Cu(II) salen complex catalyzed synthesis of propargylamines by a three-component coupling reaction

A green approach to the synthesis of Ag doped nano magnetic γ-Fe2O3@SiO2-CD core–shell hollow spheres as an efficient and heterogeneous catalyst for ultrasonic-assisted A3 and KA2 coupling reactions

“…Synthesis of three-component reaction of derivatives aldehyde or cyclic ketone, secondary-amines and terminal alkynes a3,14,[34][35][36] …”

Solvent‐free synthesis of propargylamines catalyzed by an efficient recyclable ZnO‐supported CuO/Al2O3 nanocatalyst

“…According to previous reports, various metal‐based catalysts, including Ag, Fe, Li, Ni, Pd, In and Au, have been reported for the synthesis of propargylamines . In this view, copper and zinc catalysts are the most important for the synthesis of propargylamine derivatives, and good results have been achieved in the presence of these catalysts …”

Shedding light on the use of Cu(ii)-salen complexes in the A3 coupling reaction

“…[42][43][44][45][46] Moreover, in Cu-salen derivatives reversible methanolysis of an azomethine C=N bond can be observed. 47 Bearing all these in mind, we envisaged that a well-characterised Cu(II)-salen derivative would be an efficient vehicle towards the A 3 coupling; recent works support this hypothesis, 48,49 although evidence of the mechanism is uncertain. Inspired by our recent work with salen based ligands, 50 we identified that a Cu(II)-salen compound made with the ligand (H2L) shown in Scheme 1 is an ideal candidate to serve this purpose.…”