Cumulative evidence for the relationship between body mass index and the risk of esophageal cancer: An updated meta‐analysis with evidence from 25 observational studies

Tian, Jie; Zuo, Chunjian; Liu, Guanchu; Che, Pengyu; Li, Gang; Li, Xiang; Chen, Huanwen

doi:10.1111/jgh.14917

Cited by 26 publications

(21 citation statements)

References 56 publications

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“…Considering that obesity also increases the risk of gastroesophageal reflux disease and BE, the obesity epidemic is closely associated with the increased incidence of esophageal adenocarcinoma globally [2,[56][57][58]. A meta-analysis from 25 epidemiological studies revealed that obesity increased the risk of EC, particularly esophageal adenocarcinoma [59]. There is a strong positive relationship between higher BMI and the risk of esophageal adenocarcinoma [60,61].…”

Section: Sex Differences In Esophageal Cancer Incidencementioning

confidence: 99%

Sex Differences in the Incidence of Obesity-Related Gastrointestinal Cancer

Heo

Kim

Sung

2021

IJMS

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Cancer is the second leading cause of death worldwide, with 9.6 million people estimated to have died of cancer in 2018. Excess body fat deposition is a risk factor for many types of cancer. Men and women exhibit differences in body fat distribution and energy homeostasis regulation. This systematic review aimed to understand why sex disparities in obesity are associated with sex differences in the incidence of gastrointestinal cancers. Cancers of the esophagus, liver, and colon are representative gastrointestinal cancers, and obesity is a convincing risk factor for their development. Numerous epidemiological studies have found sex differences in the incidence of esophageal, liver, and colorectal cancers. We suggest that these sexual disparities are partly explained by the availability of estrogens and other genetic factors regulating inflammation, cell growth, and apoptosis. Sex differences in gut microbiota composition may contribute to differences in the incidence and phenotype of colorectal cancer. To establish successful practices in personalized nutrition and medicine, one should be aware of the sex differences in the pathophysiology and associated mechanisms of cancer development.

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Section: Sex Differences In Esophageal Cancer Incidencementioning

confidence: 99%

Sex Differences in the Incidence of Obesity-Related Gastrointestinal Cancer

Heo

Kim

Sung

2021

IJMS

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“…Weight and height did not show statistically signi cance association with EC in our study. A metaanalysis study showed high risk of obesity with EAC but inverse association to ESCC (33). Another study in Netherland also showed signi cant association between obesity and overweight with EC (34).…”

Section: Discussionmentioning

confidence: 95%

Socio-demographic risk factors of esophageal carcinoma: A case control study in a tertiary care hospital, Kabul Afghanistan

Saadaat¹,

Abdul‐Ghafar²,

Atta³

et al. 2020

Preprint

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Introduction Esophageal cancer (EC) is 7th most common cancer in world in term of incidence and 6th common cancer in term of mortality. In Afghanistan, EC is the most common cancer in males. The socio-demographic status has been known as associated factor for EC. We carried out this study to determine the associated risk factors with EC in a tertiary hospital in Kabul, Afghanistan. Methodology Unmatched case control study of socio-demographic risk factors and EC was conducted at French Medical Institute for Mother and Children (FMIC). We enrolled and analyzed 132 EC cases and 132 normal controls to find out the associated risk factors for EC Result In current study Esophageal Squamous Cell Carcinoma (ESCC) was the predominant EC type (75.8%). The mean age of the case group is 59.48 ± 9.9 years and in control group is 48.05 ± 11.02, (OR: 1.070, 95% CI, p-value <0.001). Majority of the cases group are male (69.6%) (OR: 3.538, 95% CI, p-value 0.022). Participants living in rural areas have the 25-times higher risk of EC than living in urban regions. Un-educated and lower education are highly associated with the risk of EC (OR: 11.21, 95% CI, p-value: <0.001) as well as, having low Socioeconomic status was also highly associated with the increased risk of EC (OR: 14.08, 95% CI, p-value: <0.001). Having family history in first degree family highly associated with the risk of EC (OR: 4.581, 95% CI, p-value <0.001). Although, the majority of the EC patients were unemployed (93.3%) of which 75% were farmer comparing to control which comprises 55.3% of unemployed statistically in multivariate analysis it showed no significant association with EC. In addition, living area according country zones and provinces, weight and height and ethnicity showed no significant association with EC. Conclusion The study concluded that EC is common cancer in older age groups and, predominance in males. In addition, living in rural areas, being un-educated or having lower education, belonging to low socioeconomic status, and having positive family history in first degree relatives are associated with high risk of EC in our study.

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“…While no signi cant association was found between overweight and esophageal cancer (RR: 1.14, 95%CI: 0.98-1.30). However, it's interesting that both overweight and obesity could increase risk of esophageal adenocarcinoma and decrease risk of esophageal squamous cell carcinoma according to subgroup analysis (22). Compared with normal weight, overweight and obesity were demonstrated to be related with a 4% (OR: 1.04, 95%CI: 0.96-1.12) and 13% (OR: 1.13, 95%CI: 1.03-1.24) increased risk of gastric cancer respectively.…”

Section: Association Between Bmi and Various Cancer Riskmentioning

confidence: 99%

Body Mass Index and Cancer Risk: An Umbrella Review of Meta-Analyses of Observational Studies

Chen

Liu

et al. 2023

Nutrition and Cancer

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Background: Increasing evidence indicates that obesity is a risk factor for various tumors. We aimed to clarify the evidence for association between body mass index (BMI) and cancer risk based on existing systematic review and meta-analyses. Methods: PubMed, Embase and Web of science were systematically searched to obtain systematic review and meta-analyses reporting association between BMI and cancer incidence. The methodological quality and strength of evidence of each meta-analysis were assessed by AMSTAR and GRADE respectively. We also assessed the heterogeneity and publication bias of all included meta-analyses.Results: Finally, 43 meta-analyses with 19 cancers were identi ed by this umbrella review. The result revealed that underweight was inversely associated with the incidence of brain tumors while was positively related to the risk of esophageal and lung cancer. Overweight would enhance the incidence of brain tumors, kidney cancer, endometrial cancer, ovarian cancer, multiple myeloma, bladder cancer and liver cancer. Obesity was related to the increased incidence of brain tumors, cervical cancer, kidney cancer, endometrial cancer, esophageal cancer, gastric cancer, ovarian cancer, multiple myeloma, gallbladder cancer, bladder cancer, colorectal cancer, liver cancer, thyroid cancer and Hodgkin's lymphoma. What's more, dose-response analysis was conducted by 10 studies and the results demonstrated that per 5Kg/m 2 increment of BMI was associated with 1.01 to 1.13 fold increased risk of general brain tumors, multiple myeloma, bladder cancer, pancreatic cancer, breast cancer, Non-Hodgkin's lymphoma. And every 1Kg/m 2 increment of BMI was linked to 6% and 4% increment in the risk of kidney cancer and gallbladder cancer respectively.Conclusions: The evidence presented in this umbrella review showed that overweight and obesity were associated with increased risk of most cancers. We recommend that it is better to maintain BMI within the normal range to prevent the occurrence of tumors. However, prospective studies with high quality are needed to further investigate the association between BMI and various cancer risk.

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Cumulative evidence for the relationship between body mass index and the risk of esophageal cancer: An updated meta‐analysis with evidence from 25 observational studies

Cited by 26 publications

References 56 publications

Sex Differences in the Incidence of Obesity-Related Gastrointestinal Cancer

Sex Differences in the Incidence of Obesity-Related Gastrointestinal Cancer

Socio-demographic risk factors of esophageal carcinoma: A case control study in a tertiary care hospital, Kabul Afghanistan

Body Mass Index and Cancer Risk: An Umbrella Review of Meta-Analyses of Observational Studies

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