Cultivation of bovine C-type leukemia virus, its transmission to calves and the development of leukemia as determined by hematological, electron microscopical and immunodiffusion test

Schmidt, F.-W.; Mitscherlich, E.; Lima, Emerson Quintino de; Milczewski, K.E.v.; Lembke, A.

doi:10.1016/0378-1135(76)90025-0

Cited by 3 publications

(1 citation statement)

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“…These results are corroborated by experimental studies in which a serologic response following BLV inoculation was consistent Schmidt et al, 1976;Van Der Maaten and Miller, 1978b;Van Der Maaten et al . , 1981a) and persistent (Miller and Van Der Maaten, 1976b) .…”

Section: Comparisons Of Several Serologic Tests Have Demonstratedsupporting

confidence: 75%

Epidemiology of natural transmission of bovine leukemia virus infection / by Mark Cy Thurmond.

Thurmond¹

1982

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A 27-month study examined 473 dairy cattle for associations between bovine leukemia virus (BLV) infection and host and environmental factors. Cattle sera were tested at monthly intervals for BLV antibodies by agar-gel immunodiffusion using the glycoprotein-51 antigen. A model of BLV colostral antibody decay in 130 calves predicted infection in calves less than six months of age and estimated antibody half-life to be 27.1 ±1.2 days. Colostral antibody decay did not differ between BLV-infected and noninfected calves for slope (p = 0.45) or intercept (p = 0.43). By 95 days of age, 50% of the calves had no detectable BLV colostral antibodies. Of 125 calves born to BLV-infected cows and followed for at least four months, eight (6.4%) had precolostral BLV antibodies, as determined by radioimmunoassay using the glycoprotein-51 antigen-In utero infection with BLV was not associated with dam age (p = 0.86), dam parity (p = 0.83), breed (p = 0.66), sex (p = 0.11), or stage of gestation in which the dam was infected (p=0.50). Calves infected in utero did not pose an increased risk of infection to calves penned next to them (p = 0.61). Prevalence rates of infection were 9%, 16%, and 63% at 6, 16, and 27 months of age, respectively. Age-specific rates of infection were not associated with dam age (p = 0.79), dam parity (p=0.75), dam BLV-status (p = 0.46), breed (p = 0.86), or BLV-status of colostrum consumed (p=0.50). An algorithm was described which allocated probabilities of infection to locations occupied by an animal prior to detection of infection. Small calf pastures were associated with less infection than was the calf barn (p< 0.05). No less infection was associated with individual outdoor calf pens compared to contiguous indoor pens (p>0.05). Risk of infection associated with the dry herd was five times that for heifer pastures (p< 0.0001) and accounted 24 infections per 100 heifers per 100 days at risk. Vaccination for infectious diseases was not associated with increased BLV infection (p=0.33). Infection rates were not associated with month of birth (p = 0.24) or with season of potential arthropod vectors (p = 0.20). Heifer infection was likely to occur in late v/inter or spring (p =. 01). Interacting Computing (MUSIC) version 4.1, 197 8.

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Section: Comparisons Of Several Serologic Tests Have Demonstratedsupporting

confidence: 75%