Cuneatoside, a new megastigmane diglycoside from <i>Erythroxylum cuneatum</i> Blume

Kanchanapoom, Tripetch; Sirikatitham, Anusak; Otsuka, Hideaki; Ruchirawat, Somsak

doi:10.1080/10286020500246519

Cited by 13 publications

(11 citation statements)

References 11 publications

(14 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…alkaloid in E. cuneatum leaves extract. As reported by El-Imam [18] and Kanchanapoom [20], tropane alkaloids including (AE)-3α,6ß-dibenzoyloxytropane act as principal alkaloid in E. cuneatum. Besides, benzoyland tigloyl-esters and nicotine were also found in E. cuneatum leaves extract.…”

Section: Discussionmentioning

confidence: 57%

“…These major alkaloids plays an important role in the properties of E. cuneatum extract. E. cuneatum is also known to have compounds like inamoside 60 -O-L-aarabinofuranoside, (þ)-Catechin, quercetin 3-O-alpha-Lrhamnoside, apocynol B, (6S,9R)-roseoside, vomifoliol 9-Oalpha-L-arabinofuranosyl (1-->6)-beta-D-glucopyranoside inamoside, and citroside A [20]. These alkaloids were all reported without specifically knowing which one exerts the antioxidant & anti-inflammatory properties of E. cuneatum.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Antioxidant and anti-inflammatory properties of Erythroxylum cuneatum alkaloid leaf extract

Chiroma

Hashim

et al. 2020

Heliyon

View full text Add to dashboard Cite

Erythroxylum cuneatum (E. cuneatum) which belongs to Erythroxylaceae family is a tropical flowering plant from the genus of Erythroxylum. It is used in Malaysia and Thailand's traditional medicines, yet there is limited scientific reports on its medicinal value. This study aimed at exploring the antioxidative and anti-inflammatory properties of E. cuneatum alkaloid leaf extract. The alkaloid extract was obtained through Soxhlet heat extraction method, while the antioxidantive properties were assessed via 2,2-diphenyl-1-picrylhydrazyl (DPPH) free radical scavenging, ferric reducing antioxidant power (FRAP) and xanthine oxidase inhibition (XOI) assays. Further, anti-inflammatory property of the extract was evaluated on rat's model of carrageenan induced paw model of edema via physical measurements and histology. The extract exhibited antioxidant activity with an EC 50 value of 1482 μg/ml in the DPPH radical scavenging assay, an EC 1 value of 2191 μg/ml in the FRAP assay and 10.15 AE 6.20% in the XOI assay. Rats pretreated with the extract have shown dose dependent decrease in paw edema when compared to non-treated group of rats. The highest dose (50 mg/kg) of extract exhibited similar effects to aspirin in terms of reducing paw thickness, leucocytes infiltration and disruption of collagen. In conclusion, the E. cuneatum alkaloid leaf extract possesses both antioxidative and anti-inflammatory properties suggesting its potentials for future development of antioxidant and anti-inflammatory drugs.

show abstract

Section: Discussionmentioning

confidence: 57%

Section: Discussionmentioning

confidence: 99%

Antioxidant and anti-inflammatory properties of Erythroxylum cuneatum alkaloid leaf extract

Chiroma

Hashim

et al. 2020

Heliyon

View full text Add to dashboard Cite

show abstract

“…25 A study of the components of Youngia japonica 26 led to the isolation of the glucoside 36. An inamoside derivative, named cuneatoside, has been found in an extract from the leaves and branches of Erythroxylum cuneatum, 27 whilst vignoside 37, a glucoside that inhibits the growth of human stomach cancer, has been obtained from Vigna angularis (adzuki bean). 28 Several glycosides of blumenol C, 13-hydroxyblumenol C and 13-nor-5-carboxy-blumenol C accumulate when roots of Ornithogalum umbellatum are colonised by an arbuscular mycorrhizal fungus.…”

Section: Monocyclofarnesanementioning

confidence: 99%

Natural sesquiterpenoids

Fraga

2010

Nat. Prod. Rep.

View full text Add to dashboard Cite

show abstract

“…Norisoprenoid compounds (megastigmanes, 181–187 ) have been characterized in E. cuneatum [ 74 ] and E. cambodianum [ 72 ] by Kanchanapoom et al (Fig. 8 ; Table 8 ).…”

Section: Chemical Compositionmentioning

confidence: 99%

Advances in chemistry and bioactivity of the genus Erythroxylum

Tian

Wang

et al. 2022

Nat. Prod. Bioprospect.

View full text Add to dashboard Cite

Erythroxylum P. Browne is the largest and most representative genus of Erythroxylaceae family. It contains approximately 230 species that are mainly distributed in tropical and subtropical regions. Some species in this genus, such as E.monogynum and E.coca, have been used as folk medicines in India or South America for a long history. It is well known that Erythroxylum plants are rich in tropane alkaloids, and the representative member cocaine shows remarkable activity in human central nervous system. However, many other types of active compounds have also been found in Erythroxylum along with the broadening and deepening of phytochemical research. To date, a total of 383 compounds from Erythroxylum have been reported, among which only 186 tropane alkaloids have been reviewed in 2010. In this review, we summarized all remained 197 compounds characterized from 53 Erythroxylum species from 1960 to 2021, which include diterpenes, triterpenes, alkaloids, flavonoids, and other derivates, providing a comprehensive overview of phytoconstituents profile of Erythroxylum plants. In addition, the biological activities of representative phytochemicals and crude extracts were also highlighted. Graphical Abstract

show abstract

Cuneatoside, a new megastigmane diglycoside from Erythroxylum cuneatum Blume

Cited by 13 publications

References 11 publications

Antioxidant and anti-inflammatory properties of Erythroxylum cuneatum alkaloid leaf extract

Antioxidant and anti-inflammatory properties of Erythroxylum cuneatum alkaloid leaf extract

Natural sesquiterpenoids

Advances in chemistry and bioactivity of the genus Erythroxylum

Contact Info

Product

Resources

About