Cultural and biological determinants of lipoprotein concentrations

Rao, D. C.; Morton, N. E.; Gulbrandsen, C. L.; Rhoads, George G.; Kagan, Abraham; Yee, Shirley J.

doi:10.1111/j.1469-1809.1979.tb00680.x

Cited by 100 publications

(49 citation statements)

References 11 publications

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“…The cultural inherit ance, although statistically highly signifi cant, explains only a relatively small per cent of the variation of TC and LDL-C (3-5%) and accounts for about twice as much of the variance of HDL-C, HDL-C/TC ratio and TG. Our estimates of the genetic (h2) and cultural (c2) fractions of lipid variability are in fair agreement with those reported for the collaborative LRC [Namboodiri et al, 1985]; the Honolulu Heart Study, [ Rao et al, 1979], and for the Cincinnati LRC [Raw et al, 1982], all us ing a similar path model. Similar findings were reported from other studies utilizing alternative methodologies [ Weinberg et al, 1982;Beaty et al, 1983].…”

Section: Discussionsupporting

confidence: 76%

Biological and Environmental Sources of Variation in Plasma Lipids and Lipoproteins: The Jerusalem Lipid Research Clinic

1986

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We have previously described a general pattern of homogeneity in genetic and cultural determinants of blood lipids and lipoproteins among the major origin groups in the Israeli population. This paper reports on these determinants of total plasma cholesterol (TC), triglyceride (TG), low- and high-density lipoprotein cholesterol (LDL-C, HDL-C), and of the HDL-C/TC ratio, estimated from the total sample of 4,000 families whose members were examined in the Jerusalem Lipid Research Clinic. Both genetic (h²) and cultural (c²) components of inheritance were significant for all lipid variables. Under the most parsimonious model genetic heritability (h²) ranges from 0.45 for LDL-C, 0.47 for HDL-C to 0.64 for HDL-C/TC ratio. Cultural heritability (c²) was 0.03 for LDL-C, 0.04 for TC, 0.05 for TG and 0.07 for HDL-C and HDL-C/TC ratio. Within this population, as in others, genetic factors appear to be the major determinants of lipid variation, suggesting relative homogeneity of environmental correlates of plasma lipids.

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Section: Discussionsupporting

confidence: 76%

Biological and Environmental Sources of Variation in Plasma Lipids and Lipoproteins: The Jerusalem Lipid Research Clinic

1986

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“…Pairwise estimators were used for parent-offspring correlations and the ANOVA method for sibling correlations except where indicated. The Framingham Offspring Study 14 and the Honolulu Heart Study 36 have the largest number of pairs compared with other studies. In the former, where adjustment for varying concomitant factors was reported, the results were similar to the LRC study in that the correlations were not altered to an appreciable degree, although there was a slight weakening trend in the association with adjustments.…”

Section: Discussionmentioning

confidence: 97%

Family aggregation of high density lipoprotein cholesterol. Collaborative lipid research clinics program family study.

Namboodiri¹,

Green²,

Kaplan³

et al. 1983

Arteriosclerosis

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High density lipoprotein cholesterol data on a population-based random sample of 858 white and 72 black probands and their 3935 white and 205 black relatives were collected from nine North American clinics using a common protocol and standardized methodology. Familial associations were examined within clinics for whites and pooled across clinics for blacks. The influence of covariates and varying family size on correlations was examined using several sets of transformed and adjusted values and a variety of weighting schemes.Parent-offspring and sibling correlations were significant in most cases, but spouse correlations were not, suggesting a stronger influence of shared genes than shared environment on high density lipoprotein cholesterol. Adjustment for covariates tended to weaken the correlations, but the effect of variable family size was imperceptible. Although pairs involving pediatric offspring or siblings tended to show higher correlation than their adult counterparts, the differences were not significant. All correlations except father-daughter and brother-brother were homogeneous across clinics in whites. There was no asymmetry in parent-child correlations by the sex of the offspring, but the pooled mother-child correlation was significantly higher than father-child values, suggesting a possible maternal influence on high density lipoprotein cholesterol. No heterogeneity in correlations in high density lipoprotein cholesterol was detected between blacks and whites except for mother-son pairs.

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“…[1][2][3][4][5][6][7][8][9][10][11][12][13][14] We therefore evaluated a large group of patients with aneurysmal coronary disease from the registry data of the multiinstitutional Coronary Artery Surgery Study (CASS), sponsored by the National Institutes of Health (NIH). 5 We examined the clinical and historical features and the natural history of coronary aneurysmal disease to determine whether it represents a distinct clinical entity or a variant of coronary atherosclerotic disease.…”

Section: Discussionmentioning

confidence: 99%

Total cholesterol and lipoproteins in school children: prediction of coronary heart disease in adult relatives.

et al. 1983

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Robinson BF: Mode of action of nitroglycerin in angina pectoris.Correlation between haemodynamic effects dunng exercise and prevention of pain. Br Heart J 30: 295, 1968 4. Parker JO, West PO, DiGeorgi S: The effects of nitroglycerin on coronary blood flow and the hemodynamic response to exercise in coronary artery disease. Am J Cardiol 27: 59, 1971 5. Detry JR, Bruce RA: Effect of nitroglycerin on "maximal" oxygen intake and exercise electrocardiogram in coronary heart disease. ATHEROSCLEROSIS underlies most coronary heart disease (CHD), ' but is difficult to study because a large proportion of the population with affected arteries has no easily detected manifestation of the disease.

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Cultural and biological determinants of lipoprotein concentrations

Cited by 100 publications

References 11 publications

Biological and Environmental Sources of Variation in Plasma Lipids and Lipoproteins: The Jerusalem Lipid Research Clinic

Biological and Environmental Sources of Variation in Plasma Lipids and Lipoproteins: The Jerusalem Lipid Research Clinic

Family aggregation of high density lipoprotein cholesterol. Collaborative lipid research clinics program family study.

Total cholesterol and lipoproteins in school children: prediction of coronary heart disease in adult relatives.

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