Cullin7 promotes epithelial‑mesenchymal transition of esophageal carcinoma via the ERK‑SNAI2 signaling pathway

Tian, Pingï¿1⁄2; Liu, Dandanï¿1⁄2; Sun, Luyiï¿1⁄2; Sun, Hui

doi:10.3892/mmr.2018.8503

Cited by 7 publications

(7 citation statements)

References 22 publications

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“…CUL 7, Culin 7, is a component of an E 3 ubiquitin − proteinligase complex and interacts with p 53, CUL 9 and FBXW 8, and is reported to be an antiapoptotic oncogene 47 . CUL 7 has been associated with various cancer types, but its promotion of epithelial-mesenchymal transition in metastasis and its regulation of ERK − SNAI 2 signalling affecting the expression of cell adhesion proteins, E − cadherins , fibronectin , N − cadherin and vimentin in cancer is well studied 48 . CUL 7 inhibits apoptosis in lung cancer through inhibition of p 53 which regulates c − MYC cell cycle progression 47 .…”

Section: Discussionmentioning

confidence: 99%

Identification of key regulators in prostate cancer from gene expression datasets of patients

Mangangcha

Malik

Küçük

et al. 2019

Sci Rep

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Identification of key regulators and regulatory pathways is an important step in the discovery of genes involved in cancer. Here, we propose a method to identify key regulators in prostate cancer (PCa) from a network constructed from gene expression datasets of PCa patients. Overexpressed genes were identified using BioXpress, having a mutational status according to COSMIC, followed by the construction of PCa Interactome network using the curated genes. The topological parameters of the network exhibited power law nature indicating hierarchical scale-free properties and five levels of organization. Highest degree hubs (k ≥ 65) were selected from the PCa network, traced, and 19 of them was identified as novel key regulators, as they participated at all network levels serving as backbone. Of the 19 hubs, some have been reported in literature to be associated with PCa and other cancers. Based on participation coefficient values most of these are connector or kinless hubs suggesting significant roles in modular linkage. The observation of non-monotonicity in the rich club formation suggested the importance of intermediate hubs in network integration, and they may play crucial roles in network stabilization. The network was self-organized as evident from fractal nature in topological parameters of it and lacked a central control mechanism.

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Section: Discussionmentioning

confidence: 99%

Identification of key regulators in prostate cancer from gene expression datasets of patients

Mangangcha

Malik

Küçük

et al. 2019

Sci Rep

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“…A study in esophageal carcinoma (EC) showed that CUL7 protein expression was significantly higher than that in normal tissues, and was positively associated with tumor invasion and metastasis. An in vitro investigation demonstrated that CUL7 promotes the EMT of EC1 cells, indicating the mechanism of EC tumor metastasis 59 . Moreover, Zhi et al identified that CUL7 was able to differentiate the metastatic and non-metastatic colon cancer samples by using a support vector machine classifier 60 .…”

Section: Cul7 In Cancermentioning

confidence: 99%

“…These above studies show that CUL7 is associated with both proteolytic and non-proteolytic functional interactions. Notably, a recent study revealed that CUL7 could regulate the ERK-SNAI2 signaling pathway and promote EMT in EC 59 . However, whether CUL7 interacts with SNAI2 has not been studied.…”

Section: Cul7 Substrate Proteins In Development and Cancermentioning

confidence: 99%

The functional analysis of Cullin 7 E3 ubiquitin ligases in cancer

Shi¹,

Du²,

Peng³

et al. 2020

Oncogenesis

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Cullin (CUL) proteins have critical roles in development and cancer, however few studies on CUL7 have been reported due to its characteristic molecular structure. CUL7 forms a complex with the ROC1 ring finger protein, and only two F-box proteins Fbxw8 and Fbxw11 have been shown to bind to CUL7. Interestingly, CUL7 can interact with its substrates by forming a novel complex that is independent of these two F-box proteins. The biological implications of CUL-ring ligase 7 (CRL7) suggest that the CRL7 may not only perform a proteolytic function but may also play a non-proteolytic role. Among the existing studied CRL7-based E3 ligases, CUL7 exerts both tumor promotion and suppression in a context-dependent manner. Currently, the mechanism of CUL7 in cancer remains unclear, and no studies have addressed potential therapies targeting CUL7. Consistent with the roles of the various CRL7 adaptors exhibit, targeting CRL7 might be an effective strategy for cancer prevention and treatment. We systematically describe the recent major advances in understanding the role of the CUL7 E3 ligase in cancer and further summarize its potential use in clinical therapy.

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“…CUL7, Culin7, is a component of an E3 ubiquitin-protein ligase complex and interacts with p53, CUL9 and FBXW8, and is reported to be an antiapoptotic oncogene (59). CUL7 has been associated with various cancer types, but its promotion of epithelial-mesenchymal transition in metastasis and its regulation of ERK-SNAI2 signalling affecting the expression of cell adhesion proteins, E-cadherins, fibronectin, N-cadherin and vimentin in cancer is well studied (60). CUL7…”

mentioning

confidence: 99%

Identification of key regulators in Prostate cancer from gene expression datasets of patients

Mangangcha

Malik

Küçük

et al. 2019

Preprint

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Identification of key regulators and regulatory pathways is an important step in the discovery of genes involved in cancer. Here, we propose a method to identify key regulators in prostate cancer (PCa) from a network constructed from gene expression datasets of PCa patients.Overexpressed genes were identified using BioXpress, having a mutational status according to COSMIC, followed by the construction of PCa Interactome network using the curated genes.The topological parameters of the network exhibited power law nature indicating hierarchical scale-free properties and five levels of organization. Highest degree hubs (k≥65) were selected from the PCa network, traced, and 19 of them were identified as novel key regulators, as they participated at all network levels serving as backbone. Of the 19 hubs, some have been reported in literature to be associated with PCa and other cancers. Based on participation coefficient values most of these are connector or kinless hubs suggesting significant roles in modular linkage. The observation of non-monotonicity in the rich club formation suggested the importance of intermediate hubs in network integration, and they may play crucial roles in network stabilization. The network was self-organized as evident from fractal nature in topological parameters of it and lacked a central control mechanism.

show abstract

Cullin7 promotes epithelial‑mesenchymal transition of esophageal carcinoma via the ERK‑SNAI2 signaling pathway

Cited by 7 publications

References 22 publications

Identification of key regulators in prostate cancer from gene expression datasets of patients

Identification of key regulators in prostate cancer from gene expression datasets of patients

The functional analysis of Cullin 7 E3 ubiquitin ligases in cancer

Identification of key regulators in Prostate cancer from gene expression datasets of patients

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