CuI-catalyzed synthesis of multisubstituted pyrido[1,2-a]pyrimidin-4-ones through tandem Ullmann-type C–N cross-coupling and intramolecular amidation reaction

Abstract

Starting from 2-halopyridines and ester (Z)-3-amino-3-arylacrylates, one-pot tandem syntheses of diverse pyrido[1,2-a]pyrimidin-4-ones have been established via CuI-catalyzed Ullmann-type C–N bond formation/intramolecular amidation reaction.