Cuantificación inmunomagnética de células tumorales circulantes en pacientes con cáncer de próstata: correlación clínica y patológica

Folkersma, L. Resel; Gómez, C. Olivier; Manso, L.; Veganzones, Silvia; Romo, I. Galante; Lázaro, Marta Vidaurreta; Orden, GV De la; Fernández, Miguel A. García; Rubio, Eduardo Díaz; Moyano, A. Silmi; Casas, Miguel García

doi:10.4321/s0004-06142010000100004

Cited by 12 publications

(2 citation statements)

References 17 publications

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“…To date, CellSearch System (Veridex) was approved by FDA for clinical use in breast, colorectal, and prostate cancers (11)(12)(13). The system immunomagnetically enriches CTCs expressing EpCAM from 7.5 mL of blood using ferrofluids beads coated with anti-EpCAM antibodies and then selects fluorescently cells based on DAPI, CD45-APC, and 8, 18 and 19 CK-PE.…”

Section: Circulating Tumor Cells (Ctcs)mentioning

confidence: 99%

Clinical Applications of Liquid Biopsy in Gastric Cancer

Chivu‐Economescu¹,

Necula²,

Matei³

et al. 2021

Front. Med.

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Liquid biopsy represents an exciting new area in the field of cancer diagnosis and management, offering a less invasive and more convenient approach to obtain a time-point image of the tumor burden and its genomic profile. Samples collected from several body fluids, mostly blood, can be used to gain access to circulating tumor cells and DNA, non-coding RNAs, microRNAs, and exosomes, at any moment, offering a dynamic picture of the tumor. For patients with GC, the use of blood-based biopsies may be particularly beneficial since tissue biopsies are difficult to obtain and cause real distress to the patient. With advantages such as repeatability and minimal invasion, it is no wonder that the field of liquid biopsy has received tremendous attention. However, the abundance of studies, involving a wide range of assays with different principles, prevented for the moment the reproducibility of the results and therefore the translation into the clinic of liquid biopsy. In this review, we present the latest technical development and data on circulating biomarkers available through liquid biopsy in gastric cancer with an emphasis on their clinical utility in areas such as cancer screening, prognostic stratification, and therapeutic management.

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Section: Circulating Tumor Cells (Ctcs)mentioning

confidence: 99%

Clinical Applications of Liquid Biopsy in Gastric Cancer

Chivu‐Economescu¹,

Necula²,

Matei³

et al. 2021

Front. Med.

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show abstract

“…-En cáncer de próstata metastático las CTC predicen una SLE y una SG más corta. Se ha demostrado una correlación positiva entre el número de CTC y los valores de PSA, con el tamaño del tumor y con la presencia o no de adenopatías 9 . Los hallazgos confirman que las cantidades de CTC antes del tratamiento ayudan a predecir la supervivencia de los pacientes de cáncer de próstata que inician la quimioterapia de primera línea.…”

Section: Aplicaciones Clínicasunclassified

Actualidad y futuro en las técnicas de cuantificiación de células tumorales circulantes: su importancia en tumores sólidos epiteliales

Sua

Pérez

Lázaro

et al. 2011

Revista del Laboratorio Clínico

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Tumor‐proximal liquid biopsy to improve diagnostic and prognostic performances of circulating tumor cells

et al. 2019

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Circulating tumor cell ( CTC ) detection and numeration are becoming part of the common clinical practice, especially for breast, colon, and prostate cancer. However, their paucity in peripheral blood samples is an obstacle for their identification. Several groups have tried to improve CTC recovery rate by developing highly sensitive cellular and molecular detection methods. However, CTC s are still difficult to detect in peripheral blood. Therefore, their recovery rate could be increased by obtaining blood samples from vessels close to the drainage territories of the invaded organ, when the anatomical situation is favorable. This approach has been tested mostly during tumor resection surgery, when the vessels nearest to the tumor are easily accessible. Moreover, radiological (including echo‐guided based and endovascular techniques) and/or endoscopic routes could be utilized to obtain CTC samples close to the tumor in a less invasive way than conventional biopsies. The purpose of this article is to summarize the available knowledge on CTC recovery from blood samples collected close to the tumor (i.e., in vessels located in the drainage area of the primary tumor or metastases). The relevance of such an approach for diagnostic and prognostic evaluations will be discussed, particularly for pancreatic ductal adenocarcinoma, colorectal adenocarcinoma, hepatocellular carcinoma, and non‐small‐cell lung cancer.

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Cuantificación inmunomagnética de células tumorales circulantes en pacientes con cáncer de próstata: correlación clínica y patológica

Cited by 12 publications

References 17 publications

Clinical Applications of Liquid Biopsy in Gastric Cancer

Clinical Applications of Liquid Biopsy in Gastric Cancer

Actualidad y futuro en las técnicas de cuantificiación de células tumorales circulantes: su importancia en tumores sólidos epiteliales

Tumor‐proximal liquid biopsy to improve diagnostic and prognostic performances of circulating tumor cells

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