cited by 24 publications

(15 citation statements)

References 9 publications

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“…(2017) proposed that the microenvironment is changed when stimulating the surface of the skin, and physical signals transform into biological signals, which also interact with each other in the body. These signaling cascades activate the neuroendocrine-immune system, which produces the therapeutic effect 95 . More immunological studies are needed to measure and validate the early assumption.…”

Section: Resultsmentioning

confidence: 99%

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The medical perspective of cupping therapy: Effects and mechanisms of action

Al-Bedah

Elsubai

Qureshi

et al. 2019

Journal of Traditional and Complementary Medicine

150

144

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Cupping Therapy (CT) is an ancient method and currently used in the treatment of a broad range of medical conditions. Nonetheless the mechanism of action of (CT) is not fully understood. This review aimed to identify possible mechanisms of action of (CT) from modern medicine perspective and offer possible explanations of its effects. English literature in PubMed, Cochrane Library and Google Scholar was searched using key words. Only 223 articles identified, 149 records screened, and 74 articles excluded for irrelevancy. Only 75 full-text articles were assessed for eligibility, included studies in this review were 64. Six theories have been suggested to explain the effects produced by cupping therapy. Pain reduction and changes in biomechanical properties of the skin could be explained by “Pain-Gate Theory”, “Diffuse Noxious Inhibitory Controls” and “Reflex zone theory”. Muscle relaxation, changes in local tissue structures and increase in blood circulation might be explained by “Nitric Oxide theory”. Immunological effects and hormonal adjustments might be attributed to “Activation of immune system theory”. Releasing of toxins and removal of wastes and heavy metals might be explained by “Blood Detoxification Theory”. These theories may overlap or work interchangeably to produce various therapeutic effects in specific ailments and diseases. Apparently, no single theory exists to explain the whole effects of cupping. Further researches are needed to support or refute the aforesaid theories, and also develop innovative conceptualizations of (CT) in future.

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Section: Resultsmentioning

confidence: 99%

“…These signaling cascades activate the neuroendocrine-immune system, which produces the therapeutic effect. 95 More immunological studies are needed to measure and validate the early assumption.…”

Section: Resultsmentioning

confidence: 99%

The medical perspective of cupping therapy: Effects and mechanisms of action

Al-Bedah

Elsubai

Qureshi

et al. 2019

Journal of Traditional and Complementary Medicine

150

144

View full text Add to dashboard Cite

show abstract

“…Wet cupping eliminates oxidant material and reduces oxidative stress [28]. Guo et al [29] suggest a similar mechanism for both wet cupping and acupuncture. Physical signals in wet cupping and acupuncture convert to biological signals and these signals activate the neuroendocrine-immune system.…”

Section: Discussionmentioning

confidence: 99%

Effectiveness of Wet Cupping on Patients with Facial Acne Vulgaris: A 12-Week, Randomized, Single-Blind, Intervention-Sham-Controlled Trial

et al. 2021

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Introduction: Acne vulgaris is a widespread skin disorder. The aim of this study was to assess the effectiveness of wet cupping in the treatment of moderate to severe facial acne vulgaris. Methods: Between August 2018 and January 2020, eligible patients with moderate to severe facial acne were recruited in this single-blind, intervention-sham-controlled clinical trial in Iran. The intervention group received wet cupping twice and likewise the control group received sham cupping. Also, both groups received 500 mg azithromycin 3 times/week for 12 weeks. Acne grades were assessed 6 weeks and 12 weeks after beginning of the treatment by the dermatologist uninformed of group allocation and participant self-assessment. Quality of life was assessed with valid questionnaire before and after the treatment. Result: Totally, 103 patients completed the trial. The patients in the intervention group had better improvement and grade of acne compared to the control group at the end of the trial. Patients showed a shorter time to removing facial lesions in the intervention group in contrast with the control group (p < 0.001). Quality of life significantly increased in the intervention group compared with the control group (p = 0.004). Conclusion: Wet cupping plus antibiotic therapy seems to be more effective than antibiotic therapy per se in patients with facial acne vulgaris.

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“…As a method of external stimulation, cupping causes changes in the microenvironment by local stimulation, leading to capillary rupture, release of large amounts of signaling molecules, and subsequent activation of the neural-endocrine-immune network to create an overall regulatory function. 18 Although the mechanism by which acupuncture improves pregnancy rates remains unclear, it is feasible that acu-puncture increases ovulation frequency and/or improves oocyte quality. [19][20][21] Acupuncture might reduce blood flow impedance of uterine arteries, 22,23 reduce contraction frequency of the uterine junctional zone, and consolidate embryo implantation.…”

Section: Discussionmentioning

confidence: 99%

Positive Effect of Acupuncture and Cupping in Infertility Treatment

Wang

Yang

Song

et al. 2018

Medical Acupuncture

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Infertility is clinically defined as the failure to conceive after 12 months of unprotected sexual intercourse. Organic disorders and lifestyle factors are highly associated with infertility. Generally, acupuncture and its related methods can be applied for treating infertility, according to the theory of Traditional Chinese Medicine. Successful cases of acupuncture-treated infertility without concomitant use of any medication are rare. This article presents a case of an infertile woman having a favorable response to acupuncture treatment. A 39-year-old Mexican woman presented with infertility following right-side fallopian-tube obstruction. She had no significant physical feelings of discomfort apart from work-related stress. Her syndrome was first diagnosed as Deficiency of Spleen and Kidney Qi, accompanied by obstruction of channels due to accumulation of Dampness. Acupuncture, accompanied by cupping therapy, was primarily practiced for this patient. After 28 treatment sessions, she was finally able to conceive. Acupuncture could help treat infertility. Further large-scale, randomized clinical trials are needed to verify the efficacy of acupuncture for treating female infertility.

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Cupping regulates local immunomodulation to activate neural-endocrine-immune worknet

Cited by 24 publications

References 9 publications

The medical perspective of cupping therapy: Effects and mechanisms of action

The medical perspective of cupping therapy: Effects and mechanisms of action

Effectiveness of Wet Cupping on Patients with Facial Acne Vulgaris: A 12-Week, Randomized, Single-Blind, Intervention-Sham-Controlled Trial

Positive Effect of Acupuncture and Cupping in Infertility Treatment

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