Cultured skin as a ‘smart material’ for healing wounds: experience in venous ulcers

Sabolinski, Michael L.; Alvarez, Oscar M.; Auletta, Michael J.; Mulder, Gerit; Parenteau, Nancy L.

doi:10.1016/0142-9612(96)85569-4

Cited by 215 publications

(108 citation statements)

References 25 publications

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“…These trials have included the use of growth factors that appear to be responsible for basic cellular communication in wound healing and the grafting of skin grown in the laboratory. 19,[26][27][28][29] These treatments are more expensive than treatment with a limb-compression bandage. Furthermore, very few of these therapies have thus far been proven to be more successful than limbcompression therapy in experimental trials.…”

Section: Discussionmentioning

confidence: 99%

Risk Factors Associated With the Failure of a Venous Leg Ulcer to Heal

Margolis

Berlin²,

Strom³

1999

Arch Dermatol

203

196

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Background: Venous leg ulcers afflict a significant portion of the population. The most popular form of therapy for venous leg ulcers is a compression bandage (eg, Unna boot), a therapy that is frequently unsuccessful.Objective: To describe risk factors associated with the failure of a wound to heal when treated with a limbcompression bandage for 24 weeks.Design: A retrospective cohort study.Setting: Single-center outpatient specialty clinic at an academic medical center.Participants: Two hundred sixty consecutive patients with chronic venous leg ulcers. Main Outcome Measure:The magnitude of the effect of a given risk factor on the probability that a wound will heal within 24 weeks of care.Results: Based on an assessment of leg wounds during initial office visits, we observed that the failure of a wound to heal within 24 weeks was significantly associated with larger wound area, measured in square centimeters (odds ratio [OR], 1.19; 95% confidence interval [CI], 1.11-1.27), duration of the wound in months (OR, 1.09; 95% CI, 1.04-1.16), history of venous ligation or venous stripping (OR, 4.58; 95% CI, 1.84-11.36), history of hip or knee replacement surgery (OR, 3.52; 95% CI, 1.12-11.08), ankle brachial index of less than 0.80 (OR, 3.52; 95% CI, 1.12-11.08), and the presence of fibrin on more than 50% of the wound surface (OR, 3.42; 95% CI,.Conclusions: Several risk factors are associated with the failure of a patient's venous leg ulcer to heal while using limb-compression therapy. It is prudent to consider these factors when referring a patient to a wound care subspecialists or for alternative therapies.

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Section: Discussionmentioning

confidence: 99%

Risk Factors Associated With the Failure of a Venous Leg Ulcer to Heal

Margolis

Berlin²,

Strom³

1999

Arch Dermatol

203

196

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“…Conversely, a living cellular construct is not integrated into the surrounding tissues, but rather, it modulates the healing activity of the underlying and adjacent tissue. It is postulated that the supply of live fibroblasts and keratinocytes improves the wound environment through growth factor interactions, matrix deposition and degradation, wound coverage, and a provision of responsive cells, leading to therapeutic functions (Sabolinski et al, 1996).…”

Section: Discussionmentioning

confidence: 99%

“…DNA of allogeneic fibroblasts and keratinocytes placed over wounds was no longer present after 6 wks of healing (Griffiths et al, 2004). It is postulated that the population of live fibroblasts and keratinocytes improves the wound environment through growth factor interactions, matrix deposition and degradation, wound coverage, and a provision of responsive cells, leading to a clinically beneficial outcome (Sabolinski et al, 1996). The purpose of this study was to investigate the expression of angiogenic biomarkers expressed during oral wound repair using living cellular constructs to regenerate soft tissue.…”

Section: Introductionmentioning

confidence: 99%

Angiogenic Biomarkers and Healing of Living Cellular Constructs

et al. 2011

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“…Given bone tissue's ability to adapt its mass and morphology to functional demands, its ability to repair itself without leaving a scar, and its capacity to rapidly mobilize mineral stores on metabolic demand, it is in fact the ultimate "smart" material [43] and a dynamic example of "form follows function" in biological systems [45]. Considering the ever-growing number of patients who suffer from devastating disorders of the skeleton and the ever-increasing opportunities inherent in the post-genomics era to treat diseases and injuries to bone [44], it is critical for both the physician and the scientist to more fully understand the biology of bone and how its ability to form and resorb tissue ultimately orchestrates the structural and metabolic successes of the skeleton.…”

Section: Introductionmentioning

confidence: 99%

Biology of bone and how it orchestrates the form and function of the skeleton

Sommerfeldt

Rubin

2001

European Spine Journal

163

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IntroductionThe skeleton's principal role as a structure has predisposed bone to the unfortunate reputation of being an inert and static material. Given bone tissue's ability to adapt its mass and morphology to functional demands, its ability to repair itself without leaving a scar, and its capacity to rapidly mobilize mineral stores on metabolic demand, it is in fact the ultimate "smart" material [43] and a dynamic example of "form follows function" in biological systems [45]. Considering the ever-growing number of patients who suffer from devastating disorders of the skeleton and the ever-increasing opportunities inherent in the post-genomics era to treat diseases and injuries to bone [44], it is critical for both the physician and the scientist to more fully understand the biology of bone and how its ability to form and resorb tissue ultimately orchestrates the structural and metabolic successes of the skeleton. CellsThree distinctly different cell types can be found within bone: the matrix-producing osteoblast, the tissue-resorbing osteoclast, and the osteocyte, which accounts for 90% of all cells in the adult skeleton. Osteocytes can be viewed as highly specialized and fully differentiated osteoblasts; Abstract The principal role of the skeleton is to provide structural support for the body. While the skeleton also serves as the body's mineral reservoir, the mineralized structure is the very basis of posture, opposes muscular contraction resulting in motion, withstands functional load bearing, and protects internal organs. Although the mass and morphology of the skeleton is defined, to some extent, by genetic determinants, it is the tissue's ability to remodel -the local resorption and formation of bone -which is responsible for achieving this intricate balance between competing responsibilities. The aim of this review is to address bone's form-function relationship, beginning with extensive research in the musculoskeletal disciplines, and focusing on several recent cellular and molecular discoveries which help understand the complex interdependence of bone cells, growth factors, physical stimuli, metabolic demands, and structural responsibilities. With a clinical and spine-oriented audience in mind, the principles of bone cell and molecular biology and physiology are presented, and an attempt has been made to incorporate epidemiologic data and therapeutic implications. Bone research remains interdisciplinary by nature, and a deeper understanding of bone biology will ultimately lead to advances in the treatment of diseases and injuries to bone itself.

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Cultured skin as a ‘smart material’ for healing wounds: experience in venous ulcers

Cited by 215 publications

References 25 publications

Risk Factors Associated With the Failure of a Venous Leg Ulcer to Heal

Risk Factors Associated With the Failure of a Venous Leg Ulcer to Heal

Angiogenic Biomarkers and Healing of Living Cellular Constructs

Biology of bone and how it orchestrates the form and function of the skeleton

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