Cuevaenes C–E: Three new triene carboxylic derivatives from <i>Streptomyces</i> sp. LZ35Δ<i>gdmAI</i>

Deng, Jingjing; Chen, Lu; Li, Yaoyao; Li, Shan-Ren; Shen, Yue

doi:10.3762/bjoc.10.82

Cited by 7 publications

(5 citation statements)

References 10 publications

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“…Cuevaenes A, obtained from gdmAI -disrupted Streptomyces sp. LZ35, exhibits antibacterial activity . (−)-Eupachinin B and its enantiomer, isolated from the roots of Eupatorium chinense , possess an unusual 1,2,3,4-tetrahydrodibenzo[ b , d ]furan skeleton .…”

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confidence: 99%

Construction of Hydrodibenzo[b,d]furan Frameworks from Morita–Baylis–Hillman Carbonates of Isatins and o-Hydroxy Enones via Palladium and Brønsted Base Relay Catalysis

Chen

et al. 2021

Org. Lett.

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A cascade assembly between isatin-derived Morita−Baylis−Hillman carbonates and o-hydroxybenzylideneacetones has been developed under the relay catalysis of Pd(PPh 3 ) 4 and DBU, affording a spectrum of 1,2,3,4-tetrahydrodibenzo[b,d]furan architectures incorporating a spirooxindole motif in moderate to good yields with excellent diastereoselectivity. The fused indole analogues were similarly furnished by employing the benzylideneacetones having an o-TsNH group.Letter pubs.acs.org/OrgLett

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confidence: 99%

Construction of Hydrodibenzo[b,d]furan Frameworks from Morita–Baylis–Hillman Carbonates of Isatins and o-Hydroxy Enones via Palladium and Brønsted Base Relay Catalysis

Chen

et al. 2021

Org. Lett.

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“…The cultivated strain of Streptomyces LZ35 produces cuevaenes A and C, cuevaenes D and E, and cuevaene B. Cuevaenes A-C displayed moderate activity against Bacillus subtilis and against fungi Fusarium verticillioides, and Rhizoctonia solani [154]. Cuevaenes A, C and cuevaene B contained unusual FA (136)(137)(138), respectively.…”

Section: No Predicted Biological Activity Pa *mentioning

confidence: 99%

“…CMB-M0232 obtained from a sediment sample near Brisbane, Australia is a producer of nocardiopsins A-D [166,167]. Nocardiopsins A and C contained FA (154), and nocardiopsins B and D contained FA (155). Two polyketide metabolites, thailandamide A and thailandamide lactone with (E)-7-hydroxy-8-(4-hydroxyphenyl)-2-methyloct-4-enoic acid (156) have been isolated from gram-negative bacillus Burkholderia thailandensis [168,169].…”

Section: No Predicted Biological Activity Pa *mentioning

confidence: 99%

Microbiological Aspects of Unique, Rare, and Unusual Fatty Acids Derived from Natural Amides and Their Pharmacological Profile

Dembitsky

2022

Microbiology Research

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: In the proposed review, the pharmacological profile of unique, rare, and unusual fatty acids derived from natural amides is considered. These amides are produced by various microorganisms, lichens, and fungi. The biological activity of some natural fatty acid amides has been determined by their isolation from natural sources, but the biological activity of fatty acids has not been practically studied. According to QSAR data, the biological activity of fatty acids is shown, which demonstrated strong antifungal, antibacterial, antiviral, antineoplastic, anti-inflammatory activities. Moreover, some fatty acids have shown rare activities such as antidiabetic, anti-infective, anti-eczematic, antimutagenic, and anti-psoriatic activities. For some fatty acids that have pronounced biological properties, 3D graphs are shown that show a graphical representation of unique activities. These data are undoubtedly of both theoretical and practical interest for chemists, pharmacologists, as well as for the pharmaceutical industry, which is engaged in the synthesis of biologically active drugs.

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“…201 produced 2-methylheptyl isonicotinate able to inhibit the growth of F. moniliforme more efficiently than a natural analogue (isoniazid) [98]. On the other hand, modest activity was observed by the metabolites extracted from Streptomyces LZ35 against F. verticillioides [104]. For several studies, chitinase activity, rather than antibiotic production, was shown to play a role in the antifungal mechanism [105][106][107][108].…”

Section: Evaluation Of Antifungal Mechanism Of Actionmentioning

confidence: 99%

Critical Assessment of Streptomyces spp. Able to Control Toxigenic Fusaria in Cereals: A Literature and Patent Review

Colombo

Kunova

Cortesi

et al. 2019

IJMS

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Mycotoxins produced by Fusarium species on cereals represent a major concern for food safety worldwide. Fusarium toxins that are currently under regulation for their content in food include trichothecenes, fumonisins, and zearalenone. Biological control of Fusarium spp. has been widely explored with the aim of limiting disease occurrence, but few efforts have focused so far on limiting toxin accumulation in grains. The bacterial genus Streptomyces is responsible for the production of numerous drug molecules and represents a huge resource for the discovery of new molecules. Streptomyces spp. are also efficient plant colonizers and able to employ different mechanisms of control against toxigenic fungi on cereals. This review describes the outcomes of research using Streptomyces strains and/or their derived molecules to limit toxin production and/or contamination of Fusarium species in cereals. Both the scientific and patent literature were analyzed, starting from the year 2000, and we highlight promising results as well as the current pitfalls and limitations of this approach.

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Cuevaenes C–E: Three new triene carboxylic derivatives from Streptomyces sp. LZ35ΔgdmAI

Cited by 7 publications

References 10 publications

Construction of Hydrodibenzo[b,d]furan Frameworks from Morita–Baylis–Hillman Carbonates of Isatins and o-Hydroxy Enones via Palladium and Brønsted Base Relay Catalysis

Construction of Hydrodibenzo[b,d]furan Frameworks from Morita–Baylis–Hillman Carbonates of Isatins and o-Hydroxy Enones via Palladium and Brønsted Base Relay Catalysis

Microbiological Aspects of Unique, Rare, and Unusual Fatty Acids Derived from Natural Amides and Their Pharmacological Profile

Critical Assessment of Streptomyces spp. Able to Control Toxigenic Fusaria in Cereals: A Literature and Patent Review

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