Cubic phase nanoparticles for sustained release of ibuprofen formulation characterization and enhanced bioavailability study

Dian, Linghui; Yang, Zhiwen; Li, Feng; Wang, Zhouhua; Pan, Xin; Peng, Xinsheng; Huang, Xintian; Guo, Zhefei; Quan, Guilan; Shi, Xuan; Bao, Chen; Li, Ge; Wu, Chuanbin

doi:10.2147/ijn.s40547

Cited by 31 publications

(3 citation statements)

References 40 publications

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“…The potential of cubosomes to provide a slow release matrix for drugs of varying sizes and polarity has been reported 48 , 49 , 50 , 51 , 52 . However, the present results demonstrate that the overall release of 5-FU from cubosomes is relatively rapid compared to the reported slow and sustained release of other drugs incorporated into cubosomes 53 , 54 . It should be noted that the latter drugs are considerably more lipid soluble than 5-FU, a water soluble compound.…”

Section: Resultscontrasting

confidence: 54%

In vitro and in vivo evaluation of cubosomes containing 5-fluorouracil for liver targeting

Nasr

Ghorab

Abdelazem

2015

Acta Pharmaceutica Sinica B

171

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The objective of this study was to prepare cubosomal nanoparticles containing a hydrophilic anticancer drug 5-fluorouracil (5-FU) for liver targeting. Cubosomal dispersions were prepared by disrupting a cubic gel phase of monoolein and water in the presence of Poloxamer 407 as a stabilizer. Cubosomes loaded with 5-FU were characterized in vitro and in vivo. In vitro, 5-FU-loaded cubosomes entrapped 31.21% drug and revealed nanometer-sized particles with a narrow particle size distribution. In vitro 5-FU release from cubosomes exhibited a phase of rapid release of about half of the entrapped drug during the first hour, followed by a relatively slower drug release as compared to 5-FU solution. In vivo biodistribution experiments indicated that the cubosomal formulation significantly (P<0.05) increased 5-FU liver concentration, a value approximately 5-fold greater than that observed with a 5-FU solution. However, serum serological results and histopathological findings revealed greater hepatocellular damage in rats treated with cubosomal formulation. These results demonstrate the successful development of cubosomal nanoparticles containing 5-FU for liver targeting. However, further studies are required to evaluate hepatotoxicity and in vivo antitumor activity of lower doses of 5-FU cubosomal formulation in treatment of liver cancer.

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Section: Resultscontrasting

confidence: 54%

In vitro and in vivo evaluation of cubosomes containing 5-fluorouracil for liver targeting

Nasr

Ghorab

Abdelazem

2015

Acta Pharmaceutica Sinica B

171

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“…Polymeric nanospheres are used to detect cancer cells. Dendrimers, quantum dots, SPIONs, and nanoshells are applied in imaging technology as well as for drug delivery in cancer treatment [ 10 , 12 - 14 ].…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial properties of nanomolecules: potential candidates as antibiotics in the era of multi-drug resistance

Kandi¹,

Kandi

2015

Epidemiol Health

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OBJECTIVES:The emergence of multi-drug resistance among various microbial pathogens has been a cause of serious concern to the medical world, limiting the choice of antibiotics. Considering that it may take decades to synthesize new antimicrobial drugs that combat resistant pathogens, the search for alternatives to conventional antimicrobial agents has begun.METHODS:In his paper we attempted to review the physico-chemical properties of nanoparticles, their modes of action and potential use in medicine and research with special reference to antimicrobial properties.RESULTS:Nanomolecules and nanoparticles have in recent years been extensively studied for their utility not only as antibiotics but also as vehicles to carry antibiotics or other agents such as cancer chemotherapeutics to target sites and limit damage to host cells.CONCLUSION:Nanomolecules were positively evaluated for their antimicrobial activities. Anti-biofilm activities of nanoparticles, utility of nanomaterials as carrier agents of drugs signifies their importance in medicine and research.

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“…Many efforts have been devoted to the development of oral sustained-release systems that can not only improve drug bioavailability leading to better efficacy and less administration frequencies but also decrease the fluctuation of plasma drug concentration to lower side effects [ 2 ]. In recent decades, emerging nanotechnology provides a novel platform to solve the solubility problem of drugs [ 3 , 4 ]. Especially, polymeric micelles as a promising drug delivery system is a new research hotspot [ 5 ], most current studies concentrated on developing polymeric micelles for injection drug delivery [ 6 ].…”

Section: Introductionmentioning

confidence: 99%

Enhancing oral bioavailability of quercetin using novel soluplus polymeric micelles

et al. 2014

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To improve its poor aqueous solubility and stability, the potential chemotherapeutic drug quercetin was encapsulated in soluplus polymeric micelles by a modified film dispersion method. With the encapsulation efficiency over 90%, the quercetin-loaded polymeric micelles (Qu-PMs) with drug loading of 6.7% had a narrow size distribution around mean size of 79.00 ± 2.24 nm, suggesting the complete dispersibility of quercetin in water. X-ray diffraction (XRD) patterns illustrated that quercetin was in amorphous or molecular form within PMs. Fourier transform infrared spectroscopy (FTIR) indicated that quercetin formed intermolecular hydrogen bonding with carriers. An in vitro dialysis test showed the Qu-PMs possessed significant sustained-release property, and the formulation was stable for at least 6 months under accelerated conditions. The pharmacokinetic study in beagle dogs showed that absorption of quercetin after oral administration of Qu-PMs was improved significantly, with a half-life 2.19-fold longer and a relative oral bioavailability of 286% as compared to free quercetin. Therefore, these novel soluplus polymeric micelles can be applied to encapsulate various poorly water-soluble drugs towards a development of more applicable therapeutic formulations.

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Cubic phase nanoparticles for sustained release of ibuprofen formulation characterization and enhanced bioavailability study

Cited by 31 publications

References 40 publications

In vitro and in vivo evaluation of cubosomes containing 5-fluorouracil for liver targeting

In vitro and in vivo evaluation of cubosomes containing 5-fluorouracil for liver targeting

Antimicrobial properties of nanomolecules: potential candidates as antibiotics in the era of multi-drug resistance

Enhancing oral bioavailability of quercetin using novel soluplus polymeric micelles

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