Cumulative Prognostic Scores Based on Plasma Fibrinogen and Serum Albumin Levels in Esophageal Cancer Patients Treated with Transthoracic Esophagectomy: Comparison with the Glasgow Prognostic Score

Matsuda, Satoru; Takeuchi, Hiroya; Kawakubo, Hirofumi; Fukuda, Kazumasa; Nakamura, Rieko; Takahashi, Tsunehiro; Wada, Norihito; Saikawa, Yoshirou; Omori, Tai; Kitagawa, Yuko

doi:10.1245/s10434-014-3857-5

Cited by 78 publications

(78 citation statements)

References 34 publications

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“…Although their analysis mainly included patients with adenocarcinomas, and neoadjuvant chemotherapy comprised an epirubicin-based regimen, the study suggests that malnutrition was associated with the lack of response to chemotherapy. Two studies have also reported that low serum Alb is significantly associated with poor prognosis in patients who have undergone esophagectomy for esophageal SCC [23,24]. Although the histological backgrounds were different in these studies, their results are consistent with ours.…”

Section: Discussionsupporting

confidence: 89%

Prognostic Factors in Patients Receiving Neoadjuvant 5-Fluorouracil plus Cisplatin for Advanced Esophageal Cancer (JCOG9907)

Yokota

Ando

Igaki³

et al. 2015

Oncology

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Objective: Neoadjuvant chemotherapy with 5-fluorouracil plus cisplatin and subsequent esophagectomy with two- to three-field lymphadenectomy is a standard treatment for patients with clinical stage II/III squamous cell carcinoma (SCC) of the esophagus. This study investigates the prognostic factors for patients who received neoadjuvant chemotherapy. Methods: Of 164 patients assigned to receive neoadjuvant chemotherapy in the JCOG9907 trial, multivariate analyses were performed for 159 and 149 patients to evaluate the preoperative and the combined preoperative and postoperative prognostic factors, respectively. Results: The multivariate analyses using preoperative factors showed that clinical stage T3 [vs. cT1-2; hazard ratio (HR) 3.60, p = 0.0007] and serum albumin (Alb) <4.0 g/dl (vs. ≥4.0 g/dl; HR 2.29, p = 0.0005) were associated with a poor prognosis. Four independent prognostic factors were identified by multivariate analysis of both preoperative and postoperative factors: pathological curability B (pB; R0 with stage IV or pD < pN) or pC [microscopic or macroscopic residual tumor (R1/R2)] [vs. pA (R0); HR 1.93, p = 0.015], pathological stage N1 (vs. pN0; HR 3.86, p = 0.0012), cT3 (vs. cT1-2; HR 2.80, p = 0.0073), and serum Alb <4.0 g/dl (vs. ≥4.0 g/dl; HR 2.03, p = 0.0069). Conclusions: Preoperative cT stage, Alb, and postoperative pathological findings are independent prognostic factors for patients undergoing neoadjuvant chemotherapy for advanced thoracic esophageal SCC. This analysis may aid in stratification according to individual patient risk.

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Section: Discussionsupporting

confidence: 89%

Prognostic Factors in Patients Receiving Neoadjuvant 5-Fluorouracil plus Cisplatin for Advanced Esophageal Cancer (JCOG9907)

Yokota

Ando

Igaki³

et al. 2015

Oncology

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“…FA score was observed to have an association with tumor invasion depth, lymph node metastasis, and postoperative survival in esophageal cancer patients 15. In our cohort, the FA score showed a statistical relation with smoking status, differential grade, T stage, and TNM stage.…”

Section: Discussionsupporting

confidence: 52%

Plasma fibrinogen and serum albumin levels (FA score) act as a promising prognostic indicator in non-small cell lung cancer

Chen

Cheng

Nesa

et al. 2017

OTT

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BackgroundEvidence implies that preoperative plasma fibrinogen and serum albumin are associated with cancer prognosis. We aimed to explore the prognostic values of the score based on plasma fibrinogen and serum albumin levels (FA score) in non-small cell lung cancer (NSCLC), and to compare that with prognostic nutritional index (PNI).Patients and methodsIn all, 182 patients pathologically diagnosed with NSCLC were included in this study. Kaplan–Meier survival analysis and multivariate analysis were used in the prognostic analyses.ResultsHigh FA score was related to smoking (P=0.005), poor differential grade (P=0.002), and advanced T stage (P<0.001) and tumor, node, and metastases stage (P=0.011). Low PNI showed association with advanced T stage (P=0.030). Kaplan–Meier survival analysis indicated that high FA score and low PNI were associated with poor progression-free survival (PFS; for the FA score, P<0.001; for PNI, P=0.001) and overall survival (OS; for the FA score, P<0.001; for PNI, P=0.013), respectively. Multivariate analysis revealed that FA score was an independent predictor for PFS (P=0.003) and OS (P=0.001) in NSCLC patients.ConclusionThe FA score could act as a more promising prognostic predictor than PNI in NSCLC patients who underwent pneumonectomy.

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“…Previous studies have demonstrated that decreased albumin levels could not be commonly observed in early or locally advanced esophageal caner patients, leaving it insufficient for risk classification [13–15]. Recently, two studies observed better nutrition status in operable esophageal cancer patients than in those with metastatic disease [11, 15].…”

Section: Discussionmentioning

confidence: 99%

“…Recently, two studies observed better nutrition status in operable esophageal cancer patients than in those with metastatic disease [11, 15]. Matsuda et al defined the serum albumin cut-off value as 38.0 g/L according to the lower quartile range, and showed that the prognostic indicator based on preoperative plasma fibrinogen and serum albumin levels (FA score) was remarkably predictive of postoperative survival in esophageal cancer patients [15]. Meanwhile, Zhang and his colleagues established the preoperative albumin-globulin score (AGS) based on a cutoff value of 45.6 g/L for albumin, and identified its independent prognostic significance for OS in resectable ESCC [11].…”

Section: Discussionmentioning

confidence: 99%

“…Previous studies have indicated that albumin levels were not always decreased in operable esophageal cancer patients, making nutritional deficiency insufficient for risk stratification [13–15]. In addition, the preoperative albumin-globulin score (AGS) determined with a cutoff value of 45.6 g/L for albumin has been identified as an independent predictor for OS in resectable ESCC [11].…”

Section: Introductionmentioning

confidence: 99%

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The preoperative sensitive-modified Glasgow prognostic score is superior to the modified Glasgow prognostic score in predicting long-term survival for esophageal squamous cell carcinoma

et al. 2016

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The present study was designed to investigate the prognostic significance of the preoperative sensitive-modified Glasgow prognostic score (S-mGPS) and its superiority in esophageal squamous cell carcinoma (ESCC). Clinicopathologic characteristics, preoperative albumin and C-reactive protein (CRP) levels were retrospectively collected in 442 patients who underwent transthoracic esophagectomy. The S-mGPS was calculated before surgery based on optimal cutoff values of 45.6 g/L for albumin and 10.0 mg/L for CRP. 360, 74 and 8 cases were assigned an mGPS of 0, 1 and 2, respectively. In contrast, the S-mGPS was 0 in 114, 1 in 258 and 2 in 70 patients. Of the 360 patients with an mGPS of 0, 246 migrated to the S-mGPS-1 group. Both mGPS and S-mGPS were significantly correlated with tumor length, depth of invasion, pathological tumor-node-metastasis (pTNM) stage and adjuvant treatment. In addition, they were significantly associated with disease free survival (DFS) and overall survival (OS) in univariate analysis. Furthermore, multivariate Cox regression analysis identified S-mGPS as an independent prognostic indicator for both DFS [hazard ratio (HR), 1.577; 95% confidence interval (CI), 1.149-2.163; P = 0.005] and OS (HR, 1.762; 95% CI, 1.250-2.484; P = 0.001), but not mGPS (HR, 0.957; 95% CI, 0.692-1.323; P = 0.790 for DFS and HR, 1.089; 95% CI, 0.781-1.517; P = 0.615 for OS, respectively). Moreover, subgroup analysis revealed that the prognostic impact of the S-mGPS was especially striking in pTNM stage II patients. The preoperative S-mGPS is superior to the mGPS as a prognostic predictor in patients with resectable ESCC.

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Cumulative Prognostic Scores Based on Plasma Fibrinogen and Serum Albumin Levels in Esophageal Cancer Patients Treated with Transthoracic Esophagectomy: Comparison with the Glasgow Prognostic Score

Abstract: Preoperative FA score was significantly associated with postoperative survival in esophageal cancer patients, and the prognostic value is currently being validated in a prospective multicenter cohort study.

Cited by 78 publications

References 34 publications

Prognostic Factors in Patients Receiving Neoadjuvant 5-Fluorouracil plus Cisplatin for Advanced Esophageal Cancer (JCOG9907)

Prognostic Factors in Patients Receiving Neoadjuvant 5-Fluorouracil plus Cisplatin for Advanced Esophageal Cancer (JCOG9907)

Plasma fibrinogen and serum albumin levels (FA score) act as a promising prognostic indicator in non-small cell lung cancer

The preoperative sensitive-modified Glasgow prognostic score is superior to the modified Glasgow prognostic score in predicting long-term survival for esophageal squamous cell carcinoma

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