Cumulative Evidence for Association between IL-10 Polymorphisms and Kawasaki Disease Susceptibility: A Systematic Review and Meta-Analysis

Ferdosian, Farzad; Dastgheib, Seyed Alireza; Morovati-Sharifabad, Majid; Lookzadeh, Mohammad Hosein; Noorishadkam, Mahmood; Mirjalili, Seyed Reza; Akbarian-Bafghi, Mohammad Javad; Neámatzadeh, Hossein

doi:10.1080/15513815.2019.1686789

Cited by 9 publications

(8 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although intravenous immunoglobulin (IVIG) is applied as the initial treatment, between 10 and 20% of patients develop coronary vasculitis and, thus, have an increased risk of cardiovascular disease during their lifetime. 4,5) Despite extensive research, the etiology of KD remains unclear. Recent advances have increased the accuracy of diagnoses and resulted in the development of therapeutic strategies for better acute as well as long-term outcomes.…”

Section: Introductionmentioning

confidence: 99%

Coronary Vasculitis Induced in Mice by the Cell Wall Mannoprotein of <i>Candida krusei</i>

Yanai

Tanaka

Miura

et al. 2020

Biological & Pharmaceutical Bulletin

View full text Add to dashboard Cite

Kawasaki disease (KD) is an inflammatory disease that was identified by Professor Tomisaku Kawasaki in 1961. Candida albicans-derived substances, such as the hot water extract of C. albicans (CADS) and Candida water-soluble fraction (CAWS), induced coronary vasculitis similar to KD in mice. An increasing proportion of deep-seated candidiasis cases are caused by non-albicans Candida and are often resistant to antifungal drugs. We herein investigated whether the hot water extract of C. krusei, inherently resistant to fluconazole, induces vasculitis in mice. Three strains of C. krusei, NBRC1395, NBRC1162, and NBRC10737, were cultured in natural (Y) and chemically defined (C) media and cell wall mannoprotein (MN) fractions were prepared by autoclaving cells (CKY1395MN, CKC1395MN, CKY1162MN, CKC1162MN, CKY10737MN, and CKC10737MN). All MN fractions reacted strongly with Con A and dectin-2 and induced anaphylactoid shock in ICR mice. MNs induced severe coronary vasculitis in DBA/2 mice, resulting in cardiac hypertrophy. MNs also induced coronary vasculitis in C57Bl/6 mice. These results suggest that the MNs of non-albicans Candida, such as C. krusei, induce similar toxicity to those of C. albicans.

show abstract

Section: Introductionmentioning

confidence: 99%

Coronary Vasculitis Induced in Mice by the Cell Wall Mannoprotein of <i>Candida krusei</i>

Yanai

Tanaka

Miura

et al. 2020

Biological & Pharmaceutical Bulletin

View full text Add to dashboard Cite

show abstract

“…Many studies have suggested that IL-10 is an important cytokine in the pathogenesis of KD. 33 The IL-10 gene not only showed different SNV sites between KD group and control group, but also had decreased protein expression. IL-10 plays an important role in the immunoregulation and immunotherapy through Treg cells.…”

Section: Discussionmentioning

confidence: 95%

eQTL Highlights the Potential Role of Negative Control of Innate Immunity in Kawasaki Disease

Song

Chen

Ning

et al. 2022

IJGM

View full text Add to dashboard Cite

Purpose Kawasaki disease (KD) is an acute systemic vasculitis mainly found in the medium-sized arteries, especially the coronary arteries. Immune system is involved in the pathogenesis of acute KD in children, but the functional differences in the immune system between healthy children and KD patients remain unclear. Patients and Methods A total of 190 KD patients and 119 healthy controls were recruited for the next-generation sequencing of 512 targeted genes from 4 immune-related pathways. Subsequently, the peripheral blood mononuclear cells (PBMCs) were isolated. RNA sequencing of the LPS treated PBMCs from additional 20 KD patients and 20 healthy controls was used to examine the differentially expressed genes (DEGs). Then, an expression quantitative trait locus (eQTL) analysis combined with previously analyzed RNA data were used to examine the DEGs. Finally, the serum levels of 13 cytokines were detected before and after LPS treatment in 40 samples to confirm the findings from eQTL analysis. Results A total of 319 significant eQTL were found, and both eQTL analysis and RNA sequencing showed some DEGs were involved in the connective tissue disorders and inflammatory diseases. DEGs that function to negatively regulate immunity were closely related to the pathogenesis of KD. In addition, the serum levels of IL-10 (an inflammatory and immunosuppressive factor) and SCD25 (an important immunosuppressant) reduced significantly in the KD patients. Conclusion Our study shows the expression of factors responsible for the negative control of innate immunity is altered, which plays an important role in the etiology of KD.

show abstract

“…The IL-10 promoter is highly polymorphic [17][18][19][20], and three single nucleotide polymorphisms (SNPs) at positions -1082G>A, -819C>T and -592C>A polymorphisms within the promoter region have been shown to correlate with IL-10 production (22,24,25). To date, several genetic epidemiology studies have assessed the association between IL-10 -1082G>A, -819C>T and -592C>A polymorphisms and pediatric asthma in different populations (26,27).…”

Section: F O R P U B L I C a T I O Nmentioning

confidence: 99%

“…Moreover, IL-10 is known to have macrophage-deactivating properties and undermines the Th1-driven pro-inflammatory response by down-regulating the production of several cytokines (17,18). Human IL-10 gene maps to chromosome 1q31-32, contains four introns and five exons, and spans about 4.7 kb (19).…”

Section: Introductionmentioning

confidence: 99%

Association of IL-10-1082G > A, -819C > T and -592C > A Polymorphisms with susceptibility to asthma in children: a Systematic Review and Meta-Analysis

Dastgheib

Aarafi

Bahrami

et al. 2022

Eur Ann Allergy Clin Immunol

View full text Add to dashboard Cite

Studies evaluating the association of IL-10 polymorphisms with risk of pediatric asthma found inconsistent data. Here, we performed a meta-analysis to get a precise estimation of the associations. Relevant studies identified in the PubMed, Scopus, CNKI databases were used to perform a metaanalysis. A total of 23 case-control studies including nine studies with 1298 cases and 1079 controls on -1082G>A, four studies with 622 cases and 603 controls on -819C>T and ten studies with 1480 case and 1462 controls on -592C>A were selected. Overall, there was no a significant association between IL-10 polymorphisms with pediatric asthma risk in global population. When stratified by ethnicity, there was a significant association of IL-10 -1082G>A with pediatric asthma in Asians and Chinese. This meta-analysis result revealed that IL-10 -1082G>A, -819C>T and -592C>A polymorphisms were not associated with pediatric asthma risk in the global population.

show abstract

Cumulative Evidence for Association between IL-10 Polymorphisms and Kawasaki Disease Susceptibility: A Systematic Review and Meta-Analysis

Cited by 9 publications

References 31 publications

Coronary Vasculitis Induced in Mice by the Cell Wall Mannoprotein of <i>Candida krusei</i>

Coronary Vasculitis Induced in Mice by the Cell Wall Mannoprotein of <i>Candida krusei</i>

eQTL Highlights the Potential Role of Negative Control of Innate Immunity in Kawasaki Disease

Association of IL-10-1082G > A, -819C > T and -592C > A Polymorphisms with susceptibility to asthma in children: a Systematic Review and Meta-Analysis

Contact Info

Product

Resources

About