Cu2+-Pyropheophorbide a-Cystine Conjugate: Synergistic Photodynamic/Chemodynamic Therapy and Glutathione Depletion Improves the Antitumor Efficacy and Downregulates the Hypoxia-Inducing Factor
Zhongping Su,
Haiying Xu,
Hui Zhang
et al.
Abstract:Cancer
immune escape, metastasis, recurrence, and multidrug
resistance
are all associated with hypoxia in the tumor microenvironment (TME).
We synthesized a CuPPaCC conjugate for reactive oxygen species (ROS)-mediated
cancer therapy. CuPPaCC continuously produced cytotoxic ROS and oxygen
through a photo-chemocycloreaction, alleviated hypoxia, and inhibited
the expression of a hypoxia-inducing factor (HIF-1α). CuPPaCC
was synthesized from pyromania phyllophyllic acid a (PPa), cystine
(CC), and copper ions, and … Show more
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