Cumulative Incidence of False-Positive Test Results in Lung Cancer Screening

Croswell, Jennifer M.

doi:10.7326/0003-4819-152-8-201004200-00007

Cited by 143 publications

(121 citation statements)

References 40 publications

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“…10), which dictates that many individuals require follow-up examinations and a substantial proportion of individuals undergo unnecessary thoracotomy (18). A recent manuscript by the Lung Screening Study reported that up to 7% of patients who were screened by CT underwent some level of invasive procedure (19). This suggests that a test with a higher specificity than CT that can identify high-risk individuals with early-stage disease would be a valuable aid to the early detection of lung cancer.…”

Section: Introductionmentioning

confidence: 99%

EarlyCDT-Lung: An Immunobiomarker Test as an Aid to Early Detection of Lung Cancer

Lam

Boyle

Healey

et al. 2011

Cancer Prevention Research

128

100

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Recent publications have reported the technical and clinical validation of EarlyCDT-Lung, an autoantibody test which detected elevated autoantibodies in 40% of lung cancers at diagnosis. This manuscript reports the results of EarlyCDT-Lung run on four new (postvalidation) data sets. The following four cohorts of patients (n ¼ 574) with newly diagnosed lung cancer were identified: group 1 (n ¼ 122), 100% small cell lung cancer (SCLC); group 2 (n ¼ 249), 97% non-small cell lung cancer (NSCLC); group 3 (n ¼ 122), 100% NSCLC; group 4 (n ¼ 81), 62% NSCLC. Serum samples were obtained after diagnosis, prior to any anticancer treatment. Autoantibody levels were measured against a panel of six tumor-related antigens (p53, NY-ESO-1, CAGE, GBU4-5, Annexin 1, and SOX2) in the EarlyCDT-Lung panel and previously established cutoffs applied. In groups 2, 3, and 4, patients were individually matched by gender, age, and smoking history to a control individual with no history of malignant disease. Assay sensitivity was tested in relation to cancer type and stage, and in the matched normals to demographic variables. The autoantibody panel showed sensitivity/specificity of 57%/n.d (not done) for SCLC in group 1, 34%/87% for NSCLC in group 2, 31% and 84% for NSCLC in group 3, and 35%/89% for NSCLC and 43%/89% for SCLC in group 4. There was no significant difference in positivity of EarlyCDT-Lung and different lung cancer stages. These studies confirm the value of an autoantibody assay, EarlyCDT-Lung, as an aid to detecting lung cancer in patients at high risk of the disease. Cancer Prev Res; 4(7); 1126-34. Ó2011 AACR.

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Section: Introductionmentioning

confidence: 99%

EarlyCDT-Lung: An Immunobiomarker Test as an Aid to Early Detection of Lung Cancer

Lam

Boyle

Healey

et al. 2011

Cancer Prevention Research

128

100

View full text Add to dashboard Cite

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“…Data from the International Commission on Radiological Protection indicated three male or six female cases of radiation-induced cancer would occur in every 100,000 screened individuals over 15-20 years [33]. Recent estimates have suggested the falsepositive rate of CT varied from 10 to 42 %, compared with 3 to 19 % for CXR [34,35]. As a less radioactive method than CT, but much more sensitive than CXR, DR may integrate both of the advantages.…”

Section: Discussionmentioning

confidence: 99%

Early Lung Cancer Detection Using the Self-Evaluation Scoring Questionnaire and Chest Digital Radiography: A 3-Year Follow-up Study in China

et al. 2012

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The standard definition of high-risk individuals for lung cancer was not uniform and the value of chest digital radiography (DR) in lung cancer screening was still unproven. The aim of this study was to assess whether the original questionnaire named as "Self-evaluation Scoring Questionnaire for High-risk Individuals of Lung Cancer" combined with DR examinations could detect early stage of lung cancer effectively. The Self-evaluation Scoring Questionnaire for High-risk Individuals of Lung Cancer had been designed in previous studies. Subjects with scores over 116 points were regarded as high-risk individuals and underwent the current DR scans at least once a year from 2007 to 2009. Noncalcified nodules with a diameter over 30 mm, along with enlarged pulmonary hilus and atelectasis, were considered to be positive and subjected to further special examinations. Efficacy of the scoring questionnaire combined with DR scans was estimated by 3-year results. Among 1,537 subjects, 13, 11, and 7 were diagnosed with lung cancer in the first, second, J Digit Imaging (2013) 26:72-81 DOI 10.1007 and third year, respectively, indicating the detection rate of 2.02 % (31/1,537). In addition, 77.42 % (24/31) of the patients were in stage I and 51.61 % (16/31) were adenocarcinomas. For the 31 cases, 28 were defined as detected cancers, while the other three were interval ones, only accounting for 0.20 % (3/1,504) of individuals with negative judgments. The protocol of Self-evaluation Scoring Questionnaire for High-risk Individuals of Lung Cancer combined with DR scans is a cost-effective and safe approach to detect early stage of lung cancer.

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“…Up to one-third of all CT scans require some type of follow-up imaging [24][25][26], which further increases the risks of the reactions noted above and of the patient potentially developing cancer in the future secondary to the radiation from the imaging. Incidental findings can also increase a patient's anxiety and fear, and the evaluation of incidental findings may require that additional procedures be performed-again exposing the patient to various risks and requiring further investments of time, energy, and money.…”

Section: The Most Commonly Requested Imaging Tests In Primarymentioning

confidence: 99%