Cumulative irritation in older and younger human skin - a comparison

Schwindt, D A; Wilhelm, Klaus‐Peter; Miller, Dana L.; Hi, Maibach

doi:10.1016/s0923-1811(98)84219-9

Cited by 3 publications

(3 citation statements)

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“…3. By contrast, aged skin is less susceptible to irritating stimuli than younger skin, which is consistent with the lower incidence of irritant dermatitis in the elderly [244][245][246]. It was revealed that the recovery processes after acute barrier perturbation are delayed in the aged vs. the young population [243].…”

Section: Assessment Of Skin Barrier Functionmentioning

confidence: 60%

Anti‐Aging Data and Support Claims – Consensus Statement

Elsner¹,

Fluhr²,

Gehring³

et al. 2011

J Deutsche Derma Gesell

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Section: Assessment Of Skin Barrier Functionmentioning

confidence: 60%

Anti‐Aging Data and Support Claims – Consensus Statement

Elsner¹,

Fluhr²,

Gehring³

et al. 2011

J Deutsche Derma Gesell

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“…Since the Young's modulus of the flexible circuit (E circuit ) is much higher than the Young's modulus of the elastomeric membrane (E elastomer ), we estimated the effective Young's modulus of the device as [56]. When we assume skin conditions as E skin = 130 kPa, h rough = 90 µm, and λ rough = 180 µm [57,58] and estimate E circuit ≈ E PI = 2.5 GPa, E elastomer = 10 kPa, and h circuit = 25 µm, the Equation ( 2) provides a relationship between desired work of adhesion of the elastomeric membrane (γ elastomer ) and the thickness of the elastomeric membrane (h elstomer ) that allows the device to form conformal contact with the skin as shown In Figure 2a. In the previous report, the work of the adhesion of the elastomeric membrane was measured as approx.…”

Section: Resultsmentioning

confidence: 99%

Experimental Study: Deep Learning-Based Fall Monitoring among Older Adults with Skin-Wearable Electronics

Lee

Pokharel

Muslim

et al. 2023

Sensors

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Older adults are more vulnerable to falling due to normal changes due to aging, and their falls are a serious medical risk with high healthcare and societal costs. However, there is a lack of automatic fall detection systems for older adults. This paper reports (1) a wireless, flexible, skin-wearable electronic device for both accurate motion sensing and user comfort, and (2) a deep learning-based classification algorithm for reliable fall detection of older adults. The cost-effective skin-wearable motion monitoring device is designed and fabricated using thin copper films. It includes a six-axis motion sensor and is directly laminated on the skin without adhesives for the collection of accurate motion data. To study accurate fall detection using the proposed device, different deep learning models, body locations for the device placement, and input datasets are investigated using motion data based on various human activities. Our results indicate the optimal location to place the device is the chest, achieving accuracy of more than 98% for falls with motion data from older adults. Moreover, our results suggest a large motion dataset directly collected from older adults is essential to improve the accuracy of fall detection for the older adult population.

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“…Changes in the properties of the SC occur during aging. A decline in structural and functional properties could enhance penetration leading to an irritant or allergic contact dermatitis [20]. Current protective creams are still not perfect and are regarded with skepticism, because they may only be partially beneficial or even have detrimental side-effects [12].…”

Section: Discussionmentioning

confidence: 99%

Diffusion of Water across Human Skin in the Presence of Two Barrier Creams

Bijl

Eyk²,

Cilliers³

et al. 2000

Skin Pharmacol Physiol

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The in vitro permeability of tritiated water through fresh and frozen human skin was evaluated in the presence and absence of two different barrier creams. Treated (10 min) and untreated fresh and frozen human skin disks (4 mm in diameter) were mounted in flow cells of a continuous flow-through diffusion apparatus. Buffer/tritiated water was collected from the acceptor chambers at 2-hour intervals for a total of 20 h and counted in a liquid scintillation counter. The results indicated that both barrier creams lowered the average flux rates of tritiated water through fresh and frozen skin, but no significant differences could be detected between the two preparations. However, different results may be obtained when compounds with molecular weights much higher than water are used.

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Cumulative irritation in older and younger human skin - a comparison

Cited by 3 publications

References 0 publications

Anti‐Aging Data and Support Claims – Consensus Statement

Anti‐Aging Data and Support Claims – Consensus Statement

Experimental Study: Deep Learning-Based Fall Monitoring among Older Adults with Skin-Wearable Electronics

Diffusion of Water across Human Skin in the Presence of Two Barrier Creams

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