Cuándo se considera positivo el test de broncodilatación

Martínez, Cecilia; Fernández-Espinar, J. Fuertes; Puerta, Isabel Nerín de la; Perez-Yarza, Y. E. Gonzalez

doi:10.1016/s1695-4033(02)77885-5

Cited by 10 publications

(4 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…, 20 For FEF 25-75% , the cut-off point found in the present study (a change of 61% from baseline in response to bronchodilator use) is different from those found by Borrego et al (33%) 18 and other authors (25%, with a sensitivity of 41% and a specificity of 80%) 1 . Unlike the present study, the aforementioned studies were both case-control studies, and this might explain these discrepancies.…”

Section: Discussioncontrasting

confidence: 99%

“…Although some studies have included FEF 25-75% in the analysis of bronchodilator response, 1 , 19 , 20 FEF 25-75% is not given weight in studies evaluating bronchodilator response, because it varies widely 6 20 For FEF 25-75% , the cut-off point found in the present study (a change of 61% from baseline in response to bronchodilator use) is different from those found by Borrego et al (33%) 18 and other authors (25%, with a sensitivity of 41% and a specificity of 80%) 1 .…”

Section: Discussionmentioning

confidence: 99%

“…We calculated the sample size required to achieve a mean increase in FEV 0.75 , after bronchodilator use, of 4.5% and a standard deviation of 5.1%, a value found in a study by Borrego et al, 18 with 95% confidence, assuming an estimation error of 1%, in accordance with the sample size calculation of Pardos et al 20 The minimum sample size was calculated to be 100. …”

Section: Methodsmentioning

confidence: 99%

See 2 more Smart Citations

Bronchodilator response cut-off points and FEV 0.75 reference values for spirometry in preschoolers

et al. 2016

View full text Add to dashboard Cite

Objective:To determine the cut-off points for FEV1, FEV0.75, FEV0.5, and FEF25-75% bronchodilator responses in healthy preschool children and to generate reference values for FEV0.75. Methods:This was a cross-sectional community-based study involving children 3-5 years of age. Healthy preschool children were selected by a standardized questionnaire. Spirometry was performed before and after bronchodilator use. The cut-off point of the response was defined as the 95th percentile of the change in each parameter. Results:We recruited 266 children, 160 (60%) of whom were able to perform acceptable, reproducible expiratory maneuvers before and after bronchodilator use. The mean age and height were 57.78 ± 7.86 months and 106.56 ± 6.43 cm, respectively. The success rate for FEV0.5 was 35%, 68%, and 70% in the 3-, 4-, and 5-year-olds, respectively. The 95th percentile of the change in the percentage of the predicted value in response to bronchodilator use was 11.6%, 16.0%, 8.5%, and 35.5% for FEV1, FEV0.75, FEV0.5, and FEF25-75%, respectively. Conclusions:Our results provide cut-off points for bronchodilator responsiveness for FEV1, FEV0.75, FEV0.5, and FEF25-75% in healthy preschool children. In addition, we proposed gender-specific reference equations for FEV0.75. Our findings could improve the physiological assessment of respiratory function in preschool children.

show abstract

Section: Discussioncontrasting

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

See 1 more Smart Citation

Bronchodilator response cut-off points and FEV 0.75 reference values for spirometry in preschoolers

et al. 2016

View full text Add to dashboard Cite

show abstract

“…International studies have also shown that a BDR threshold of > 12% was ineffective, and that > 9% or > 8% had better sensitivity and specificity. Although some studies have shown BDR are different in different races [24], previous results are generally consistent with ours [4–6, 25].…”

Section: Discussionsupporting

confidence: 92%

A clinical study to determine the threshold of bronchodilator response for diagnosing asthma in Chinese children

2019

View full text Add to dashboard Cite

BackgroundThere is few objective, clinically feasible and inexpensive test for diagnosing childhood asthma. We want to find an ideal way to solve it.MethodsThe control group was 301 non-asthmatic children, and the asthma group was 286 asthmatic children. The asthmatic children were divided into three groups according to the severity of their disease. Pre- and post-bronchodilator spirometer tests were performed, and the main spirometer parameters were compared. The bronchodilator response (BDR) [BDR is used to determine the reversibility of airway obstruction by measuring the changes of forced expiratory volume in the first second (FEV1) before and after inhalation of bronchodilators] was then determined, and the optimal threshold of BDR for diagnosing childhood asthma was found.Results301 non-asthmatic children and 286 asthmatic children participated in the study, the demographics were similar. FEV1 for pre-bronchodilator of asthmatic children was significantly lower than that of non-asthmatic children (P ≤ 0.01). BDR of non-asthmatic children was 3.30 ± 3.85%. BDR of asthmatic children was 9.45 ± 9.15%. There was no significant difference in BDR for patients with different severities of asthma within the group. BDR had no statistical correlation with gender, age, height, weight in neither non-asthmatic children nor asthmatic children. On the receiver-operating characteristic curve, a BDR threshold of ≥ 7.5% offered an optimal balance in asthma diagnosis with a sensitivity rate of 50.7% and specificity rate of 87.7%. Meanwhile, with a BDR threshold of ≥ 12%, the sensitivity rate was 28.7% and the specificity rate was 96.3%.ConclusionA BDR threshold of ≥ 7.5% has more value in childhood asthma diagnosis as compared to ≥ 12%.Electronic supplementary materialThe online version of this article (10.1007/s12519-019-00293-9) contains supplementary material, which is available to authorized users.

show abstract

Prueba de broncodilatación: ¿9% sobre el valor teórico o 12% sobre el valor basal es lo mismo?

Neyra

Asensi

Atauri

et al. 2009

Anales de Pediatría

View full text Add to dashboard Cite

Cuándo se considera positivo el test de broncodilatación

Cited by 10 publications

References 18 publications

Bronchodilator response cut-off points and FEV 0.75 reference values for spirometry in preschoolers

Bronchodilator response cut-off points and FEV 0.75 reference values for spirometry in preschoolers

A clinical study to determine the threshold of bronchodilator response for diagnosing asthma in Chinese children

Prueba de broncodilatación: ¿9% sobre el valor teórico o 12% sobre el valor basal es lo mismo?

Contact Info

Product

Resources

About