Culture-negative neutrocytic ascites: a less severe variant of spontaneous bacterial peritonitis

Pelletier, G; Salmon, D; Ink, Olivier; Hannoun, S; Attali, P; Buffet, Catherine; Etienne, J. P.

doi:10.1016/0168-8278(90)90140-m

Cited by 62 publications

(42 citation statements)

References 16 publications

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“…An outstanding observation of this study was that none of the microbiological data analyzed predicted SBP resolution and patient survival. Previous investigations have suggested that culture-negative SBP responds better to antibiotic therapy and is associated with lower mortality than is culture-positive SBP (13, 24). This study does not support this contention.…”

Section: Discussioncontrasting

confidence: 74%

Spontaneous bacterial peritonitis in cirrhosis: Predictive factors of infection resolution and survival in patients treated with cefotaxime

et al. 1993

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Cefotaxime is the most commonly used antibiotic for initial therapy of spontaneous bacterial peritonitis in cirrhosis. However, since the introduction of cefotaxime no study has been performed to investigate factors influencing prognosis in cirrhotic patients with this type of infection. In this study, predictive factors for infection resolution and patient survival were investigated in 213 consecutive episodes of spontaneous bacterial peritonitis in 185 cirrhotic patients. All patients were initially treated with cefotaxime. One hundred sixty-five episodes (77%) resolved with cefotaxime alone, and two more episodes (1%), initially unresponsive to cefotaxime, were cured after modification of antibiotic therapy. In a multivariate analysis (stepwise logistic regression), only 4 of 51 clinical and laboratory variables obtained at the time of diagnosis of infection were identified as independent predictors of infection resolution: band neutrophils in white blood cell count, community-acquired vs. hospital-acquired peritonitis, blood urea nitrogen level and serum aspartate aminotransferase level. No patient experienced serious adverse effects related to cefotaxime. Eighty-two patients died during hospitalization (38% mortality rate in relation to the 213 episodes of peritonitis). In the multivariate analysis, six variables were independently correlated with survival: blood urea nitrogen level, serum aspartate aminotransferase level, community-acquired vs. hospital-acquired peritonitis, age, Child-Pugh score and ileus. No microbiological data had predictive value for infection resolution or survival.(ABSTRACT TRUNCATED AT 250 WORDS)

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Section: Discussioncontrasting

confidence: 74%

Spontaneous bacterial peritonitis in cirrhosis: Predictive factors of infection resolution and survival in patients treated with cefotaxime

et al. 1993

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“…Overall, the sensitivity of bacteriological culture was lower in their study (30%) compared to our study (47%) and the average sensitivity reported in the literature (,40%) [1,15,16]. Of note, culture positive SBP has been associated with an increased mortality [17]. Another small case control study [18] reported a preventive effect of rifaximin on SBP in a cohort of patients with decompensated cirrhosis.…”

Section: Discussioncontrasting

confidence: 47%

Impact of rifaximin on the frequency and characteristics of spontaneous bacterial peritonitis in patients with liver cirrhosis and ascites

Lutz¹,

Parčina²,

Bekeredjian‐Ding³

et al. 2014

Z Gastroenterol

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“…The rate of culture-positive ascitic fluid infection in our study was 21%, less than in the previous reports where it ranged from 23 to 70% [23][24][25][26]. The probable explanation for this low rate of ascitic fluid bacterial growth in our study was the method of culturing ascitic fluid.…”

Section: Discussioncontrasting

confidence: 83%

Potential Preventability of Spontaneous Bacterial Peritonitis

et al. 2011

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Culture-negative neutrocytic ascites: a less severe variant of spontaneous bacterial peritonitis

Cited by 62 publications

References 16 publications

Spontaneous bacterial peritonitis in cirrhosis: Predictive factors of infection resolution and survival in patients treated with cefotaxime

Spontaneous bacterial peritonitis in cirrhosis: Predictive factors of infection resolution and survival in patients treated with cefotaxime

Impact of rifaximin on the frequency and characteristics of spontaneous bacterial peritonitis in patients with liver cirrhosis and ascites

Potential Preventability of Spontaneous Bacterial Peritonitis

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