Cu/Mn-Catalyzed C–N Cross-Coupling Reaction of Aryl Chlorides and Amines Promoted by a Polyamidoamine Dendrimer

Abstract

A bimetallic catalytic combinations of Mn(OAc)2 and Cu(OAc)2 was found to be significantly effective for the Buchwald type C-N cross coupling of arylchlorides and amines. Reaction is highly influenced in the presence of a promoter Poly(amidoamine) (PAMAM) dendrimer which also possesses the advantages of being stabile, non-toxic, biocompatible, non-immunogenic and acts as soluble support for transition metal complex. Although, Mn is low cost and environmentally benign, but it is not fully exploited due to its low intrinsic catalytic activity. Here, the catalytic potential of Mn was drastically increased in the presence of another metal salt (Cu(OAc)2). In bimetallic composition, Mn significantly influences the activity, selectivity and plays a vital role in catalysis. Herein, we have developed a novel, green and economical procedure for the Buchwald type C-N cross coupling of arylchlorides and amines. Presented coupling method works under aerobic and solvent-free conditions and produces an excellent yield of value-added N-arylated or alkylated products.