“…[9][10][11][12][13][14] A variety of ligand-type synthetic nucleosides have been reported to form metalmediated base pairs in the presence of certain metal ions such as Ag I , Hg II , Cu II , and Ni II . Metal-mediated base pairing usually leads to the thermal stabilization of DNA duplexes, which has recently been applied to metal-dependent allosteric regulation of DNAzymes (catalytic DNAs) [15][16][17][18][19] and DNA aptamers. 20,21 In particular, Cu II -mediated artificial base pairing has contributed significantly to imparting DNAs with attractive properties such as magnetism, 22,23 catalytic activity, 24 and redox responsiveness.…”