Cu-Catalyzed Carbocyclization for General Synthesis of N-Containing Heterocyclics Enabled by BrCF2COOEt as a C1 Source
Xiao-Fang Song,
Li-Jing Zhang,
Xing-Guo Zhang
et al.
Abstract:A practical
and efficient copper-catalyzed carbocyclization of
2-functionalized anilines with ethyl bromodifluoroacetate has been
developed. Ethyl bromodifluoroacetate is employed as the C1 source
via quadruple cleavage in this transformation. This reaction can afford
a variety of N-containing heterocyclics with satisfactory
yields and excellent functional group compatibility.
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