1992
DOI: 10.1007/bf03008228
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Cumulation and reversal with prolonged infusions of atracurium and vecuronium

Abstract: A randomized, double-blind study was undertaken to compare the tendencies for cumulation, and reversal characteristics of atracurium (A TR ) and vecuronium (VEC ) when administered by continuous in fusion for

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Cited by 23 publications
(16 citation statements)
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“…10 In that trial, maintenance requirements of atracurium were unaltered during a similar period of infusion. On the other hand, infusions of vecuronium had to be decreased by more than 50% over two hours to prevent progressive deepening of the level of neuromuscular block.…”
Section: Discussionmentioning
confidence: 92%
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“…10 In that trial, maintenance requirements of atracurium were unaltered during a similar period of infusion. On the other hand, infusions of vecuronium had to be decreased by more than 50% over two hours to prevent progressive deepening of the level of neuromuscular block.…”
Section: Discussionmentioning
confidence: 92%
“…10 In contrast, infusion requirements of atracurium (when potency-adjusted), remain constant for the same level of block. This observation implies absence of cumulation with atracurium, due to the much shorter elimination half-life of this drug (t 1/2 ß=20-25 min vs 60-70 min for vecuronium).…”
Section: Reports Of Investigationmentioning
confidence: 99%
“…As a result, the infusion rate required for constant effect is expected to decrease with time, as was found in several studies. [2][3] For example, in Martineau et al . 2 the infusion requirements of vecuronium decreased by almost half over a two-hour period, from 1 to 0.5 µg·kg…”
mentioning
confidence: 99%
“…[2][3] For example, in Martineau et al . 2 the infusion requirements of vecuronium decreased by almost half over a two-hour period, from 1 to 0.5 µg·kg…”
mentioning
confidence: 99%
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