Cue validity modulates the neural correlates of covert endogenous orienting of attention in parietal and frontal cortex

Vossel, Simone; Thiel, Christiane M.; Fink, Gereon R.

doi:10.1016/j.neuroimage.2006.05.019

Cited by 196 publications

(165 citation statements)

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“…Thus, the behavioral effect of nicotine in location-cueing paradigms resembles the effect obtained by manipulating cue validity (ie, the ratio between valid and invalid trials): prior work has shown that decreasing cue validity increases RTs to validly cued targets and decreases RTs to invalidly cued targets (Jonides, 1980;Eriksen and Yeh, 1985;Madden, 1992;Riggio and Kirsner, 1997). Interestingly, this cognitive modulation of attentional reorienting has been observed in studies using peripheral cue stimuli, which are thought to elicit automatic (exogenous) attentional orienting (Eriksen and Yeh, 1985;Madden, 1992) as well as centrally presented cue stimuli inducing voluntary (endogenous) attention shifts (Jonides, 1980;Riggio and Kirsner, 1997;Vossel et al, 2006). Regarding the pharmacological modulation (ie, the nicotine-induced reduction of the validity effect), existing animal and human studies have employed central predictive (Thiel et al, 2005), peripheral predictive (Witte et al, 1997;Murphy and Klein, 1998;Stewart et al, 2001), as well as non-predictive cues (50% cue validity; Phillips et al, 2000).…”

Section: Introductionmentioning

confidence: 73%

“…To avoid confounding effects owing to repeated measurements (Hills and Armitage, 1979;Millar, 1983), we used a between-subject design in which the subjects were randomly assigned to the nicotine or placebo group, respectively (placebo group: six male subjects, six female subjects; mean age 25.7 years; nicotine group: seven male subjects, five female subjects; mean age 24.3 years). The data of the placebo group has been reported separately (Vossel et al, 2006).…”

Section: Subjectsmentioning

confidence: 99%

“…As RT distributions are usually not normally distributed but positively skewed (Heathcote et al, 1991), this procedure allows a more comprehensive analysis of RT data and therefore provides a more detailed characterization of pharmacological effects than traditional RT measures, enabling, for example, the analysis of RT variability. Distributional RT analyses have already been applied in prior studies using location-cueing paradigms (Gottlob, 2004;Vossel et al, 2006). RTs faster than 100 ms (ie, anticipations) were excluded from the analyses.…”

Section: Statistical Analysis Of Behavioral Datamentioning

confidence: 99%

“…We have previously shown that both the manipulation of cholinergic neurotransmission and the manipulation of cue validity modulate reorienting-related brain activity in parietal and temporo-parietal areas (Thiel et al, 2005;Vossel et al, 2006). In particular, in these regions, both nicotinic stimulation and low cue validity reduce neural activity related to attentional reorienting.…”

Section: Introductionmentioning

confidence: 98%

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Behavioral and Neural Effects of Nicotine on Visuospatial Attentional Reorienting in Non-Smoking Subjects

Vossel

Thiel

Fink

2007

Neuropsychopharmacol

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The cholinergic neurotransmitter system has been proposed to be involved in the processing of probabilistic top-down information provided by endogenous cues in location-cueing paradigms. It has been shown that the behavioral and neural effects of a nicotinic cholinergic stimulation resemble the effects obtained by manipulating the validity of the spatial cues: enhancing cortical nicotine levels and decreasing cue validity both reduce the reaction time difference between invalidly and validly cued targets (ie, the 'validity effect') as well as neural activity related to attentional reorienting in parietal brain regions. In the present study, we investigated whether the behavioral and neural effects of nicotine in location-cueing paradigms are dependent upon different a priori cue validities. Twenty-four subjects were investigated in a double-blind placebo-controlled between-subject design with functional magnetic resonance imaging. Nicotine was administered to non-smoking volunteers via polacrilex gums (Nicorette s , 2 mg) before performing a location-cueing paradigm with valid and invalid cues in the context of 90 and 60% cue validity in the MR scanner. Nicotine significantly reduced the validity effect in the 90% but not in the 60% cue validity condition. Fronto-parietal and cingulate regions showed stronger nicotinic reductions of reorientingrelated neural activity in the high than in the low cue validity condition. Our data reveal an interaction effect between the pharmacological and cognitive modulation of attentional reorienting, which is evident at both a behavioral as well as the neuronal level.

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Section: Introductionmentioning

confidence: 73%

Section: Subjectsmentioning

confidence: 99%

Section: Statistical Analysis Of Behavioral Datamentioning

confidence: 99%

Section: Introductionmentioning

confidence: 98%

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Behavioral and Neural Effects of Nicotine on Visuospatial Attentional Reorienting in Non-Smoking Subjects

Vossel

Thiel

Fink

2007

Neuropsychopharmacol

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“…Existing studies that have examined the brain networks underlying detection of behaviorally relevant stimuli have generally defined "relevance" by target features, for example, targets in unexpected locations (Arrington et al, 2000;Kincade et al, 2005;Vossel et al, 2006;Indovina and Macaluso 2007;Doricchi et al, 2010), target-colored distracters (Serences et al, 2005;Hu et al, 2009), or target-relevant cues (Shulman et al, 2009;Geng and Mangun, 2011). These studies have identified a right-lateralized ventral frontoparietal network, including the temporoparietal junction (TPJ) and inferior frontal gyrus (IFG) (Corbetta and Shulman, 2002;Fox et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Contextual Knowledge Configures Attentional Control Networks

DiQuattro¹,

Geng²

2011

J. Neurosci.

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Contextual cues are predictive and provide behaviorally relevant information; they are not the main objective of the current task but can make behavior more efficient. Using fMRI, we investigated the brain networks involved in representing contextual information and translating it into an attentional control signal. Human subjects performed a visual search task for a low-contrast target accompanied by a single non-target that was either perceptually similar or more salient (i.e., higher contrast). Shorter reaction times (RTs) and higher accuracy were found on salient trials, suggesting that the salient item was rapidly identified as a non-target and immediately acts as a spatial "anti-cue" to reorient attention to the target. The relative saliency of the non-target determined BOLD responses in the left temporoparietal junction (TPJ) and inferior frontal gyrus (IFG). IFG correlated with RT specifically on salient non-target trials. In contrast, bilateral dorsal frontoparietal regions [including the frontal eye fields (FEFs)] were correlated with RT in all conditions. Effective connectivity analyses using dynamic causal modeling found an excitatory pathway from TPJ to IFG to FEF, suggesting that this was the pathway by which the contextual cue was translated into an attentional control signal that facilitated behavior. Additionally, the connection from FEF to TPJ was negatively modulated during target-similar trials, consistent with the inhibition of TPJ by dorsal attentional control regions during top-down serial visual search. We conclude that left TPJ and IFG form a sensory-driven network that integrates contextual knowledge with ongoing sensory information to provide an attentional control signal to FEF.

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Disrupted Functional Connectivity in Dorsal and Ventral Attention Networks During Attention Orienting in Autism Spectrum Disorders

et al. 2014

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The DAN analysis suggests that the ASD group has weaker coherence between brain areas involved in goal-driven, endogenous attention control. The strong positive functional connectivity exhibited by the ASD group in the VAN during the invalid trials suggests that individuals with ASD may generate compensatory mechanisms to achieve neurotypical behaviour. These results support the theory of abnormal cortical connectivity in autism.

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Cue validity modulates the neural correlates of covert endogenous orienting of attention in parietal and frontal cortex

Cited by 196 publications

References 43 publications

Behavioral and Neural Effects of Nicotine on Visuospatial Attentional Reorienting in Non-Smoking Subjects

Behavioral and Neural Effects of Nicotine on Visuospatial Attentional Reorienting in Non-Smoking Subjects

Contextual Knowledge Configures Attentional Control Networks

Disrupted Functional Connectivity in Dorsal and Ventral Attention Networks During Attention Orienting in Autism Spectrum Disorders

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