2010
DOI: 10.1002/cctc.201000062
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Cu Nanoparticles in PEG: A New Recyclable Catalytic System for N‐Arylation of Amines with Aryl Halides

Abstract: A new protocol for the N‐arylation of aryl halides with anilines using Cu nanoparticles in polyethylene glycol (PEG) as an efficient and reusable catalytic system has been developed. The reaction did not require any cocatalyst. Various solvents were screened, and PEG400 provided the best results. The studies showed that the mechanism of catalytic action is dependent on the size of the nanoparticles. The Cu nanoparticles and PEG were recyclable and retained their activity. This newly developed protocol was also… Show more

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Cited by 46 publications
(24 citation statements)
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“…Isatin (1H-indole-2,3-dione) is a privileged scaffold and one of the most promising class of heterocycles that possesses diverse interesting activity profiles and well-tolerated in humans [20][21][22] [23][24][25]. Moreover, the efficacy of sunitinib in patients with advanced HCC was evaluated in four phase II studies [26][27][28][29].…”
Section: Figurementioning
confidence: 99%
“…Isatin (1H-indole-2,3-dione) is a privileged scaffold and one of the most promising class of heterocycles that possesses diverse interesting activity profiles and well-tolerated in humans [20][21][22] [23][24][25]. Moreover, the efficacy of sunitinib in patients with advanced HCC was evaluated in four phase II studies [26][27][28][29].…”
Section: Figurementioning
confidence: 99%
“…10 11 The size and shape of these nanocatalysts became an important aspect in catalyst design, which provides a highly active catalyst surface, increasing the reaction rates and decreasing the consumption of the catalyst. 12 13 Furthermore, Cu-grafted functionalized heterogeneous catalysts provide the advantages of simplified isolation of the product, easy recovery, enhanced stability and recyclability of the catalysts over their respective homogeneous counterpart. Thus, researchers are keener for the development of heterogeneous catalysts with the long catalyst life and reusability for several cycles minimizing E factor.…”
Section: Introductionmentioning
confidence: 99%
“…This is because the ligands containing N ‐donors exhibit a high performance by a stable hosting a range of metal cations and as a result, these materials become excellent candidates in catalysis design as well as analytical, industrial and medicinal applications . In comparison, the Cu‐based catalysts have offered excellent alternatives to other noble‐metal‐based catalysts due to their interesting features including low price, facile separation and high catalytic performance 2f, h, 41–46…”
Section: Introductionmentioning
confidence: 99%