Cucurbitane-type triterpenes and glycoside from the rattan of wild Momordica charantia and their anti-inflammatory and cytotoxic activities

Lj, Zhang; Huang, HT; Liaw, CC; Huang, Sy; Lin, Zongkai; Kuo, Yao‐Haur

doi:10.1055/s-0036-1596595

Cited by 3 publications

(1 citation statement)

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“…In another study, eight new cucurbitane-type glycosides, kugua saponins A–H and six known compounds, were isolated by the directed fractionation of M. charantia fruits [ 81 ]. Zhang et al [ 82 ] also reported that four new cucurbitane-type triterpenes, (23 R )-7β-hydroxy-3β- O -malonyl-23-methoxycucurbita-5,24-diene-19-al, (23 E )-7β,25-dihydroxy-3β- O -methylmalonylcucurbita-5,23-diene-19-al, (23 E )-7β-hydroxy-3β- O -methylmalonyl-25-methoxycucurbita-5,23-diene-19-al, (23 E )-7β,25-dihydroxy-3β- O -crotonylcucurbita-5,23-diene-19-al, and one new glycoside 7β-hydroxy-3β- O -malonyl-cucurbita-5,24-diene-19-a-23- O -β- d -glucopyranoside, were isolated from the rattans of wild M. charantia .…”

Section: Chemical Compositionmentioning

confidence: 99%

Recent Advances in Momordica charantia: Functional Components and Biological Activities

Jia

Shen

Zhang

et al. 2017

IJMS

284

173

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Momordica charantia L. (M. charantia), a member of the Cucurbitaceae family, is widely distributed in tropical and subtropical regions of the world. It has been used in folk medicine for the treatment of diabetes mellitus, and its fruit has been used as a vegetable for thousands of years. Phytochemicals including proteins, polysaccharides, flavonoids, triterpenes, saponins, ascorbic acid and steroids have been found in this plant. Various biological activities of M. charantia have been reported, such as antihyperglycemic, antibacterial, antiviral, antitumor, immunomodulation, antioxidant, antidiabetic, anthelmintic, antimutagenic, antiulcer, antilipolytic, antifertility, hepatoprotective, anticancer and anti-inflammatory activities. However, both in vitro and in vivo studies have also demonstrated that M. charantia may also exert toxic or adverse effects under different conditions. This review addresses the chemical constituents of M. charantia and discusses their pharmacological activities as well as their adverse effects, aimed at providing a comprehensive overview of the phytochemistry and biological activities of M. charantia.

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Section: Chemical Compositionmentioning

confidence: 99%

Recent Advances in Momordica charantia: Functional Components and Biological Activities

Jia

Shen

Zhang

et al. 2017

IJMS

284

173

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Effectiveness of Antihyperglycemic Effect of Momordica charantia: Implication of T‐Cell Cytokines

Fachinan

Yessoufou

Nekoua

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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Background/Objective We investigate the effect of antidiabetic Momordica charantia fruit juice on T cells' differentiation, through plasmatic cytokine quantification in type 1 diabetic rats (T1D). Methods Male Wistar rats were rendered diabetic by the injection of five low doses of streptozotocin. Then, animals were treated with Momordica charantia fruit juice for 28 consecutive days. Plasmatic levels of Th1 interleukin- (IL-) 02 and interferon- (IFN-) γ, Th2 (IL-4), and regulatory (IL-10) cytokines were determined in rats. Results We observed that fruit juice induced a significant decrease in blood glucose of T1D rats. Besides, the concentrations of IL-2 and IFN-γ significantly increased while those of IL-4 and IL-10 diminished in diabetic rats compared to control animals. Interestingly, after treatment with Momordica charantia fruit juice, IL-4 and IL-10 levels significantly increased in diabetic rats, while IL-2 and IFN-γ concentrations decreased, suggesting a Th2 phenotype in these animals. Phytochemical analysis of the fruit juice revealed the presence of tannins, flavonoids, and coumarins, compounds which possess antioxidant activity. Conclusion This study shows that Momordica charantia fruit juice, by lowering the hyperglycemia, induced a shift of proinflammatory Th1 phenotype in T1D rats towards a favorable anti-inflammatory Th2 status. These effects might be due to the presence of antioxidant compounds in the juice and confirms the use of this plant in the treatment of autoimmune type 1 diabetes.

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Evidence of Immunosuppressive and Th2 Immune Polarizing Effects of Antidiabetic Momordica charantia Fruit Juice

Fachinan

Fagninou

Nekoua

et al. 2017

BioMed Research International

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The mechanism of action of the antidiabetic capacity of Momordica charantia is still under investigation. Here, we assessed phytochemical compositions, antioxidant activity, and effects of total and filtered fruit and leafy stem juices of Momordica charantia on human T cell proliferation and differentiation through quantification of Th1/Th2 cytokines. In the absence of stimulation, total fruit and leafy stem juices induced significant T cell proliferation. Under PHA stimulation, both juices potentiated plant-induced T cell proliferation. However, the filtered fruit and leafy stem juices significantly inhibited PHA-stimulated T cell proliferation, while neither juice influenced T cell proliferation. Moreover, total and filtered fruit juice increased IL-4 secretion, while total and filtered leafy stem juice enhanced IFN-γ production. Phytochemical screening revealed the presence of tannins, flavonoids, anthocyans, steroids, and triterpenoids in both juices. Alkaloids, quinone derivatives, cardenolides, and cyanogenic derivatives were undetectable. The saponins present in total juices were undetectable after filtration. Moreover, both juices had appreciable antioxidant capacity. Our study supports the type 1 antidiabetic effect of filtered fruit juice of M. charantia which may be related to its immunosuppressive and T-helper 2 cell inducing capacities. Due to their immune-stimulatory activities and their ability to increase T-helper 1 cell cytokines, total fruit and leafy stem juices may serve in the treatment of immunodeficiency and certain infections.

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Cucurbitane-type triterpenes and glycoside from the rattan of wild Momordica charantia and their anti-inflammatory and cytotoxic activities

Cited by 3 publications

References 0 publications

Recent Advances in Momordica charantia: Functional Components and Biological Activities

Recent Advances in Momordica charantia: Functional Components and Biological Activities

Effectiveness of Antihyperglycemic Effect of Momordica charantia: Implication of T‐Cell Cytokines

Evidence of Immunosuppressive and Th2 Immune Polarizing Effects of Antidiabetic Momordica charantia Fruit Juice

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