Cumulative Effect of Visual Impairment, Multimorbidity, and Frailty on Intrinsic Capacity in Community-Dwelling Older Adults

Ho, Vanda; Chen, Cynthia; Merchant, Reshma Aziz

doi:10.1177/0898264319847818

Cited by 22 publications

(14 citation statements)

References 25 publications

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“…Interestingly, no significant difference in handgrip strength was observed in individuals with a single sensory impairment compared with no impairment. Two other studies 38,40 also found no association between VI (both self‐reported and objectively measured) and weak handgrip strength; however, Vancampfort and associates 38 reported that individuals with HI (based on an interviewer's observation during the survey) had higher odds of weak handgrip strength (OR 1.40; 95% CI: 1.16 to 1.70; P < 0.001).…”

Section: Resultsmentioning

confidence: 95%

“…Four studies drew from Asian populations, seven from Caucasian populations and two from a combination of multiple ethnicities from six low‐ and middle‐income countries (LMIC). Two studies 30 , 38 had a moderate (NOS 5–7) and the remaining 22 , 23 , 28 , 29 , 31 , 32 , 33 , 34 , 39 , 40 , 41 ( n = 11) had a low (NOS ≥ 8) risk of bias ( Table 2 for longitudinal studies; Table 3 for cross‐sectional studies).…”

Section: Resultsmentioning

confidence: 99%

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Association between age‐related sensory impairment with sarcopenia and its related components in older adults: a systematic review

Gupta

Fenwick

et al. 2022

J cachexia sarcopenia muscle

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Sensory impairments and sarcopenia are both highly prevalent age‐related conditions, with the former having been postulated to contribute to the pathogenesis of the latter condition. Confirming this hypothesis may therefore help to better inform strategies for early treatment and intervention of sarcopenia. We performed a systematic review of the current literature examining the relationships between four major sensory impairments [vision (VI), hearing (HI), smell (SI), and taste (TI)] with (i) sarcopenia; and (ii) its associated components (low handgrip strength, slow gait speed, and low muscle mass). PubMed, EMBASE, CINAHL, and Cochrane Library databases were searched for observational studies investigating the relationship of VI, HI, SI, and TI with sarcopenia, low handgrip strength, slow gait speed, and low muscle mass, in adults aged 50 years or older, from inception until 24 May 2021. The risk of bias of the included studies was assessed using the Newcastle‐Ottawa Scale. This study was registered with PROSPERO, reference CRD42021247967. Ten cross‐sectional and three longitudinal population‐based studies of community‐dwelling adults (N = 68 235) were included, with five studies investigating more than one sensory impairment. In total, 8, 6, 3, and 1 studies investigated the relationship between VI, HI, SI, and TI and sarcopenia and its related components, respectively. Follow‐up duration for the longitudinal studies ranged from 4 to 11 years. All studies had a low or moderate risk of bias. We found that the presence of VI and SI, but not TI, independently increased the odds of sarcopenia. In addition, VI and SI were each independently associated with low muscle mass; and VI, HI, and SI were each independently associated with slow gait speed. However, we found inconclusive evidence for the associations between VI, HI and SI, and low handgrip strength. Our systematic review suggests a potential association between the presence of single or multiple sensory impairments and a greater likelihood of sarcopenia and/or deficits in its associated components, especially for VI, HI, and SI. Prospective studies are needed to untangle the relationship between sensory impairment and sarcopenia to better inform clinical guidelines for disease prevention and management.

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Section: Resultsmentioning

confidence: 95%

Section: Resultsmentioning

confidence: 99%

Association between age‐related sensory impairment with sarcopenia and its related components in older adults: a systematic review

Gupta

Fenwick

et al. 2022

J cachexia sarcopenia muscle

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“…A total of 39 articles describing 34 studies with 59,944 participants from six ASEAN countries were included in the review (Figure 1) as data from three cohorts were reported in several publications. (12)(13)(14)(15)(16)(17)(18)(19) Twenty-five studies were included in the meta-analysis. (14,17,18,)…”

Section: Resultsmentioning

confidence: 99%

The prevalence of functional disability and its impact on older adults in the ASEAN region: a systematic review and meta-analysis

et al. 2022

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Objectives: Functional disability is a common consequence of the ageing process and can lead to poor health outcomes due to the inability to perform activities of daily living (ADL) and instrumental ADL (IADL) independently. However, the prevalence of functional disability among older adults in the ASEAN region is poorly documented. This study aims to assess the prevalence of functional disability and its impact on older adults in the ASEAN region.Methods: A systematic literature search was performed on four databases from inception until March 2021 to identify for studies examining individuals aged 60 years and above reporting functional disabilities in the ASEAN region. Prevalence and impact of functional disability were extracted, assessed for bias, summarised and analysed using random-effects meta-analysis.Results: Thirty-four studies reporting 59,944 participants were included. Pooled prevalence of found that ADL disability was 21.5% (95% confidence interval: 16.2% to 27.3%) and IADL disability was 46.8% (35.5% to 58.3%). Subgroup analyses showed higher prevalence among those of advanced age and females. Adverse impacts include increased years of life with disability and poor health-related quality of life.Conclusions: Functional disability is experienced by nearly a quarter of the older adult population in the ASEAN region. Findings highlight the need for further research on functional disability burden and impact within this region to allow decision makers to gauge the severity of the issue, to develop policies to reduce the risk of developing functional disabilities and foster healthy ageing.

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“…And recently, a few studies have focused on these components together as IC composite concept in community-dwelling and nursing home older residents [14, 15]. The Healthy Older People Everyday (HOPE) study comprising 1,051 community-dwelling older adults revealed a combined effect of vision impairment, multimorbidity, and frailty on IC [14]. Another cohort study among Belgian nursing home residents showed that poor nutrition status and low balance performance, which composed of 2 domains of IC, predicted the incidence of 3-year mortality, and poor nutrition status also predicted 3-year autonomy decline [15].…”

Section: Introductionmentioning

confidence: 99%

The Impact of Intrinsic Capacity on Adverse Outcomes in Older Hospitalized Patients: A One-Year Follow-Up Study

Zeng

Shen

et al. 2021

Gerontology

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Background: Intrinsic capacity (IC) is a novel view focusing on healthy aging. The effect of IC on adverse outcomes in older hospitalized Chinese adults is rarely studied. Objectives: This study focused on investigating the impact of IC domains on the adverse health outcomes including new activities of daily living (ADL) dependency, new instrumental activities of daily living (IADL) dependency, and mortality over a 1-year follow-up. Methods: In a retrospective observational population-based study, a total of 329 older hospitalized patients from Zhejiang Hospital in China were enrolled and completed 1-year follow-up. The 5 domains of IC including cognition, locomotion, sensory, vitality, and psychological capacity were assessed at admission. The IC composite score was calculated based on these domains, and the higher IC composite score indicated the greater amount of functional capacities reserved. Multivariate logistic regression models were used to explore the association between IC at baseline and 1-year adverse outcomes. Results: During the 1-year follow-up, 69 patients (22.5%) experienced new ADL dependency, 103 patients (33.6%) suffered from new IADL dependency, and 22 patients (6.7%) died. After adjusting for age, sex, education level, comorbidities, and polypharmacy, low Mini-Mental State Examination (MMSE) scores at admission predicted 1-year new ADL dependency (odds ratio [OR] = 2.31, 95% confidence interval [CI]: 1.12–4.78) and new IADL dependency (OR = 2.15, 95% CI: 1.14–4.04) among older hospitalized patients, but no significance was obtained between IC domains and mortality. Higher IC composite score at admission was associated with decreased risks of 1-year new ADL dependency (OR = 0.53, 95% CI: 0.40–0.70) and new IADL dependency (OR = 0.76, 95% CI: 0.61–0.95), and 1-year mortality (OR = 0.48, 95% CI: 0.31–0.74) after adjustment for the possible confounders. Conclusions: Loss of ICs at admission predicted adverse health outcomes including new ADL and IADL dependency and mortality 1 year after discharge among older hospitalized patients.

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Cumulative Effect of Visual Impairment, Multimorbidity, and Frailty on Intrinsic Capacity in Community-Dwelling Older Adults

Cited by 22 publications

References 25 publications

Association between age‐related sensory impairment with sarcopenia and its related components in older adults: a systematic review

Association between age‐related sensory impairment with sarcopenia and its related components in older adults: a systematic review

The prevalence of functional disability and its impact on older adults in the ASEAN region: a systematic review and meta-analysis

The Impact of Intrinsic Capacity on Adverse Outcomes in Older Hospitalized Patients: A One-Year Follow-Up Study

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