Cu(II) doped polyaniline nanoshuttles for multimodal tumor diagnosis and therapy

Lin, Min; Wang, Dandan; Li, Shuyao; Tang, Qi; Liu, Shuwei; Ge, Rui; Liu, Yi; Zhang, Daqi; Sun, Hongchen; Zhang, Hao; Yang, Bai

doi:10.1016/j.biomaterials.2016.07.021

Cited by 48 publications

(34 citation statements)

References 53 publications

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“…as contrast agents for magnetic resonance imaging (MRI) 32 - 34 , which is a precise and free of radiation imaging technique for the diagnosis of soft tissue lesion 35 - 38 . Some of the transitional metal ions also carry certain dosage of toxicity, which can be used as chemotherapeutic drugs for tumor treatment 39 , 40 . Meanwhile, many transitional metal elements are essential to maintaining body health.…”

Section: Introductionmentioning

confidence: 99%

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Tumor Theranostics of Transition Metal Ions Loaded Polyaminopyrrole Nanoparticles

Liu

Wang

et al. 2018

Nanotheranostics

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Polypyrrole (PPy) nanoparticles (NPs) possess high near-infrared absorption and good biosafety, showing the potentials as photothermal therapeutic materials. However, the single function and the weak diagnostic function limit the further combination with other functional units to achieve theranostics. In this work, polyaminopyrrole (PPy-NH2) is demonstrated as the alternative of PPy for preparing NPs. Because of the amino group, metal ions, such as Cu(II) and Fe(III) can be loaded in PPy-NH2 NPs, which extends the applications in multimodal theranostics. Systematical studies reveal that the contribution of Cu(II) in multimodal theranostics is greater than Fe(III). Cu can enhance T1 response signal for magnetic resonance imaging (MRI) and be released controllably in the organism, leading to the effect of chemotherapy. Therefore, Cu(II) and Fe(III) co-loaded PPy-NH2 NPs are defined as CuPPy-NH2 NPs. Experimental results indicate that the optimal size of CuPPy-NH2 NPs is 50.2 nm. The photothermal transduction efficiency is 76.4%. After thermochemotherapy, a complete ablation of human oral epithelial carcinoma tumors is observed. No tumor recurrence is found.Methods: Cu(II) and Fe(III) co-loaded PPy-NH2 NPs are prepared through oxidation polymerization by mixing Py-NH2, CuCl2, and FeCl3 in water under stirring at room temperature, which are defined as CuPPy-NH2 NPs. The as-prepared CuPPy-NH2 NPs are tested with a variety of cell and animal experiments for tumor theranostics.Results: CuPPy-NH2 NPs have good light stability, photothermal stability, biosafety and low toxicity. The optimal size of theranostic CuPPy-NH2 NPs is 50.2 nm, which present a photothermal transduction efficiency of 76.4%. The doped Cu(II) ions also show chemotherapeutic behavior. After thermochemotherapy, a complete ablation of human oral epithelial carcinoma tumors is observed. No tumor recurrence is found. Because of the unpaired electron in Cu atomic orbits, CuPPy-NH2 NPs also show T1-weighted magnetic resonance imaging.Conclusions: This kind of transition metal-doped polymer gives a competitive approach for designing and fabricating multimodal theranostic nanodevices, which shows the potential in tumor treatment.

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Section: Introductionmentioning

confidence: 99%

“…Thus, Cu(II) and Fe(III) are loaded in PPy-NH 2 (CuPPy-NH 2 ) NPs during the polymerization. Both Cu(II) and Fe(III) can equip PPy-NH 2 NPs with MRI tumor diagnosis 39 , 56 . Besides, Cu(II) can also label PPy-NH 2 NPs and make the NPs traceable in blood and vital organs 57 , 58 .…”

Section: Introductionmentioning

confidence: 99%

Tumor Theranostics of Transition Metal Ions Loaded Polyaminopyrrole Nanoparticles

Liu

Wang

et al. 2018

Nanotheranostics

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“…However, the peroxidase activity slightly decreased after the Cu‐TCPP nanosheets had been cultured with acidic PBS (Figure S9), possibly because of the slight degradation of the Cu‐TCPP under acidic conditions, which also resulted in the release of a trace amount of Cu 2+ ions (0.33 mg g −1 ) relative to its loading content (0.19 g g −1 ) from the nanosheets (Figure G). Furthermore, the presence of GSH (1 m m ) enhanced the released amount of Cu 2+ ions to 0.52 mg g −1 (Figure G) because of the interaction of Cu 2+ with the ‐SH group of GSH …”

Section: Figurementioning

confidence: 99%

Specific Generation of Singlet Oxygen through the Russell Mechanism in Hypoxic Tumors and GSH Depletion by Cu‐TCPP Nanosheets for Cancer Therapy

Wang¹,

Cao²,

Ruan³

et al. 2019

Angewandte Chemie

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The generation of singlet oxygen ( 1 O 2 )d uring photodynamic therapyi sl imited by the precise cooperation of light, photosensitizer,a nd oxygen, and the therapeutic efficiency is restricted by the elevated glutathione (GSH) levels in cancer cells.H erein, we report that an ultrathin twodimensional metal-organic framework of Cu-TCPP nanosheets (TCPP = tetrakis(4-carboxyphenyl)porphyrin) can selectively generate 1 O 2 in at umor microenvironment. This process is based on the peroxidation of the TCPP ligand by acidic H 2 O 2 followed by reduction to peroxylr adicals under the action of the peroxidase-like nanosheets and Cu 2+ ,and their spontaneous recombination reaction by the Russell mechanism. In addition, the nanosheets can also deplete GSH. Consequently,the Cu-TCPP nanosheets can selectively destroy tumor cells with high efficiency,constituting an attractive way to overcome current limitations of photodynamic therapy.

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“…CuPani NSs were prepared according to our previous method. 36 The reaction mixtures were prepared by sequential addition of 0.5 mmol aniline, 1 mmol CuCl 2 and 8 mmol FeCl 3 in 120 mL water. As for the PEG-CuPani and SDS-CuPani NPs, FeCl 3 is replaced by an initiator of 1 mmol (NH 4 ) 2 S 2 O 8 in the solution of PEG and SDS, separately.…”

Section: Preparation Of Cupani Nss and Peg-cupani And Sds-cupani Npsmentioning

confidence: 99%

“…S2 †). According to our previous study, the formula of CuPani NSs is speculated as 36 To evaluate the inuence of electrostatic interactions on tumor uptake, the neutral and negative surface potentials of the CuPani NSs are achieved by adding sodium citrate (Fig. 2d).…”

Section: Cupani Nss and Peg-and Sds-cupani Npsmentioning

confidence: 99%

Electrostatic attraction driven and shuttle-like morphology assisted enhancement for tumor uptake

et al. 2017

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Cu(II) doped polyaniline nanoshuttles for multimodal tumor diagnosis and therapy

Cited by 48 publications

References 53 publications

Tumor Theranostics of Transition Metal Ions Loaded Polyaminopyrrole Nanoparticles

Tumor Theranostics of Transition Metal Ions Loaded Polyaminopyrrole Nanoparticles

Specific Generation of Singlet Oxygen through the Russell Mechanism in Hypoxic Tumors and GSH Depletion by Cu‐TCPP Nanosheets for Cancer Therapy

Electrostatic attraction driven and shuttle-like morphology assisted enhancement for tumor uptake

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