Cu(OTf)₂/HFIP catalyzed regioselective cycloisomerization of indole-C3-functionalized alkynols to carbazoles

Abstract

We report here a simple and atom economic cycloisomerization reaction of indole-tethered alkynols for constructing diverse carbazoles using Cu(OTf)2/HFIP as the excellent promoter system. The reaction proceeds through a one-pot,...

Hexafluoroisopropanol (HFIP)-Mediated Intramolecular Cyclization of Allenamides To Access C1-Vinyl Tetrahydro-β-carbolines

“…Hexafluoroisopropanol (HFIP), a “magic solvent” with unique reactivity and interesting properties, has received significant attention recently . Having poor nucleophilicity, HFIP promotes various organic reactions by establishing a hydrogen-bond network with strong hydrogen-bond donor properties.…”