Cucurbit[7]uril Enhances Distance Measurements of Spin-Labeled Proteins
Zhimin Yang,
Richard A. Stein,
Maren Pink
et al.
Abstract:We
report complex formation between the chloroacetamide 2,6-diazaadamantane
nitroxide radical (ClA-DZD) and cucurbit[7]uril (CB-7), for which
the association constant in water, K
a =
1.9 × 106 M–1, is at least 1 order
of magnitude higher than the previously studied organic radicals.
The radical is highly immobilized by CB-7, as indicated by the increase
in the rotational correlation time, τrot, by a factor
of 36, relative to that in the buffer solution. The X-ray structure
of ClA-DZD@CB-7 shows the encapsulat… Show more
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