Culture, serotonin receptor polymorphism and locus of attention

Kim, Hyoung-Soo; Sherman, David K.; Taylor, Shelley E.; Sasaki, Joni Y.; Chu, Thai Q.; Ryu, Chorong; Suh, Eunkook M.; Xu, Jianjiang

doi:10.1093/scan/nsp040

Cited by 71 publications

(38 citation statements)

References 36 publications

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“…Culture is not only constrained by genetics, but also influences the behavioral outcomes of genes (32,33), and consequently, can result in diverse psychological and behavioral expressions of genotypes. Because the functional effect of the rs57576 polymorphism at the molecular level is presently unknown, whether and how it is related to oxytocin signaling pathways is also unknown.…”

Section: Discussionmentioning

confidence: 99%

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Culture, distress, and oxytocin receptor polymorphism (OXTR) interact to influence emotional support seeking

Kim

Sherman

Sasaki

et al. 2010

Proc. Natl. Acad. Sci. U.S.A.

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Research has demonstrated that certain genotypes are expressed in different forms, depending on input from the social environment. To examine sensitivity to cultural norms regarding emotional support seeking as a type of social environment, we explored the behavioral expression of oxytocin receptor polymorphism (OXTR) rs53576, a gene previously related to socio-emotional sensitivity. Seeking emotional support in times of distress is normative in American culture but not in Korean culture. Consequently, we predicted a three-way interaction of culture, distress, and OXTR genotype on emotional support seeking. Korean and American participants (n = 274) completed assessments of psychological distress and emotional support seeking and were genotyped for OXTR. We found the predicted three-way interaction: among distressed American participants, those with the GG/AG genotypes reported seeking more emotional social support, compared with those with the AA genotype, whereas Korean participants did not differ significantly by genotype; under conditions of low distress, OXTR groups did not differ significantly in either cultural group. These findings suggest that OXTR rs53576 is sensitive to input from the social environment, specifically cultural norms regarding emotional social support seeking. These findings also indicate that psychological distress and culture are important moderators that shape behavioral outcomes associated with OXTR genotypes.genetics | social support | psychological distress | stress coping | gene-by-culture interaction

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Section: Discussionmentioning

confidence: 99%

“…33). The present findings provide further evidence to the old adage that people are products of both nurture and nature, and our approach provides a potential framework for understanding how these influences interact.…”

Section: Discussionmentioning

confidence: 99%

Culture, distress, and oxytocin receptor polymorphism (OXTR) interact to influence emotional support seeking

Kim

Sherman

Sasaki

et al. 2010

Proc. Natl. Acad. Sci. U.S.A.

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306

242

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“…Although, little research examined gene-by-environment effects in the oxytocinergic neuropathway, few studies described the interplay of OT and contextual factors, for instance, OXTR SNP variations interacted with personal distress in predicting support-seeking behavior (Kim et al, 2010). In addition to OXTR, emerging human studies have followed animal models by showing that CD38, an ectoenzyme that mediates the release of OT from hypothalamic neurons through the mobilization of calcium, has an important role in human attachment (Higashida et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

Parental Oxytocin and Early Caregiving Jointly Shape Children’s Oxytocin Response and Social Reciprocity

Feldman

Gordon

Influs

et al. 2013

Neuropsychopharmacol

543

188

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Oxytocin (OT) has an important role in bond formation and social reciprocity, and animal studies indicate that OT functioning is transferred from parent to child through patterns of parental care. Perspectives on attachment suggest that the individual's various attachment bonds are underpinned by the oxytocinergic system. However, prospective human studies that demonstrate the cross-generation transfer of OT as mediated by early caregiving and its impact on children's multiple attachments are lacking. To address these concerns, the current study included 160 mothers and fathers and their firstborn child who participated in a 3-year longitudinal study. At the first and sixth postpartum months, parents' plasma OT was assayed, parent-infant interactions were videotaped and micro-coded, and allelic variations on the OXTR(rs2254298, rs1042778) and CD38rs3796863 genes were measured. At 3 years, parents' and child's salivary OT was assessed and children's social reciprocity observed during interactions with mother, father, and their first best friend. Parents' OT levels were individually stable across the 3-year period, correlated with low-risk OXTR and CD38 alleles, and predicted child OT. Child's social reciprocity with friend was associated with child OT levels, mother's OT-related genes and hormones, and mother-child reciprocity, but not with father's genes, hormones, or behavior. A cross-generation gene-by-environment effect emerged, with low child OT levels predicted by the interaction of maternal high-risk CD38 allele and diminished maternal care in infancy. These results demonstrate individual stability in peripheral OT across several years and describe a cross-generation transfer of OT through caregiving in humans within a prospective longitudinal design. Consistent with other mammals, biobehavioral experiences within the parent-infant bond shape children's affiliative biology and social behavior across multiple attachments. Our findings bear important implications for conditions involving disruptions to maternal-infant bonding and underscore the potential for peer-based interventions.

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“…For example, gene-culture interactions have been found with an oxytocin receptor polymorphism (OXTR) (Kim et al 2010a(Kim et al , 2011, a serotonin receptor polymorphism (5-HTR1A) (Kim et al 2010b) and the dopamine D4 receptor polymorphism (DRD4) (Kitayama et al in press). Gene-environment interactions have also been found with 5-HTTLPR (Caspi et al 2003;Taylor et al 2006), DRD4 (Bakermans-Kranenburg et al 2008Sasaki et al 2013), monoamine oxidase A gene (MAOA) (Caspi et al 2002), and OXTR (Chen et al 2011), among others.…”

Section: Discussionmentioning

confidence: 99%

Culture modulates sensitivity to the disappearance of facial expressions associated with serotonin transporter polymorphism (5-HTTLPR)

et al. 2014

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The present research investigated an association between the serotonin transporter polymorphism (5-HTTLPR) and sensitivity to the disappearance of facial expressions cross-culturally and found, for the first time, that cultural norms and practices modulate the association. Participants watched both happy-to-neutral and sad-to-neutral movies and judged the point at which the emotional expressions disappeared. As predicted, the results showed that Japanese with the s/s genotype detected the disappearance of facial expressions (particularly the disappearance of smiles) with greater perceptual efficiency than did those with s/l and l/l genotypes, whereas such a tendency was not found in Americans. This suggests that people with the s/s genotype of 5-HTTLPR are more sensitive to environmental changes, but only when the change is culturally important, compared to people with the long allele. Moreover, Asian Americans' pattern was much more similar to European Americans than to Japanese, supporting the idea that the differences between cultural groups are indeed due to different cultural experiences.

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Culture, serotonin receptor polymorphism and locus of attention

Cited by 71 publications

References 36 publications

Culture, distress, and oxytocin receptor polymorphism (OXTR) interact to influence emotional support seeking

Culture, distress, and oxytocin receptor polymorphism (OXTR) interact to influence emotional support seeking

Parental Oxytocin and Early Caregiving Jointly Shape Children’s Oxytocin Response and Social Reciprocity

Culture modulates sensitivity to the disappearance of facial expressions associated with serotonin transporter polymorphism (5-HTTLPR)

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