Cucurbit[7]uril-Directed Assembly of Colloidal Membrane and Stimuli-Responsive Microcapsules at the liquid–liquid Interface

Meethal, Shafeekh Kulathinte; Sasmal, Ranjan; Pahwa, Meenakshi; Soumya, C; Saha, Nilanjana Das; Agasti, Sarit S.

doi:10.1021/acs.langmuir.7b03554

Cited by 11 publications

(5 citation statements)

References 47 publications

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“…Obviously, such CB‐derived systems often show large changes in constitution upon electrochemical stimulation, addition of competitive binders, changes in the ion intensity of the solution or changes in the pH of the medium, due to the changes in the binding affinities in CB–guest 9 . Therefore, many studies have focused on systems based on responsiveness in the host–guest chemistry of CBs 9–16 . The applications of stimuli‐responsive CBs can be further expanded by anchoring them onto polymers.…”

Section: Introductionmentioning

confidence: 99%

Synthesis of cucurbit[6]uril pendent upper critical solution temperature type copolymers: self‐assembly and multi‐stimuli‐responsive behavior

Yang

Pei

et al. 2021

Polymer International

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Cucurbit[6]uril‐derivatized vinyl monomer (cucurbit[6]uril methacrylate) was synthesized. Acrylic acid (AA) was used as the comonomer for copolymerization with the cucurbit[6]uril‐derivatized monomer. A series of copolymers of poly(acrylic acid‐co‐cucurbit[6]uril methacrylate) (PAA‐co‐CB[6]MA) were synthesized by free radical polymerization. The cucurbit[6]uril‐derivatized monomer and PAA‐co‐CB[6]MA copolymers were characterized by 1H NMR spectra, high‐resolution mass spectroscopy and gel permeation chromatography. The solution behavior was examined using UV–visible spectroscopy and dynamic light scattering. The PAA‐co‐CB[6]MA showed an upper critical solution temperature (UCST) in water. The UCST‐type thermoresponsive behavior of these CB[6]‐derivatized copolymers was highly dependent on the composition of the copolymer. For the same type of copolymer, changes in its composition gave rise to different UCSTs. Additionally, the PAA‐co‐CB[6]MA copolymers were successful in trapping azocarmine B. The stimuli‐responsive release of encapsulated azocarmine B was achieved by a combination of temperature and pH value stimuli. According to the results, the novel PAA‐co‐CB[6]MA copolymers can be used as carriers. © 2021 Society of Industrial Chemistry.

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Section: Introductionmentioning

confidence: 99%

Synthesis of cucurbit[6]uril pendent upper critical solution temperature type copolymers: self‐assembly and multi‐stimuli‐responsive behavior

Yang

Pei

et al. 2021

Polymer International

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“…Our sensing strategy employs surface-functionalized AuNPs ( d ∼ 4 nm) as a scaffold for receptor design. AuNP was uniquely selected for this purpose due to its comparable size to biomolecules, tunable surface property, excellent stability, biocompatibility, and broad-spectrum fluorescence quenching ability. − Three surface-functionalized AuNPs (AuNMe 3 , AuNMe 2 Bn, and AuNMe 2 Hexyl) were prepared via the place exchange reaction. , AuNPs bearing cationic head groups offer electrostatic complementarity against fluorophore-labeled ssDNA strands, thus allowing formation of noncovalent AuNP–DNA complexes with concomitant quenching of DNA fluorescence by the gold core. The chemical features of the head group further tune the binding interaction in such complexes.…”

Section: Resultsmentioning

confidence: 99%

Multichannel DNA Sensor Array Fingerprints Cell States and Identifies Pharmacological Effectors of Catabolic Processes

Saha¹,

Sasmal²,

Meethal³

et al. 2019

ACS Sens.

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Cells at disease onset are often associated with subtle changes in the expression level of a single or few molecular components, making traditionally used biomarker-driven clinical diagnosis a challenging task. We demonstrate here the design of a DNA nanosensor array with multichannel output that identifies the normal or pathological state of a cell based on the alteration of its global proteomic signature. Fluorophore-encoded single-stranded DNA (ssDNA) strands were coupled via supramolecular interaction with a surface-functionalized gold nanoparticle quencher to generate this integrated sensor array. In this design, ssDNA sequences exhibit dual roles, where they provide differential affinities with the receptor gold nanoparticle as well as act as transducer elements. The unique interaction mode of the analyte molecules disrupts the noncovalent supramolecular complexation, generating simultaneous multichannel fluorescence output to enable signature-based analyte identification via a linear discriminant analysis-based machine learning algorithm. Different cell types, particularly normal and cancerous cells, were effectively distinguished using their fluorescent fingerprints. Additionally, this DNA sensor array displayed excellent sensitivity to identify cellular alterations associated with chemical modulation of catabolic processes. Importantly, pharmacological effectors, which could modulate autophagic flux, have been effectively distinguished by generating responses from their global protein signatures. Taken together, these studies demonstrate that our multichannel DNA nanosensor is well suited for rapid identification of subtle changes in a complex mixture and thus can be readily expanded for point-of-care clinical diagnosis, high-throughput drug screening, or predicting the therapeutic outcome from a limited sample volume.

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“…As complexation with Q7 improved the rigidity of the otherwise loose FGGC peptide composed of the nanocluster shell, FGGC-AuNCs@Q7 showed a significant red fluorescent emission at 640 nm in an aqueous medium due to the suppression of nonradiative transition similar to aggregation-induced emission (AIE) phenomenon. 20,21 Importantly, specific recognition between Q7 and FEN triggered the displacement of Q7 from the nanocluster periphery through competitive binding, resulting in simultaneous fluorescence response with a high correlation of FEN abundance, as shown in Fig. 1.…”

Section: Introductionmentioning

confidence: 96%

Cucurbituril-protected dual-readout gold nanoclusters for sensitive fentanyl detection

Wang

Zhu

et al. 2023

Analyst

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Cucurbit[7]uril-Directed Assembly of Colloidal Membrane and Stimuli-Responsive Microcapsules at the liquid–liquid Interface

Cited by 11 publications

References 47 publications

Synthesis of cucurbit[6]uril pendent upper critical solution temperature type copolymers: self‐assembly and multi‐stimuli‐responsive behavior

Synthesis of cucurbit[6]uril pendent upper critical solution temperature type copolymers: self‐assembly and multi‐stimuli‐responsive behavior

Multichannel DNA Sensor Array Fingerprints Cell States and Identifies Pharmacological Effectors of Catabolic Processes

Cucurbituril-protected dual-readout gold nanoclusters for sensitive fentanyl detection

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