Cumulative damage and the response of human bone in two-step loading fatigue

Zioupos, Peter; Casinos, Adriá

doi:10.1016/s0021-9290(98)00102-x

Cited by 49 publications

(46 citation statements)

References 24 publications

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“…( 3 ) is only valid if the order in which the cycles are applied has no effect on the outcome. Very few experiments have been conducted to test this hypothesis ~ the only results found were due to Zioupos and Casinos [24] who imposed combinations of low-stress cycles and higherstress cycles in different sequences. They found that the 'high-low' sequence resulted in slightly shorter lives than the 'low-high' sequence.…”

Section: Theoretical Developmentmentioning

confidence: 99%

The prediction of stress fractures using a ‘stressed volume’ concept

Taylor

Kuiper

2001

Journal Orthopaedic Research

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This paper addresses an anomaly which exists in the current literature regarding stress fractures. Analysis of the data on fatigue strength of bone samples in vitro would conclude that these fractures should never occur at the strain levels known to occur in vivo. This anomaly can be resolved by including in the analysis the effect of stressed volume, whereby larger volumes of material are expected to have worse fatigue properties. A Weibull analysis was used to predict the probability of failure, pt; this was an upperbound prediction because it did not include the effects of remodelling and adaptation. Combining this analysis with a finite element model of the human tibia, we predicted a Pf value of 21% after five weeks of strenuous exercise, which is comparable with reported incidences in military personnel. The high incidence of stress fractures in the cannon bone of racehorses could also be predicted (Pr = 62'%, compared to 70% experimentally). The approach can be used to investigate the effect of variables in the exercise regime such as the distance run per day and the use of improved footwear. It can also predict the increased risk of stress fractures in elderly people. The results suggest certain simple rules which may be of clinical value in designing exercise regimes and in understanding the risk factors for this type of injury.

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Section: Theoretical Developmentmentioning

confidence: 99%

The prediction of stress fractures using a ‘stressed volume’ concept

Taylor

Kuiper

2001

Journal Orthopaedic Research

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“…Cyclic loading induced damage accumulation is also reported to weaken vertebrae (Burr et al, 1997) and is often associated with loosening of implants (Bauer and Schils, 1999). Whereas the fatigue strength of cortical bone is extensively reported in the literature (Carter et al, 1981;Zioupos and Casinos, 1998;Yeni and Fyhrie, 2002;O'Brien et al, 2003;Taylor et al, 2003;George and Vashishth, 2006) few data are available for trabecular bone (Moore and Gibson, 2003;Haddock et al, 2004;Yamamoto et al, 2006;Dendorfer et al, 2006). Most studies concentrate on bovine and human trabecular bone specimens cored in the main (onaxis) direction and analysed in cyclic compression.…”

Section: Introductionmentioning

confidence: 99%

Anisotropy of the fatigue behaviour of cancellous bone

Dendorfer

Maier

Taylor

et al. 2008

Journal of Biomechanics

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“…Specifically, the model aims to address the hypothesis that diffuse microdamage accumulation and concomitant modulus reduction, without the need for complete trabecular strut fracture, may be an underlining mechanism for lowcycle fatigue failure in high-density trabecular bone. Information about the gradual reduction in material properties offers important information about bone's fragile structural state prior to failure (Zioupos and Casinos, 1998). Furthermore, predicting the diffuse sites of microdamage initiation and evolution may provide important prerequisite information for use in remodeling simulations.…”

Section: Introductionmentioning

confidence: 99%