Cu(I)-phosphine complex: An efficient catalyst for synthesis of 3-indole derivatives through one-pot MCR under mild conditions

One-pot sequential multi-component reaction: Synthesis of 3-substituted indoles

“…yl)(phenyl)methyl)malononitrile (4g):7 Light brown solid, (203 mg, 75%); mp = 172-175 o C;1 H NMR (600 MHz, CDCl 3 ): δ 8.31 (s, 1H), 7.46-7.44 (m, 2H), 7.41-7.36 (m, 5H), 7.30 (d, J = 7.4 Hz, 1H), 7.23 (t, J = 7.4 Hz, 1H), 7.07 (t, J = 7.4 Hz, 1H), 4.94 (d, J = 5.2 Hz, 1H), 4.46 (d, J = 5.2 Hz, 1H); 13 C NMR (75 MHz, CDCl 3 + 3 drops of DMSO-d 6 ): δ 137.4, 136.3, 128.7, 128.2, 128.0, 125.7, 122.4, 122.1, 119.4, 118.2, 112.5, 112.4, 111.6, 43.8, 29.3.…”

Synthesis of Medicinally Important Indole Derivatives: A Review

“…Following are the reactions where the synthesis of indole derivatives has been carried out in water: a) A.N. Prasad et al successfully used multi-component reaction for the preparation of 3-substituted indole [75]. With water as medium, indole along with aldehydes and active methylene compound in the presence of catalyst Cu(PPh 3 )Cl (Scheme 17) yielded potentially important indole derivatives.…”

Cu(I)-Catalyzed Three-Component Cyclization for the Construction of Functionalized Thiazoles

“…In the past two decades, there was a vigorous development of transition metal-catalyzed multicomponent reactions (MCRs), which became a highly effective tool in modern organic synthesis . Among these, copper-catalyzed three-component reactions for the rapid construction of diverse and complex heterocyclic molecules by the formation of multiple new bonds in one step receive more and more attention. , Via this strategy, complex molecules can be rapidly built, which can reduce waste compared with multistep reactions. To date, the preparation of functionalized thiazoles from thioamides via three-component reactions catalyzed by transition metal has been rarely documented .…”