Cu/Ni-doped sulfated zirconium oxide immobilized on CdFe2O4 NPs: a cheap, sustainable and magnetically recyclable inorgano-catalyst for the efficient preparation of α-aminonitriles in aqueous media

An Efficient and Rapid Synthesis of α-Aminonitriles via Strecker Reaction Catalyzed by Humic Acid

“…Among these cyanide agents, TMSCN has proven to be relatively safe, easy to handle, highly soluble in organic solvents, and more effective as a cyanide anion source for the nucleophilic addition of imines under mild conditions compared to other cyanating reagents. In recent years, numerous methods have been developed for the synthesis of α-aminonitriles via Strecker reaction using TMSCN as a cyanide source catalyzed by various catalysts, such as MnO-doped Fe 3 O 4 NPs, [11] SiO 2 , [12] Fe 3 O 4 @SiO 2 core-shell MNPs, [13] natural halloysite nanotubes, [14] mandelic acid, [15] Fe 3 O 4 , [16] CeCl 3 , [17] MCM-41, [18] I 2 , [19] polymer, [20] g-C 3 N 4anchored sulfonic acid, [21] ionic liquids, [22] ZnO, [23] Cd-Fe 2 O 4 @SiO 2 @ZrO 2 /SO 4 2 -/Cu/Ni, [24] CMK-5-SO 3 H, [25] Fe 3 O 4 @SiO 2 -APTES-TFA, [26] S m I 3 , [27] Fe 3 O 4 @SiO 2 -NH 2 -GA, [28] metal organic framework (MOFs) [29] and covalent organic frameworks (COFs). [30] Although each of the above methods has its own merit, most of these methods are associated with certain disadvantages including the use of commercially unavailable metal catalysts, organic solvents, low yields and long reaction times.…”