Cumulative Adversity and Smaller Gray Matter Volume in Medial Prefrontal, Anterior Cingulate, and Insula Regions

Ansell, Emily B.; Rando, Kenneth; Tuit, Keri; Guarnaccia, Joseph; Sinha, Rajita

doi:10.1016/j.biopsych.2011.11.022

Cited by 301 publications

(259 citation statements)

References 73 publications

Supporting

Mentioning

237

Contrasting

Order By: Relevance

“…In support of this idea are data suggesting a relationship between hippocampal volume and length of lifetime depression (Sheline et al, 1996). Cumulative stress and adversity are associated with changes in some brain regions (Ansell et al, 2012). Corticosteroid excess is associated with hippocampal atrophy in animal models and humans (Brown et al, 2004).…”

Section: Introductionmentioning

confidence: 93%

Association of Depressive Symptoms with Hippocampal Volume in 1936 Adults

Brown

Hughes

McColl

et al. 2013

Neuropsychopharmacol

View full text Add to dashboard Cite

Hippocampal atrophy is reported in major depressive disorder (MDD). However, sample sizes were generally modest, and participant characteristics, including age, differed between studies. This study used a community sample to examine relationships between current depressive symptom severity and hippocampal volume across the adult lifespan. A total of 1936 adults with magnetic resonance images of the brain and Quick Inventory of Depressive Symptomatology Self-Report (QIDS-SR) scores were included. Brain volumes were quantified using the FSL program. Multiple linear regressions were performed using left, right, and total hippocampal volume as criterion variables, and predictor variables of QIDS-SR total, total brain volume, age, gender, education, psychotropic medications, alcohol use, and race/ethnicity. Post hoc analyses were conducted in participants with QIDS-SR scores X11 (moderate or greater depressive symptom severity) and o11, and older and younger adults. In the primary analysis (sample as a whole) QIDS-SR was inversely associated with total hippocampal volume (b ¼ À 0.044, p ¼ 0.032, (CI À 0.019 to À 0.001)) but not with left or right hippocampal volume evaluated individually. In participants with QIDS-SR scores of o11, hippocampal volumes were not associated with QIDS-SR scores. In those with QIDS-SR scores X11 total, right, and left hippocampal volumes were modestly, but significantly, associated with QIDS-SR scores. The association between QIDS-SR scores and the hippocampal volume was much stronger in older persons. Findings suggest smaller hippocampal volumes among those with greater reported depressive symptom severity-an association that is strongest in people with at least moderate depressive symptom levels.

show abstract

Section: Introductionmentioning

confidence: 93%

Association of Depressive Symptoms with Hippocampal Volume in 1936 Adults

Brown

Hughes

McColl

et al. 2013

Neuropsychopharmacol

View full text Add to dashboard Cite

show abstract

“…As reported here (Table 2) and in an earlier report involving 56 patients of this cohort (Kumari et al, 2013), a higher proportion of ASPD and VSZ patients had suffered significant psychosocial deprivation, in particular severe physical and/or sexual abuse as children, and there was a direct negative correlation between the AC volume bilaterally and psychosocial deprivation (total) as well as physical and sexual abuse ratings across the whole sample. The AC is highly vulnerable to stress-related changes in noradrenergic activity (Hermans et al, 2011) and, like the hippocampus, shows grey matter loss following a variety of stressful conditions, including childhood adversity, in individuals with or without a PTSD diagnosis (Ansell et al, 2012;Dannlowski et al, 2012;Karl et al, 2006). Although the current study is unable to conclusively inform about the direction of causality in the observed relationship between AC volume and psychosocial deprivation/abuse, a number of studies have clearly shown AC grey matter loss in people experiencing stressful life events and cumulative life adversities with no psychiatric diagnosis (Ansell et al, 2012;Ganzel et al, 2008;Papagni et al, 2011), as well as in animals following exposure to stress (Cerqueira et al, 2005;Kassem et al, 2013).…”

Section: Discussionmentioning

confidence: 99%

Lower anterior cingulate volume in seriously violent men with antisocial personality disorder or schizophrenia and a history of childhood abuse

Kumari

Uddin

Premkumar

et al. 2013

Aust N Z J Psychiatry

View full text Add to dashboard Cite

Objective: Antisocial personality disorder (ASPD) and schizophrenia, as well as childhood abuse, are associated with violent behaviour and show marked volumetric reduction in the anterior cingulate (AC), a brain region implicated in regulation of violence through its involvement in decision making, empathy, impulse control, and emotion regulation. The present study examined, for the first time to the authors' knowledge, the grey matter volume of the AC in relation to seriously violent behaviour and childhood psychosocial deprivation (including physical and sexual abuse) in the context of a mental disorder (schizophrenia or ASPD).Methods: Fifty-seven men [14 with ASPD and a history of serious violence; 13 with schizophrenia and a history of serious violence (VSZ); 15 with schizophrenia without a violence history (SZ); 15 nonviolent healthy participants] underwent whole-brain magnetic resonance imaging and were rated on the presence of physical abuse, sexual abuse, neglect, extreme poverty, foster home placement, criminal parent, severe family conflict, and broken home (collectively 'psychosocial deprivation'). Stereological volumetric ratings of the AC were examined for group differences and their association with childhood psychosocial deprivation.Results: A higher proportion of ASPD and VSZ patients had suffered psychosocial deprivation as children, in particular severe physical abuse, relative to SZ patients and healthy participants. ASPD and VSZ, but not SZ, patients had significantly lower AC volume relative to healthy participants. AC volumes correlated negatively with (total) psychosocial deprivation as well as physical and sexual abuse ratings. Group differences in AC volume became nonsignificant when psychosocial deprivation ratings were covaried for. Conclusions:Violent mentally disordered individuals with ASPD or schizophrenia suffer from a significant AC volume loss and this deficit, at least in part, is explained by their histories of stressful childhood experiences. Current and future therapies aiming to reduce violence in such populations would benefit by attending to biological (and other) correlates of childhood abuse.

show abstract

“…Although this interval was included as a covariate in the statistical analyses, this may have impacted the MRI findings. Finally, we did not collect data to assess pre-injury exposure to adverse life events (subjective chronic stress and cumulative life events) that may influence the volume in the orbitofrontal cortex, insula, and anterior and subgenual cingulate regions [46].…”

Section: Discussionmentioning

confidence: 99%

Longitudinal changes in brain morphology from 4 weeks to 12 months after mild traumatic brain injury: Associations with cognitive functions and clinical variables

et al. 2017

View full text Add to dashboard Cite

Objective: To investigate longitudinal changes in cortical and subcortical volumes in patients with mild traumatic brain injury (MTBI) and to evaluate whether such changes were associated with self-reported post-concussive symptoms, global functional outcomes and neuropsychological functioning.Methods: This was a prospective, longitudinal cohort study of patients with complicated (i.e., presence of intracranial abnormalities on the day-of-injury CT) and uncomplicated MTBI (i.e., absence of intracranial abnormalities). MRI was performed at approximately 4 weeks and 12 months after injury. We utilized a 3T MRI-system (Signa HDxt, GE Medical Systems, Milwaukee, WI, USA), cortical reconstruction and volumetric segmentation by FreeSurfer software. We included 33 patients with uncomplicated and 29 with complicated MTBI, aged 16-65 years.Results: 12 months after MTBI, significant within-group volume reductions were detected in the left accumbens area and right caudate nucleus for both patients groups, but no significant differences between groups were revealed. No associations between volumetric variables and post-concussive symptoms or global functioning were found. The left temporal thickness was significantly associated with executive functioning. Conclusion: Structural subcortical alterations occur after complicated and uncomplicatedMTBIs but these findings were not associated with symptoms burden or functional outcomes.Nonetheless, worse executive functioning was found in patients with shrinkage of the left temporal lobe.

show abstract

Cumulative Adversity and Smaller Gray Matter Volume in Medial Prefrontal, Anterior Cingulate, and Insula Regions

Cited by 301 publications

References 73 publications

Association of Depressive Symptoms with Hippocampal Volume in 1936 Adults

Association of Depressive Symptoms with Hippocampal Volume in 1936 Adults

Lower anterior cingulate volume in seriously violent men with antisocial personality disorder or schizophrenia and a history of childhood abuse

Longitudinal changes in brain morphology from 4 weeks to 12 months after mild traumatic brain injury: Associations with cognitive functions and clinical variables

Contact Info

Product

Resources

About