Cumulative dose of radiation therapy of hepatocellular carcinoma patients and its deterministic relation to radiation-induced liver disease

Huang, Pu; Yu, Gang; Kapp, Daniel S.; Bian, Xuefeng; Ma, Changsheng; Li, Hongsheng; Chen, Jinhu; Liang, Yueqiang; Zhang, Yang; Qin, Shaohua; Xie, Yaoqin; Yang, Yong; Yin, Yong; Liu, Xing; Li, Deng-Wang

doi:10.1016/j.meddos.2017.10.002

Cited by 5 publications

(7 citation statements)

References 37 publications

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“…The target tracking dose is delivered throughout the breathing cycle. The larger volume of the liver at the end of expiration has been shown to reduce the dose to the liver for a given beam aperture …”

Section: Discussionmentioning

confidence: 99%

“…The larger volume of the liver at the end of expiration has been shown to reduce the dose to the liver for a given beam aperture. 11,[17][18][19][20][21][22] In MIM Maestro, a rigid registration is initially applied, which is followed by a nonrigid registration. In this study, the rigid registration was defined automatically using the whole body as a starting point of the ROI for deformation.…”

Section: Discussionmentioning

confidence: 99%

“…The three parameters were derived according to Burman identification; several parameters, including mean hepatic dose, percent volume of normal liver with radiation dose more than 30 Gy (V30 Gy), and NTCP were calculated from the DVH. The NTCP model of Lyman was used . In the NTCP model.

\begin{matrix} N T C P = 1 / \sqrt{2 π} \int_{- \infty}^{t} exp false(- t^{2} true/ 2 false) d t \\ t = false(D - T D_{50} (v) false) / false(m \times T D_{50} (v) false) \end{matrix}

v = V / V_{ref}

…”

Section: Methodsmentioning

confidence: 99%

“…4D plan design: ① Each 4D phase plan was designed with the same field angles as those used in the 3D plan. The 22,26 In the NTCP model. The dose for the left and right kidney and the maximum dose for the bowel, duodenum, esophagus, stomach, and heart were evaluated.…”

Section: B | 4dct Simulation and Planning Target Volume (Ptv) Acquimentioning

confidence: 99%

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Dosimetric study of three‐dimensional static and dynamic SBRT radiotherapy for hepatocellular carcinoma based on 4DCT image deformable registration

Duan

et al. 2019

J Applied Clin Med Phys

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The purpose of this work was to determine the actual dose received by normal tissues during four‐dimensional radiation therapy (4DRT) composed of ten phases of four‐dimensional computer tomography (4DCT) images. The analysis was performed by tracking the hepatocellular carcinoma SBRT. Data were acquired from the tracking of each phase with the beam aperture for 28 hepatocellular carcinoma patients, and the data were used to generate a cumulative plan, which was compared to a three‐dimensional (3D) plan formed from a merged target volume based on 4DCT images in a radiation treatment planning system (TPS). The change in normal tissue dose was evaluated in the plan using the parameters V5, V10, V15, V20, V25, V30, V35, and V40 (volumes receiving 5, 10, 15, 20, 25, 30, 35, and 40 Gy, respectively) in the dose‐volume histogram for the liver; the mean dose was analyzed for the following tissues: liver, left kidney, and right kidney. The maximum dose was analyzed for the following tissues: bowel, duodenum, esophagus, stomach, and heart. There was a significant difference in the dose between the 4D planning target volume (PTV) (average 115.71 cm3) and ITV (169.86 cm3). The planning objective was for 95% of the volume of the PTV to be covered by the prescription dose, but the mean dose for the liver, left kidney and right kidney had an average decrease of 23.13%, 49.51%, and 54.38%, respectively. The maximum dose for the bowel, duodenum, esophagus, stomach, and heart had an average decrease of 16.77%, 28.07%, 24.28%, 4.89%, and 4.45%, respectively. Compared to 3D RT, the radiation volume for the liver V5, V10, V15, V20, V25, V30, V35, and V40 using the 4D plans had a significant decrease (P ﹤ 0.05). The 4D method creates plans that permit sparing of the normal tissues more than the commonly used ITV method, which delivers the same dosimetric effects to the target.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

\begin{matrix} N T C P = 1 / \sqrt{2 π} \int_{- \infty}^{t} exp false(- t^{2} true/ 2 false) d t \\ t = false(D - T D_{50} (v) false) / false(m \times T D_{50} (v) false) \end{matrix}

v = V / V_{ref}

…”

Section: Methodsmentioning

confidence: 99%

Section: B | 4dct Simulation and Planning Target Volume (Ptv) Acquimentioning

confidence: 99%

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Dosimetric study of three‐dimensional static and dynamic SBRT radiotherapy for hepatocellular carcinoma based on 4DCT image deformable registration

Duan

et al. 2019

J Applied Clin Med Phys

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“…Radiotherapy, such as 3-dimensional conformal radiotherapy (3-DCRT), intensity modulated radiotherapy (IMRT), image-guided radiotherapy (IGRT) or stereotactic body radiation therapy (SBRT), plays an important role in the treatment of HCC [2][3][4]; however, there are also many adverse effects in the practice of radiotherapy [5]. The failure of radiotherapy is always caused by the risk of radiation-induced hepatic toxicity [6,7]. HCC is usually accompanied by cirrhosis of the liver with poor hepatic function, which makes it di cult to treat with high-dose radiotherapy [8].…”

Section: Introductionmentioning

confidence: 99%

Silencing the Expression of Cyclin G1 Enhances the Radiosensitivity of Hepatocellular Carcinoma In Vitro and In Vivo by Inducing Apoptosis

Wang

et al. 2021

Radiation Research

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Background: Radiotherapy plays an important role in the treatment of hepatocellular carcinoma (HCC).Cyclin G1 was a novel member of the cyclin family, and it is abnormally expressed in HCC. The aim of this study was to investigate the role of cyclin G1 in the radiotherapy of HCC cells.Methods: The expression of cyclin G1 was silenced by transfection of cyclin G1-siRNA into HepG2 cells, and the expression of cyclin G1 mRNA and protein was measured by qRT-PCR and western blot analysis.The proliferation was analysed by MTT assay, and the radiosensitivity of HCC cells was detected by using a colony formation assay and a xenograft tumour model. The expression of apoptosis-related proteins (Bcl-2 and Bax) was detected by western blot analysis.Results: The expression of cyclin G1 mRNA and protein in HepG2-cyclin G1-siRNA cells is signi cantly decreased compared with that in HepG2 cells. Silencing the expression of cyclin G1 inhibits the proliferation of HCC cells and enhances the radiosensitivity of HepG2 cells in vitro and in vivo. HepG2cyclin G1-siRNA signi cantly decreases Bcl-2 expression and increases Bax expression in cells. Conclusion:Silencing the expression of cyclin G1 enhances the radiosensitivity of HCC cells in vitro and in vivo, and the mechanism is probably related to the regulation of apoptosis-related proteins.

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Vasculature-Driven Biomechanical Deformable Image Registration of Longitudinal Liver Cholangiocarcinoma Computed Tomographic Scans

Cazoulat

Elganainy

Anderson

et al. 2020

Advances in Radiation Oncology

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Deformable image registration (DIR) of longitudinal liver cancer computed tomographic (CT) images can be challenging owing to anatomic changes caused by radiation therapy (RT) or disease progression. We propose a workflow for the DIR of longitudinal contrast-enhanced CT scans of liver cancer based on a biomechanical model of the liver driven by boundary conditions on the liver surface and centerline of an autosegmentation of the vasculature. Methods and Materials: Pre-and post-RT CT scans acquired with a median gap of 112 (32-217) days for 28 patients who underwent RT for intrahepatic cholangiocarcinoma were retrospectively analyzed. For each patient, 5 corresponding anatomic landmarks in pre-and post-RT scans were identified in the liver by a clinical expert for evaluation of the accuracy of different DIR strategies. The first strategy corresponded to the use of a biomechanical model-based DIR method with boundary conditions specified on the liver surface (BM_DIR). The second strategy corresponded to the use of an expansion of BM_DIR consisting of the auto-segmentation of the liver vasculature to determine additional boundary Sources of support: Dr Cazoulat reports grants from

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Cumulative dose of radiation therapy of hepatocellular carcinoma patients and its deterministic relation to radiation-induced liver disease

Cited by 5 publications

References 37 publications

Dosimetric study of three‐dimensional static and dynamic SBRT radiotherapy for hepatocellular carcinoma based on 4DCT image deformable registration

Dosimetric study of three‐dimensional static and dynamic SBRT radiotherapy for hepatocellular carcinoma based on 4DCT image deformable registration

Silencing the Expression of Cyclin G1 Enhances the Radiosensitivity of Hepatocellular Carcinoma In Vitro and In Vivo by Inducing Apoptosis

Vasculature-Driven Biomechanical Deformable Image Registration of Longitudinal Liver Cholangiocarcinoma Computed Tomographic Scans

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