Cucurbit[6]uril-functionalized Fe3O4 magnetic nanoparticles for pH-responsive drug delivery

Liu, Dan; Huang, Liping; Li, Tongyi; Zhang, Guohua; Ni, Qingting

doi:10.1007/s11696-022-02147-7

Cited by 1 publication

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“…The previous study reported the ratio between Fe 2+ and Fe 3+ is 1:2, but ignored the effect of other ratios that can possibly produce smaller size of Fe 3 O 4 NPs considering other factor such as pH. On the other hand, desired pH of solution was selected as factor in this study because to avoid any excess of ammonium hydroxide (ammonia) that used as volume (ml) in previous studies, which have been influenced on particle growth (Liu et al 2022). This study shows complex interactions between factors that can be controlled to produce the minimum possible size of Fe 3 O 4 NPs, which is not reported elsewhere.…”

Section: Introductionmentioning

confidence: 99%

Optimizing and control of effective synthesize parameters for Fe3O4 nanoparticles using response surface methodology

et al. 2022

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To control Fe3O4 nanoparticles (Fe3O4 NPs) size, different molar ratio of Fe2+ and Fe3+ as well as ammonium hydroxide (pH) was used to synthesize Fe3O4 NPs through co-precipitation method. The Box–Behnken design was selected to explore the interaction between process parameters (factors) such as Fe2+ molar ion, Fe3+ molar ion and pH on the final size. The interactive effect between the process variables was evaluated by analysis of variance (ANOVA). The quadratic model predicted by the Box–Behnken design was significant with a P value of < 0.0001. The optimum synthesis conditions were predicted by the model indicating optimum size obtained using 1.00 mol Fe2+ ion with 3.00 mol Fe3+ ion with pH at 12.00. From the experiment, the particle size was 10 ± 2 nm at optimum conditions, while the model predicted a particle size of 6.80 nm. The magnetic properties of Fe3O4 NPs were displayed typical ferromagnetic behavior with saturation magnetization value to be 49.729 emu/g. Finally, the optimized Fe3O4 NPs showed about 80% removal of Congo red (CR) dye, which confirms their applicability in adsorption process for future applications.

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Section: Introductionmentioning

confidence: 99%