Objective: Accurate measurement of central blood pressure (BP) using upper arm cuff-based methods is associated with several factors, including determining the level of systolic BP (SBP) amplification. This study aimed to determine the agreement between cuff-based and invasively measured SBP amplification.Methods: Patients undergoing coronary angiography had invasive SBP amplification (brachial SBP -central SBP) measured simultaneously with cuff-based SBP amplification using a commercially available central BP device (device 1: Sphygmocor Xcel; n ¼ 171, 70% men, 60 AE 10 years) and a now superseded model of a central BP device (device 2: Uscom BPR; n ¼ 52, 83% men, 62 AE 10 years).Results: Mean difference (AE2SD, limits of agreement) between cuff-based and invasive SBP amplification was 4 mmHg (À12, R20 mmHg, P < 0.001) for device 1 and À2 mmHg (À14, R10 mmHg, P ¼ 0.10) for device 2. Both devices systematically overestimated SBP amplification at lower levels and underestimated at higher levels of invasive SBP amplification, but with stronger bias for device 1 (r ¼ À0.68 vs. r ¼ À0.52; Z ¼ 2.72; P ¼ 0.008). Concordance of cuff-based and invasive SBP amplification across quartiles of invasive SBP amplification was low, particularly in the lowest and highest quartiles. The root mean square errors from regression between cuff-based central SBP and brachial SBP were significantly lower (indicating less variability) than from invasive regression models (P < 0.001).Conclusions: Irrespective of the difference from invasive measurements, cuff-based estimates of SBP amplification showed evidence of proportional systematic bias and had less individual variability. These observations could provide insights on how to improve the performance of cuff-based central BP.