Culture negative endocarditis

Excellent Prognosis of Culture Negative Endocarditis in Hemodialysis Patients: A Case Series

“…[4,5] Repeated puncture, defective vessel wall, and immune dysregulation all contribute to the increased incidence of bacteremia in dialysis patients. [14,15] The high risk of CNE in chronic hemodialysis patients may be due to exposure to prior antibiotics, short and transient bacteremia, slow and fastidious growing microorganisms, inadequate or insufficient microbiologic diagnostic techniques, or the lack of consensus of case definition in dialysis population.…”

“…[14,15] The high risk of CNE in chronic hemodialysis patients may be due to exposure to prior antibiotics, short and transient bacteremia, slow and fastidious growing microorganisms, inadequate or insufficient microbiologic diagnostic techniques, or the lack of consensus of case definition in dialysis population. [4,5,8] Most authors recommend penicillin or ampicillin combined with gentamicin for treating CNE patients. This regimen is effective against enterococci and most HACEK organisms, but the optimal regimen in a dialysis population is still unknown.…”

“…[21] Furthermore, mortality is increased in patients receiving delayed treatment and in those still febrile after one week of therapy. [5,12,22] The outcome of CNE in a dialysis population is unknown. All five patients in our series survived.…”

“…[1,2] Patients with CNE demonstrate increased morbidity and mortality compared to those with culturepositive infective endocarditis. [3,4] The uremia and end stage renal disease (ESRD) population is a high risk patient group in CNE, [5][6][7] but the clinical course and outcome of CNE in these patients is unclear. This clinical study of five chronic hemodialysis patients with CNE revealed an excellent outcome in all patients.…”

Legionella native valve endocarditis case report and review of literature

“…Streptococcus and Staphylococcus species are the cause for endocarditis in about 80%, another 10% are caused by Enterococcus species or bacteria of the HACEK-group. According to Barnes et al culture negative endocarditis accounts for 2.5 to 31% of all cases [3]. Negative blood cultures often result from previous antimicrobial therapy or fastidious bacteria (mostly Coxiella burnetti, Bartonella spp.…”