Cultivated meat as a tool for fighting antimicrobial resistance

McNamara, E. R.; Bomkamp, Claire

doi:10.1038/s43016-022-00602-y

Cited by 13 publications

(5 citation statements)

References 17 publications

(40 reference statements)

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“…From the engineering and agro-industrial point of view, removing pharmaceutics and antibiotic resistance genes (ARGs) from water, soil, animal feed, and manure would greatly help reduce antibiotic resistance. This feature can be achieved by combining metalbased filtering systems [62,63], biological and biotechnological agents [64,65], and better maintenance and management [66,67]; a remarkable, somewhat different example in the field is brought up by the use of cultivated meat, which not only drastically reduces CO 2 , biological, and chemical waste with respect to farms but also almost deletes the need for antibiotics [68,69].…”

Section: Polymixinsmentioning

confidence: 99%

Innovative Phospholipid Carriers: A Viable Strategy to Counteract Antimicrobial Resistance

Nicolosi,

Petronio Petronio,

Russo

et al. 2023

IJMS

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The overuse and misuse of antibiotics have led to the emergence and spread of multidrug-resistant (MDR), extensively drug-resistant (XDR), and pan-drug-resistant (PDR) bacteria strains, usually associated with poorer patient outcomes and higher costs. In order to preserve the usefulness of these life-saving drugs, it is crucial to use them appropriately, as also recommended by the WHO. Moreover, innovative, safe, and more effective approaches are being investigated, aiming to revise drug treatments to improve their pharmacokinetics and distribution and to reduce the onset of drug resistance. Globally, to reduce the burden of antimicrobial resistance (AMR), guidelines and indications have been developed over time, aimed at narrowing the use and diminishing the environmental spread of these life-saving molecules by optimizing prescriptions, dosage, and times of use, as well as investing resources into obtaining innovative formulations with better pharmacokinetics, pharmacodynamics, and therapeutic results. This has led to the development of new nano-formulations as drug delivery vehicles, characterized by unique structural properties, biocompatible natures, and targeted activities such as state-of-the-art phospholipid particles generally grouped as liposomes, virosomes, and functionalized exosomes, which represent an attractive and innovative delivery approach. Liposomes and virosomes are chemically synthesized carriers that utilize phospholipids whose nature is predetermined based on their use, with a long track record as drug delivery systems. Exosomes are vesicles naturally released by cells, which utilize the lipids present in their cellular membranes only, and therefore, are highly biocompatible, with investigations as a delivery system having a more recent origin. This review will summarize the state of the art on microvesicle research, liposomes, virosomes, and exosomes, as useful and effective tools to tackle the threat of antibiotic resistance.

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Section: Polymixinsmentioning

confidence: 99%

Innovative Phospholipid Carriers: A Viable Strategy to Counteract Antimicrobial Resistance

Nicolosi,

Petronio Petronio,

Russo

et al. 2023

IJMS

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“…Cellular agriculture offers numerous advantages for sustainable and ethical food production. The proposed approaches reduce environmental impact when scaled up, primarily by requiring fewer resources and emitting fewer greenhouse gases (Soice and Johnston, 2021), reduce foodborne pathogens risks and improve animal welfare (McNamara and Bomkamp, 2022).…”

Section: Introductionmentioning

confidence: 99%

Decellularized banana leaves: eco-friendly scaffolds for cell-based seafood

Banavar,

Sarkarat,

Amirvaresi

et al. 2024

Front. Sustain. Food Syst.

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Cellular agriculture holds the potential to address sustainability, food security, and agricultural resilience. Within the cell-based meat supply chain, one of the key steps is developing sustainable scaffolding. In this study, we evaluated the impact of decellularized banana leaves, various coating materials including soy protein and gelatine, and different cell seeding strategies on cell viability, cell growth, cell alignment, and the response of the materials to thermal processing. Kinetics of the quality degradation of the scaffolds with and without cells were determined through kinetics equations. The efficiency of decellularization was verified through DNA quantification, which decreased from 445 ng/mg in fresh banana leaves to non-detectable levels in the decellularized samples. The alignment of cells on gelatin-coated samples was the highest among the samples, with a dominant orientation of 65.8°, compared to soy-coated and uncoated samples, with dominant orientations of 9.2° and −6.3°, respectively. The kinetics of shrinkage indicated that coating with soy and the presence of cells increased the activation energy due to the higher energy required for protein denaturation. The kinetics of area changes in plain scaffolds without cells followed a first-order pattern, while with seeded cells a second-order pattern was followed. Overall, the results showed that decellularized banana leaves provide sustainable scaffoldings for cellular agriculture applications. In addition, soy coating provided many benefits for decellularized samples by supporting cell adhesion and cell proliferation.

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“…A proposed approach to remedy these challenges is to use CM (also referred to as cultivated meat, cell-cultured meat, or in vitro meat) – a strategy proposed by Winston Churchill ( 12 ) involving the in vitro culturing of specific groups of animal cells for consumption by humans, thereby addressing animal welfare concerns ( 13 ). CM has been presented as a better alternative to conventional meat in terms of environmental impacts ( 14 – 16 ) and reducing the prevalence of antimicrobial resistance ( 17 ). Since the unveiling of the first CM burger in 2013 by Mark Post, over 100 CM production companies have been formed and are racing to bring CM to market across the globe ( 18 ).…”

Section: Introductionmentioning

confidence: 99%

Nutrient recovery in cultured meat systems: Impacts on cost and sustainability metrics

et al. 2023

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A growing global meat demand requires a decrease in the environmental impacts of meat production. Cultured meat (CM) can potentially address multiple challenges facing animal agriculture, including those related to animal welfare and environmental impacts, but existing cost analyses suggest it is hard for CM to match the relatively low costs of conventionally produced meat. This study analyzes literature reports to contextualize CM’s protein and calorie use efficiencies, comparing CM to animal meat products’ feed conversion ratios, areal productivities, and nitrogen management. Our analyses show that CM has greater protein and energy areal productivities than conventional meat products, and that waste nitrogen from spent media is critical to CM surpassing the nitrogen use efficiency of meat produced in swine and broiler land-applied manure systems. The CM nutrient management costs, arising from wastewater treatment and land application, are estimated to be more expensive than in conventional meat production. Overall, this study demonstrates that nitrogen management will be a key aspect of sustainability in CM production, as it is in conventional meat systems.

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Cultivated meat as a tool for fighting antimicrobial resistance

Abstract: Antibiotic use in livestock and aquaculture production is driving resistance to medically important antibiotics. Producing meat through alternative methods, such as cultivated meat, offers an opportunity to decouple antibiotics from meat.

Cited by 13 publications

References 17 publications

Innovative Phospholipid Carriers: A Viable Strategy to Counteract Antimicrobial Resistance

Innovative Phospholipid Carriers: A Viable Strategy to Counteract Antimicrobial Resistance

Decellularized banana leaves: eco-friendly scaffolds for cell-based seafood

Nutrient recovery in cultured meat systems: Impacts on cost and sustainability metrics

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