Cu(ii) salts as terminal oxidants in visible-light photochemical oxidation reactions

Abstract

A review of new oxidative photocatalytic methods enabled by the use of copper(ii) salts as convenient, earth-abundant, cost-effective terminal oxidants.

Diverting the Mannich reaction to access 2,2-disubstituted indolin-3-ones by merging 1,2-aryl migration and copper-catalyzed aerobic oxidation

“…Only limited oxidative Cu( ii ) species were beneficial for the reaction, consistent with Yoon's inspiring discovery. 25 We believe that Cu( ii ) acts as both a Lewis acid and an oxidant in our reaction. By reducing 5a , we can detect the production of the intermediate C by crude NMR, but this compound is very unstable, and it is easily oxidized and converted back to 5a as determined by column chromatographic separation (Scheme 5d).…”