Cu(II) complexes with hydrazone-functionalized phenanthrolines as self-activating metallonucleases

Heinrich, Julian; Stubbe, Jessica; Kulak, Nora

doi:10.1016/j.ica.2017.11.015

Cited by 17 publications

(21 citation statements)

References 37 publications

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“…The IR spectra ύ (cm -1 ) were measured on FT-IR spectrophotometer in potassium bromide (KBr). The 1 H-NMR and 13 C-NMR spectra were measured were measured in DMSO-d6 as solvent at 500 MHz on a JNM-ECA500II NMR spectrometer using tetramethylsilane (TMS) as an internal reference and chemical shifts are expressed as δ ppm. The mass spectra (EI) were recorded on 70 eV with Kratos MS equipment.…”

Section: Methodsmentioning

confidence: 99%

“…1 H NMR (DMSO-d6) δ ppm 0.1-1.06 (m, 10H, H-aliph), 3.79 (s, 3H, OCH3) and 7.035-7.8 (m, 4H, H-Ar) 8.6 (s, 1H, CH=N). 13 C-NMR (DMSO-d6): δ ppm 5.6, 7.24, 9.36, 11.45 and 165.8. MS (EI): (m/z, %), 241 (M + -1, 9.08), 160 (100).…”

Section: -(Dicyclopropylmethylene)-2-(4-methoxybenzylidene)hydrazinementioning

confidence: 99%

“…1 H NMR (DMSO-d6) δ ppm 0.9-1.0 (m, 10H, H-aliph), 1.1(t, 3H, CH3), 2.2(S, 3H, CH3), 1.1(t, 3H, CH3), 2.2(S, 2H, CH2)and 4.0(q, 2H, CH2 ester). 13 Thiosemicarbazide (1 mmol) was added to an equimolar amounts of solution of 3a (1 mmol) in 25 mL of absolute ethanol and few drops of acetic acid. The reaction mixture was heated under reflux for 12 h then the precipitated crude product was filtered off.…”

Section: Ethyl-3-((dicyclopropylmethylene)hydrazono)butanoate (5)mentioning

confidence: 99%

“…11,12 Cu(II) phenanthroline hydrazone complexes are able to cleave DNA and show cytotoxic activity against cancer cells. 13 Aminoguanidine hydrazones (AGH's) have potential important towards developing focused adjuvants for antibiotic drug therapies against bacterial multidrug resistance. 14 These compounds also evaluated for their in vitro α-glucosidase inhibitory activity.…”

Section: Introductionmentioning

confidence: 99%

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Biological Activity of Some Newly Synthesized Hydrazone Derivatives Derived From (Dicyclopropylmethylene)hydrazone

Abdel‐Motaal¹,

Nabil²

2018

ECB

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A series of new hydrazone derivatives were synthesized using dicyclopropyl ketone as starting material. Unexpected reaction of salicylaldehyde with (dicyclopropylmethylene)hydrazine yielded the appropriate bis(salicylaldehyde azine). Treatment of the (dicyclopropylmethylene)hydrazine with the appropriate coupling agents gave the corresponding imides, imidazolones, oxazolones, quinazolinones and triazoles, respectively. The synthesized compounds were characterized using IR, 1 H-NMR, 13 C-NMR and mass spectral data. These newly formed products were tested for their antibacterial and antifungal activities and most of the compounds showed high activity compared with Ciprofloxacin as positive controls. In addition, the compounds were also, examined for their anticancer activities against breast cancer cell line (MCF7) compared with cisplatin as a positive control. The novel synthesized compounds showed satisfactory activity against (MCF7) with mean IC50 values ranging from 21.5 to 100 μM.

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Section: Methodsmentioning

confidence: 99%

Section: -(Dicyclopropylmethylene)-2-(4-methoxybenzylidene)hydrazinementioning

confidence: 99%

Section: Ethyl-3-((dicyclopropylmethylene)hydrazono)butanoate (5)mentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Biological Activity of Some Newly Synthesized Hydrazone Derivatives Derived From (Dicyclopropylmethylene)hydrazone

Abdel‐Motaal¹,

Nabil²

2018

ECB

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“…In the last few decades 1,10‐phenanthroline (phen) has played an important role in coordination chemistry due to its broad field of applications. This ligand has received enormous interest due to its rich functionalization chemistry, its chelating properties towards several metal ions and biological activity of the corresponding metal complexes …”

Section: Introductionmentioning

confidence: 99%

Synthesis of Quinoline/Phenanthroline Impregnated Sugarcane Bagasse for Recovering Uranium(VI) and Thorium(IV) from their Solutions

Bakry

2020

Zeitschrift anorg allge chemie

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This present research aims to synthesize and investigate the adsorption potential of sugarcane bagasse (SCB) impregnated with 8 hydroxy quinolone 8-(HQ) and 1,10 phenethroline (phen) to prepare impregnated sugarcane bagasse (ISCB) for removal U VI and Th IV . The effects of the operating parameters, including pH of the solution, contact time, initial concentration, temperature, dose and interfering ions on the adsorption efficiency were investigated to identify an optimal condition. The characterization of SEM-EDX and FTIR analyses shows that ISCB has a porous structure and carbon-containing func-* A. R. Bakry E-Mail: Bakrynma@yahoo.com [a] Nuclear Materials Authority

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Nuclease-like metalloscissors: Biomimetic candidates for cancer and bacterial and viral infections therapy

Anjomshoa

Amirheidari

2022

Coordination Chemistry Reviews

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Despite the extensive and rapid discovery of modern drugs for treatment of cancer, microbial infections, and viral illnesses; these diseases are still among major global health concerns. To take inspiration from natural nucleases and also the therapeutic potential of metallopeptide antibiotics such as the bleomycin family, artificial metallonucleases with the ability of promoting DNA/RNA cleavage and eventually affecting cellular biological processes can be introduced as a new class of therapeutic candidates. Metal complexes can be considered as one of the main categories of artificial metalloscissors, which can prompt nucleic acid strand scission. Accordingly, biologists, inorganic chemists, and medicinal inorganic chemists worldwide have been designing, synthesizing and evaluating the biological properties of metal complexes as artificial metalloscissors. In this review, we try to highlight the recent studies conducted on the nuclease-like metalloscissors and their potential therapeutic applications. Under the light of the concurrent Covid-19 pandemic, the human need for new therapeutics was highlighted much more than ever before. The nuclease-like metalloscissors with the potential of RNA cleavage of invading viral pathogens hence deserve prime attention.

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Cu(II) complexes with hydrazone-functionalized phenanthrolines as self-activating metallonucleases

Cited by 17 publications

References 37 publications

Biological Activity of Some Newly Synthesized Hydrazone Derivatives Derived From (Dicyclopropylmethylene)hydrazone

Biological Activity of Some Newly Synthesized Hydrazone Derivatives Derived From (Dicyclopropylmethylene)hydrazone

Synthesis of Quinoline/Phenanthroline Impregnated Sugarcane Bagasse for Recovering Uranium(VI) and Thorium(IV) from their Solutions

Nuclease-like metalloscissors: Biomimetic candidates for cancer and bacterial and viral infections therapy

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