CUL4B mutations impair human cortical neurogenesis through PP2A-dependent inhibition of AKT and ERK
Yanyan Ma,
Xiaolin Liu,
Min Zhou
et al.
Abstract:Mutation in CUL4B gene is one of the most common causes for X-linked intellectual disability (XLID). CUL4B is the scaffold protein in CUL4B-RING ubiquitin ligase (CRL4B) complex. While the roles of CUL4B in cancer progression and some developmental processes like adipogenesis, osteogenesis, and spermatogenesis have been studied, the mechanisms underlying the neurological disorders in patients with CUL4B mutations are poorly understood. Here, using 2D neuronal culture and cerebral organoids generated from the p… Show more
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