CuNiFe a Magnetic Nano‐Catalyst: an Efficient Catalyst for the Selective Synthesis of Benzoxazoles

Abstract

An efficient protocol for the synthesis of benzoxazoles from o‐nitrophenols and benzyl alcohols using CuNiFe as a magnetic nano‐catalyst via hydrogenation transfer has been described. The CuNiFe magnetic nano‐catalyst was prepared by an operationally simple method, without the use of any toxic reagents. The prepared catalyst was characterized by XRD, FEG‐SEM, EDAX, TEM, and FT‐IR techniques. No additional additives such as oxidants and reductants were required for this reaction. CuNiFe magnetic nano‐catalyst showed good air stability and could be recycled up to six times without any significant loss in its catalytic activity.

Nanocatalyzed Synthesis of Benzoxazoles

“…Due to the employment of a toxic toluene solvent in the benzoxazole synthesis, the approach appears to be less notable. [63] In 2018, K. Bahrami's group proposed that mesoporous titania-alumina mixed oxide (MTAMO, Table 2, entry 8) be used as a highly efficient nanocatalyst for the synthesis of 2substituted benzoxazoles (72) through one-pot condensation reaction of ortho aminophenol (19) and various aromatic aldehydes (71) in presences of MTAMO catalyst in ethanol at 50 °C (Scheme 23). In this method using 30 % H 2 O 2 as a green oxidant and sodium dodecyl sulfate as a structure-guiding agent by the sol-gel method.…”

“…The CuNiFe magnetic nano‐catalyst demonstrated good air stability and could be recycled up to 6 times without losing catalytic activity. Due to the employment of a toxic toluene solvent in the benzoxazole synthesis, the approach appears to be less notable [63] …”