Cu(II) complexes of 2-(diphenylmethylene)hydrazinecarboxamide derivatives: Synthesis, characterization and antifungal activity against Fusarium oxysporum f. sp. cubense tropical race 4

Chan, Yi-Chen; Ali, Abdussalam Salhin Mohamed; Salleh, Baharuddin; Rosli, Hafizi; Quah, Ching Kheng

doi:10.1016/j.arabjc.2014.02.014

Cited by 4 publications

(2 citation statements)

References 35 publications

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“…Crude extracts obtained from Streptomyces violaceusniger are also inhibitors of FocTR4 spore germination of [37]. Synthetic Cu(II) complexes with benzophenone derivatives have also shown antifungal activity against FocTR4 [38]. Although these results are promising, more compounds need to be screened to increase the repertoire of innocuous-to-humans and environmentally friendly fungicides.…”

Section: Discussionmentioning

confidence: 99%

The 5´ → 3´ Exoribonuclease 2 as a Potential Target for Developing Fungicides to Control the Panama Disease

Ld¹,

Ma²

2018

J Plant Pathol Microbiol

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An outbreak of Fusarium oxysporum f. sp. cubense Tropical Race 4 is currently threatening the global production of bananas. Due to the clonal nature of commercial banana plants, selecting resistant cultivars does not seem feasible; therefore, alternative approaches to crop protection must be developed. The 5´ → 3´ exoribonuclease XRN2/RAT1 is involved in 5´ → 3´ RNA decay. Fungal studies with XRN2 and conditional mutants have illustrated the crucial role of this enzyme, suggesting XRN2 should be considered as target to searching for novel inhibitors that might be used as fungicides to control Panama disease. Our in silico analysis of Tropical Race 4 XRN2 (FocTR4XRN2) revealed characteristic features of 5´ → 3´ exoribonuclease such as the catalytic domain that recognizes 5´-monophosphorylated RNA and catalyses the processed cleavage of mononucleotides. A delimited cavity showing the potential for substrate uptake appears prone to interacting with small molecules that might inhibit its activity. The catalytic domain in FocTR4XRN2 harbors a CCHC motif, which is conserved in orthologous proteins from filamentous fungi but lacking in yeasts. The residues involved in the interaction with the pyrophosphohydrolase RAI1 are also conserved. Molecular docking reveals the potential interaction of FocTR4XRN2 with the natural inhibitor adenosine 3´, 5´ bisphosphate, and suggests this approach is reliable to screen for novel enzyme inhibitors that could be help in suppressing the progression of causal agents of Panama disease.

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Section: Discussionmentioning

confidence: 99%

The 5´ → 3´ Exoribonuclease 2 as a Potential Target for Developing Fungicides to Control the Panama Disease

Ld¹,

Ma²

2018

J Plant Pathol Microbiol

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“…Its owes us to synthesize new thiosemicarbazone metal complexes and to study their biological activities. Metal complexes of thiosemicarbazones were proven as anti-bacterial 5,6,7 , anti-fungal 8,9 , anti-cancer 10,11 agents. Chandra and Vandana 12 had reported the anti-bacterial and anti-cancer activities of copper and nickel complexes of 2-carboxybenzaldehyde thiosemicarbazone.…”

Section: Introductionmentioning

confidence: 99%

Synthesis, Characterization of Copper Complexes of 9H-Carbazole-3-carbaldehyde-4-phenylthiosemicarbazone, 10-Hexyl-10-H-phenothiazine-3-carbaldehyde-4-phenylthio semicarbazone and 2-Thiophenecarboxaldehyde-4-methyl- thiosemicarbazone and Anti-bacterial Activity Studies of Ligands and Complexes

Jyothi

Farook²,

Madhuri

et al. 2020

Orient. J. Chem

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In Coordination chemistry metal chelating agents has a vital role, among them thiosemicarbazones occupies an important place due to their a range of applications in different fields, such as analytical and biological. In the literature we can find many thiosemicarbazones which has a wide range of applications both in pharmacy and chemical fields. But still there is a scope is there to synthesize new thiosemicarbazone ligands and their metal complexes due to their utility is still there in modern chemistry also. In this present study we synthesized the copper(II) complexes of 9H-Carbazole-3-carbaldehyde-4-phenylthiosemicarbazone, 10-hexyl-10-H-phenothiazine-3-carbaldehyde-4-phenylthiosemicarbazone and 2-thiophenecarboxalde-hyde-4-methylthiosemicarbazone and these complexes are characterized with FT-IR, XRD analysis and thermal stabilities of the both ligands and complexes are compared with thermogravimetric analysis studies. Finally the antibacterial activities of both chelating agents and their metal complexes are tested with two Gram-positive bacterial stains, such as Bacillus subtilis, Staphylococcus aureus and two Gram-negative bacterial stains, Pseudomonas aeruginosa, Escherichia coli.

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Synthesis, spectroscopic characterization and antifungal activity studies of five novel complexes with pyridine carboxamides

et al. 2017

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Cu(II) complexes of 2-(diphenylmethylene)hydrazinecarboxamide derivatives: Synthesis, characterization and antifungal activity against Fusarium oxysporum f. sp. cubense tropical race 4

Cited by 4 publications

References 35 publications

The 5´ → 3´ Exoribonuclease 2 as a Potential Target for Developing Fungicides to Control the Panama Disease

The 5´ → 3´ Exoribonuclease 2 as a Potential Target for Developing Fungicides to Control the Panama Disease

Synthesis, Characterization of Copper Complexes of 9H-Carbazole-3-carbaldehyde-4-phenylthiosemicarbazone, 10-Hexyl-10-H-phenothiazine-3-carbaldehyde-4-phenylthio semicarbazone and 2-Thiophenecarboxaldehyde-4-methyl- thiosemicarbazone and Anti-bacterial Activity Studies of Ligands and Complexes

Synthesis, spectroscopic characterization and antifungal activity studies of five novel complexes with pyridine carboxamides

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