Cultures of ovarian surface epithelium from women with and without a hereditary predisposition to develop female adnexal carcinoma

Piek, Jurgen M.J.; Dorsman, Josephine C.; Шварц, Анна; Ansink, Anca C.; Massuger, Leon F.A.G.; Scholten, Piet C.; Diest, Paul J. van; Dijkstra, Jan C; Weegenaar, Jitske; Kenemans, P.; Verheijen, René H.M.

doi:10.1016/j.ygyno.2003.11.022

Cited by 9 publications

(2 citation statements)

References 45 publications

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“…Most ovarian cancers arise from the surface epithelium (Piek et al 2004 ) yet the biological mechanism behind this transformation is not precisely understood. The theory of incessant ovulation attributes repeated disruption of the ovarian epithelium that leads to malignant transformation of the epithelial cells (Fathalla 1971 ; Booth et al 1989 ).…”

Section: Biology Of Epithelial Ovarian Cancermentioning

confidence: 99%

Histone deacetylases as new therapy targets for platinum-resistant epithelial ovarian cancer

Pchejetski

Alfraidi

Sacco

et al. 2015

J Cancer Res Clin Oncol

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IntroductionIn developed countries, ovarian cancer is the fourth most common cancer in women. Due to the non-specific symptomatology associated with the disease many patients with ovarian cancer are diagnosed late, which leads to significantly poorer prognosis. Apart from surgery and radiotherapy, a substantial number of ovarian cancer patients will undergo chemotherapy and platinum based agents are the mainstream first-line therapy for this disease. Despite the initial efficacy of these therapies, many women relapse; therefore, strategies for second-line therapies are required. Regulation of DNA transcription is crucial for tumour progression, metastasis and chemoresistance which offers potential for novel drug targets.MethodsWe have reviewed the existing literature on the role of histone deacetylases, nuclear enzymes regulating gene transcription.Results and conclusionAnalysis of available data suggests that a signifant proportion of drug resistance stems from abberant gene expression, therefore HDAC inhibitors are amongst the most promising therapeutic targets for cancer treatment. Together with genetic testing, they may have a potential to serve as base for patient-adapted therapies.

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Section: Biology Of Epithelial Ovarian Cancermentioning

confidence: 99%

Histone deacetylases as new therapy targets for platinum-resistant epithelial ovarian cancer

Pchejetski

Alfraidi

Sacco

et al. 2015

J Cancer Res Clin Oncol

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“…It is recently accepted that aggressive ovarian tumors originate from ovarian stem cells (OSCs), which start to proliferate intensively without control (Jiang et al, 2003; Piek et al, 2004; Bapat et al, 2005; Rosen et al, 2005). More than 80% of ovarian tumors originate from OSE.…”

Section: Introductionmentioning

confidence: 99%

Putative stem cells with an embryonic character isolated from the ovarian surface epithelium of women with no naturally present follicles and oocytes

et al. 2008

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BRCA1 and p53 protein expression in cultured ovarian surface epithelial cells derived from women with and without a BRCA1 germline mutation

Piek

Dorsman

Massuger³

et al. 2006

Arch Gynecol Obstet

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Our study indicates differences in the expression of p53, but not in the expression of BRCA1 between POSE and NPOSE. In addition, our findings do suggest the absence of losses of the wild type BRCA1 and p53 genes in the studied OSE cultures. This indicates that losses in these genes cannot account for observed differences in phenotypical traits between POSE and NPOSE, but that differences in levels of p53 might contribute.

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Cultures of ovarian surface epithelium from women with and without a hereditary predisposition to develop female adnexal carcinoma

Cited by 9 publications

References 45 publications

Histone deacetylases as new therapy targets for platinum-resistant epithelial ovarian cancer

Histone deacetylases as new therapy targets for platinum-resistant epithelial ovarian cancer

Putative stem cells with an embryonic character isolated from the ovarian surface epithelium of women with no naturally present follicles and oocytes

BRCA1 and p53 protein expression in cultured ovarian surface epithelial cells derived from women with and without a BRCA1 germline mutation

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