CuO-NPs/TFA: a New Catalytic System to Synthesize a Novel Series of Pyrazole Imines with High Antioxidant Properties

Elnagdy, Hanan Mohamed Fathy; Gogoi, Nishi Gandha; Handique, Jyotirekha G.; Sarma, Diganta

doi:10.1007/s12668-021-00888-5

Cited by 2 publications

(1 citation statement)

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“…[20,21] Although many metals such as zinc (Zn), silver (Ag), nickel (Ni) and gold (Au) have been reported as coupling catalysts, [22] Cu (I) is commonly used for this aim. [23][24][25][26] The coppercatalysed alkyne-azide cycloaddition (CuAAC) reaction represents the flagship transformation of "Click Chemistry" that has considerable applications in organic synthesis, coordination chemistry and material science. [27] With over 2,000 documented reports in about a decade, the CuAAC reaction is notable and undoubtedly has been a breakthrough in organic synthesis and Cu (I) catalysis.…”

Section: Introductionmentioning

confidence: 99%

New Cu (I) complexes as catalyst for “click” reaction: An experimental and computational study

Gholivand

Faraghi

Malekshah

et al. 2023

Applied Organom Chemis

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In this work, two novel well‐defined Cu (I) complexes of a Schiff base ligand are described. For this purpose, N, N′‐bis (trans‐cinnamaldehyde) ethylenediimine [C20H20N2] (L) and Cu (I) complex of the type [CuC20H20N2)PPh3Cl] (C1) and [Cu(C20H20N2)PPh3Br] (C2) were synthesised. IR, NMR, XRD and TGA analyses were used to characterise these compounds and single‐crystal X‐ray crystallography confirmed the structure of the compounds. The catalytic activity of the synthesised complexes was studied in azide‐alkyne click reaction (AAC) and the best reaction condition was 15 mol% catalyst, 30 min and 45°C in water, which can be considered moderate catalytic activity for the complexes. Material Studio 2017 software was used to obtain the geometry, energy, HOMO and LUMO of all structures by the quantum calculations (module DMol3 and LDA/PWC). The computational results showed catalyst C2 has more reactivity than catalyst C1, and the C1‐catalysed products form faster than the C2‐catalysed products exceptions 4a and 4b. Product 4b (resulting catalyst C2) is formed faster than product (4a).

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Section: Introductionmentioning

confidence: 99%

New Cu (I) complexes as catalyst for “click” reaction: An experimental and computational study

Gholivand

Faraghi

Malekshah

et al. 2023

Applied Organom Chemis

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A Review of the Recent Development in the Synthesis and Biological Evaluations of Pyrazole Derivatives

2022

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Pyrazoles are five-membered heterocyclic compounds that contain nitrogen. They are an important class of compounds for drug development; thus, they have attracted much attention. In the meantime, pyrazole derivatives have been synthesized as target structures and have demonstrated numerous biological activities such as antituberculosis, antimicrobial, antifungal, and anti-inflammatory. This review summarizes the results of published research on pyrazole derivatives synthesis and biological activities. The published research works on pyrazole derivatives synthesis and biological activities between January 2018 and December 2021 were retrieved from the Scopus database and reviewed accordingly.

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CuO-NPs/TFA: a New Catalytic System to Synthesize a Novel Series of Pyrazole Imines with High Antioxidant Properties

Cited by 2 publications

References 50 publications

New Cu (I) complexes as catalyst for “click” reaction: An experimental and computational study

New Cu (I) complexes as catalyst for “click” reaction: An experimental and computational study

A Review of the Recent Development in the Synthesis and Biological Evaluations of Pyrazole Derivatives

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