Cumulative Evidence for Association of IL-10 -1082G &gt; A Polymorphism with Susceptibility to Recurrent Pregnancy Loss: A Systematic Review and Meta-Analysis

Soleimani-Jadidi, Sara; Abbasi, Hajar; Javaheri, Atiyeh; Behforouz, Athena; Zanbagh, Leila; Meibodi, Bahare; Hadadan, Amaneh; Tabatabaei, Razieh Sadat; Neámatzadeh, Hossein

doi:10.1080/15513815.2020.1716903

Cited by 5 publications

(3 citation statements)

References 39 publications

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“…The IL-10 promoter is highly polymorphic [17][18][19][20], and three single nucleotide polymorphisms (SNPs) at positions -1082G>A, -819C>T and -592C>A polymorphisms within the promoter region have been shown to correlate with IL-10 production (22,24,25). To date, several genetic epidemiology studies have assessed the association between IL-10 -1082G>A, -819C>T and -592C>A polymorphisms and pediatric asthma in different populations (26,27).…”

Section: F O R P U B L I C a T I O Nmentioning

confidence: 99%

Association of IL-10-1082G > A, -819C > T and -592C > A Polymorphisms with susceptibility to asthma in children: a Systematic Review and Meta-Analysis

Dastgheib

Aarafi

Bahrami

et al. 2022

Eur Ann Allergy Clin Immunol

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Studies evaluating the association of IL-10 polymorphisms with risk of pediatric asthma found inconsistent data. Here, we performed a meta-analysis to get a precise estimation of the associations. Relevant studies identified in the PubMed, Scopus, CNKI databases were used to perform a metaanalysis. A total of 23 case-control studies including nine studies with 1298 cases and 1079 controls on -1082G>A, four studies with 622 cases and 603 controls on -819C>T and ten studies with 1480 case and 1462 controls on -592C>A were selected. Overall, there was no a significant association between IL-10 polymorphisms with pediatric asthma risk in global population. When stratified by ethnicity, there was a significant association of IL-10 -1082G>A with pediatric asthma in Asians and Chinese. This meta-analysis result revealed that IL-10 -1082G>A, -819C>T and -592C>A polymorphisms were not associated with pediatric asthma risk in the global population.

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Section: F O R P U B L I C a T I O Nmentioning

confidence: 99%

Association of IL-10-1082G > A, -819C > T and -592C > A Polymorphisms with susceptibility to asthma in children: a Systematic Review and Meta-Analysis

Dastgheib

Aarafi

Bahrami

et al. 2022

Eur Ann Allergy Clin Immunol

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“…IL-10 is known to play a substantial role in inflammation and immune processes [24]. IL-10 has been reported to inhibit the production of proinflammatory cytokines tumor necrosis factor alpha (TNFα), interleukin 1α and β (IL1α and β), interleukin IL-6 (IL-6), and interleukin-8 (IL-8), while stimulating B-cell proliferations, differentiation, and production [25][26][27][28][29]. IL-10 is an immunomodulatory cytokine encoded by the IL-10 gene on chromosome 1q31-32, containing five exons separated by four introns, and its receptor is located on chromosome 11 [30][31][32].…”

Section: Introductionmentioning

confidence: 99%

Correlation between rs1800871, rs1800872 and rs1800896 Polymorphisms at IL-10 Gene and Lung Cancer Risk

Vakili,

Shirinzadeh-Dastgiri,

Ershadi

et al. 2024

Asian Pac J Cancer Prev

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Background: The tumorigenesis of lung cancer is complicated, and genetic factor may have the role in the malignant transformation of lung cells. IL-10 gene polymorphisms have been evaluated for their potential roles in lung cancer. However, those studies results are controversial. To clarify the effects of IL-10 rs1800871, rs1800872 and rs1800896 polymorphisms on the risk of lung cancer, a meta-analysis was performed with eligible individual studies. Methods: Eligible publications were gathered by retrieving PubMed, Web of Science, Embase, Wan Fang, and CNKI up to September 01, 2023. The pooled odds ratios (ORs) with 95% confidence intervals (CIs) were used to assess the strength of such association. Results: A total of 23 studies, including 5950 patients with lung cancer and 8046 healthy controls, were identified in this meta-analysis. Overall, there was no a significant association between the rs1800871, rs1800872 and rs1800896 polymorphisms at IL-10 gene and susceptibility to lung cancer globally when all studies in the pooled into this meta-analysis. Stratified analysis by ethnicity showed that rs1800872 polymorphism was associated with lung cancer among Asians and Caucasians. However, no significant association was identified between the rs1800871 and rs1800896 and risk of lung cancer. Conclusions: Pooled data showed that IL-10 rs1800871, rs1800872 and rs1800896 polymorphisms were not associated with lung cancer globally. Future well-designed large case-control studies with different ethnicities are recommended.

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“…Recurrent pregnancy loss (RPL) is one of the main public health issues with a rate of 5% among women of reproductive age ( 1 , 2 ) . RPL is defined as the loss of three or more successive pregnancies before viability and includes all pregnancy losses from the time of conception until 24 weeks of gestation ( 3 , 4 , 5 ) . The most commonly cited causes of miscarriage are structural chromosome abnormalities of one of the partners, uterine abnormalities, elevated random levels of homocysteine, and antiphospholipid syndrome ( 6 , 7 ) .…”

Section: Introductionmentioning

confidence: 99%

A meta-analysis of the association of the ACE I/D and PAI-1 4G/5G polymorphisms with recurrent pregnancy loss in Iranian women: Are the investigations adequate?

Dastgheib¹,

Karimi-Zarchi²,

Bahrami³

et al. 2021

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The associations of ACE I/D and PAI-1 4G/5G polymorphisms with recurrent pregnancy loss (RPL) in Iranian women have yielded controversial results. Thus, we conducted a meta-analysis to obtain more certain results. A comprehensive literature search was performed in the PubMed, Web of Sciences, Scopus, MedRxiv, SID, and CNKI databases up to January 1st, 2021, using the appropriate terms. All case-control studies were included. Odds ratios (ORs) and 95% confidence intervals (CIs) were used to estimate the strength of associations. A total of 14 studies including eight studies with 783 patients and 761 healthy subjects on ACE I/D and six studies with 1.155 patients and 699 healthy subjects on PAI-1 4G/5G were included. Combined data revealed that ACE I/D polymorphism was significantly associated with RPL risk in Iranian women under three models i.e., allele [OR=0.744, 95% CI: (0.640-0.864); p≤0.001], dominant [OR=0.774, 95% CI: (0.601-0.996); p=0.047], and recessive [OR=0.767, 95% CI: (0.611-0.963); p=0.022]. Moreover, the pooled data showed a significant association between the PAI-1 4G/5G polymorphism and RPL risk under all five models i.e., allele [OR=2.352, 95% CI: (1.623-3.408); p≤0.001], heterozygote [OR=8.364, 95% CI: (4.744-14.756); p≤0.001), homozygote [OR=2.192, 95% CI: (1.093-4.394); p=0.027), dominant [OR=2.354, 95% CI: (1.309-4.235); p=0.004], and recessive [OR=5.208, 95% CI: (3.005-9.025); p≤0.001]. Stratification analysis revealed that these polymorphisms were associated with RPL risk by the number of miscarriages. Our pooled data indicated that ACE I/D and PAI-1 4G/5G polymorphisms were significantly associated with an increased risk of RPL in Iranian women. These significant findings showed that the investigation might be adequate for ACE I/D and PAI-1 4G/5G polymorphisms in the Iranian population.

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Cumulative Evidence for Association of IL-10 -1082G > A Polymorphism with Susceptibility to Recurrent Pregnancy Loss: A Systematic Review and Meta-Analysis

Cited by 5 publications

References 39 publications

Association of IL-10-1082G > A, -819C > T and -592C > A Polymorphisms with susceptibility to asthma in children: a Systematic Review and Meta-Analysis

Association of IL-10-1082G > A, -819C > T and -592C > A Polymorphisms with susceptibility to asthma in children: a Systematic Review and Meta-Analysis

Correlation between rs1800871, rs1800872 and rs1800896 Polymorphisms at IL-10 Gene and Lung Cancer Risk

A meta-analysis of the association of the ACE I/D and PAI-1 4G/5G polymorphisms with recurrent pregnancy loss in Iranian women: Are the investigations adequate?

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